Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease

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Standard

Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease. / Jensen, Camilla Steen; Portelius, Erik; Siersma, Volkert; Høgh, Peter; Wermuth, Lene; Blennow, Kaj; Zetterberg, Henrik; Waldemar, Gunhild; Hasselbalch, Steen Gregers; Simonsen, Anja Hviid.

I: Dementia and Geriatric Cognitive Disorders, Bind 42, Nr. 3-4, 10.2016, s. 146-158.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jensen, CS, Portelius, E, Siersma, V, Høgh, P, Wermuth, L, Blennow, K, Zetterberg, H, Waldemar, G, Hasselbalch, SG & Simonsen, AH 2016, 'Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease', Dementia and Geriatric Cognitive Disorders, bind 42, nr. 3-4, s. 146-158. https://doi.org/10.1159/000449408

APA

Jensen, C. S., Portelius, E., Siersma, V., Høgh, P., Wermuth, L., Blennow, K., Zetterberg, H., Waldemar, G., Hasselbalch, S. G., & Simonsen, A. H. (2016). Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease. Dementia and Geriatric Cognitive Disorders, 42(3-4), 146-158. https://doi.org/10.1159/000449408

Vancouver

Jensen CS, Portelius E, Siersma V, Høgh P, Wermuth L, Blennow K o.a. Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease. Dementia and Geriatric Cognitive Disorders. 2016 okt.;42(3-4):146-158. https://doi.org/10.1159/000449408

Author

Jensen, Camilla Steen ; Portelius, Erik ; Siersma, Volkert ; Høgh, Peter ; Wermuth, Lene ; Blennow, Kaj ; Zetterberg, Henrik ; Waldemar, Gunhild ; Hasselbalch, Steen Gregers ; Simonsen, Anja Hviid. / Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease. I: Dementia and Geriatric Cognitive Disorders. 2016 ; Bind 42, Nr. 3-4. s. 146-158.

Bibtex

@article{d2ceec7daec14943bdce4beef3ea5a2a,
title = "Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease",
abstract = "Background: Physical exercise may have some effect on cognition in patients with Alzheimer disease (AD). However, the underlying biochemical effects are unclear. Animal studies have shown that amyloid beta (Aβ), one of the pathological hallmarks of AD, can be altered with high levels of physical activity. Aim: The objective of this study was to elucidate the effect of 16 weeks of moderate- to high-intensity physical exercise on the biomarkers of AD, with special emphasis on the amyloidogenic pathway. Methods: From a total of 53 patients with AD participating in the Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX) study we analyzed cerebrospinal fluid samples for Aβ species, total tau (t-tau), phosphorylated tau (p-tau) and soluble amyloid precursor protein (sAPP) species. We also assessed the patients for apolipoprotein E ε4 (ApoE ε4) genotype. Results: We found no effect of 16 weeks of physical exercise on the selected biomarkers, and no effect of ApoE ε4 genotype. Conclusion: Our findings suggest that the possible effect of physical exercise on cognition in patients with AD is not due to modulation of Aβ, t-tau, p-tau and sAPP species.",
keywords = "Dementia, Alzheimer disease, Amyloid beta, Amyloid, Physical activity",
author = "Jensen, {Camilla Steen} and Erik Portelius and Volkert Siersma and Peter H{\o}gh and Lene Wermuth and Kaj Blennow and Henrik Zetterberg and Gunhild Waldemar and Hasselbalch, {Steen Gregers} and Simonsen, {Anja Hviid}",
year = "2016",
month = oct,
doi = "10.1159/000449408",
language = "English",
volume = "42",
pages = "146--158",
journal = "Dementia and Geriatric Cognitive Disorders",
issn = "1420-8008",
publisher = "S Karger AG",
number = "3-4",

}

RIS

TY - JOUR

T1 - Cerebrospinal Fluid Amyloid Beta and Tau Concentrations Are Not Modulated by 16 Weeks of Moderate- to High-Intensity Physical Exercise in Patients with Alzheimer Disease

AU - Jensen, Camilla Steen

AU - Portelius, Erik

AU - Siersma, Volkert

AU - Høgh, Peter

AU - Wermuth, Lene

AU - Blennow, Kaj

AU - Zetterberg, Henrik

AU - Waldemar, Gunhild

AU - Hasselbalch, Steen Gregers

AU - Simonsen, Anja Hviid

PY - 2016/10

Y1 - 2016/10

N2 - Background: Physical exercise may have some effect on cognition in patients with Alzheimer disease (AD). However, the underlying biochemical effects are unclear. Animal studies have shown that amyloid beta (Aβ), one of the pathological hallmarks of AD, can be altered with high levels of physical activity. Aim: The objective of this study was to elucidate the effect of 16 weeks of moderate- to high-intensity physical exercise on the biomarkers of AD, with special emphasis on the amyloidogenic pathway. Methods: From a total of 53 patients with AD participating in the Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX) study we analyzed cerebrospinal fluid samples for Aβ species, total tau (t-tau), phosphorylated tau (p-tau) and soluble amyloid precursor protein (sAPP) species. We also assessed the patients for apolipoprotein E ε4 (ApoE ε4) genotype. Results: We found no effect of 16 weeks of physical exercise on the selected biomarkers, and no effect of ApoE ε4 genotype. Conclusion: Our findings suggest that the possible effect of physical exercise on cognition in patients with AD is not due to modulation of Aβ, t-tau, p-tau and sAPP species.

AB - Background: Physical exercise may have some effect on cognition in patients with Alzheimer disease (AD). However, the underlying biochemical effects are unclear. Animal studies have shown that amyloid beta (Aβ), one of the pathological hallmarks of AD, can be altered with high levels of physical activity. Aim: The objective of this study was to elucidate the effect of 16 weeks of moderate- to high-intensity physical exercise on the biomarkers of AD, with special emphasis on the amyloidogenic pathway. Methods: From a total of 53 patients with AD participating in the Preserving Cognition, Quality of Life, Physical Health and Functional Ability in Alzheimer's Disease: The Effect of Physical Exercise (ADEX) study we analyzed cerebrospinal fluid samples for Aβ species, total tau (t-tau), phosphorylated tau (p-tau) and soluble amyloid precursor protein (sAPP) species. We also assessed the patients for apolipoprotein E ε4 (ApoE ε4) genotype. Results: We found no effect of 16 weeks of physical exercise on the selected biomarkers, and no effect of ApoE ε4 genotype. Conclusion: Our findings suggest that the possible effect of physical exercise on cognition in patients with AD is not due to modulation of Aβ, t-tau, p-tau and sAPP species.

KW - Dementia

KW - Alzheimer disease

KW - Amyloid beta

KW - Amyloid

KW - Physical activity

U2 - 10.1159/000449408

DO - 10.1159/000449408

M3 - Journal article

C2 - 27643858

VL - 42

SP - 146

EP - 158

JO - Dementia and Geriatric Cognitive Disorders

JF - Dementia and Geriatric Cognitive Disorders

SN - 1420-8008

IS - 3-4

ER -

ID: 170082460