Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis

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Standard

Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis. / El Mahdaoui, Sahla; Husted, Signe Refstrup; Hansen, Malene Bredahl; Cobanovic, Stefan; Mahler, Mie Reith; Buhelt, Sophie; von Essen, Marina Rode; Sellebjerg, Finn; Christensen, Jeppe Romme.

I: Journal of Neuroimmunology, Bind 381, 578128, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

El Mahdaoui, S, Husted, SR, Hansen, MB, Cobanovic, S, Mahler, MR, Buhelt, S, von Essen, MR, Sellebjerg, F & Christensen, JR 2023, 'Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis', Journal of Neuroimmunology, bind 381, 578128. https://doi.org/10.1016/j.jneuroim.2023.578128

APA

El Mahdaoui, S., Husted, S. R., Hansen, M. B., Cobanovic, S., Mahler, M. R., Buhelt, S., von Essen, M. R., Sellebjerg, F., & Christensen, J. R. (2023). Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis. Journal of Neuroimmunology, 381, [578128]. https://doi.org/10.1016/j.jneuroim.2023.578128

Vancouver

El Mahdaoui S, Husted SR, Hansen MB, Cobanovic S, Mahler MR, Buhelt S o.a. Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis. Journal of Neuroimmunology. 2023;381. 578128. https://doi.org/10.1016/j.jneuroim.2023.578128

Author

El Mahdaoui, Sahla ; Husted, Signe Refstrup ; Hansen, Malene Bredahl ; Cobanovic, Stefan ; Mahler, Mie Reith ; Buhelt, Sophie ; von Essen, Marina Rode ; Sellebjerg, Finn ; Christensen, Jeppe Romme. / Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis. I: Journal of Neuroimmunology. 2023 ; Bind 381.

Bibtex

@article{3f34395e6f144ef381eb0f1e98791781,
title = "Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis",
abstract = "Cerebrospinal fluid (CSF) soluble CD27 (sCD27) is a sensitive biomarker of intrathecal inflammation. Although generally considered a biomarker of T cell activation, CSF sCD27 has been shown to correlate with biomarkers of B cell activity in multiple sclerosis. We analyzed CSF from 40 patients with relapsing-remitting multiple sclerosis (RRMS) and nine symptomatic controls using flow cytometry and multiplex electrochemiluminescence immunoassays. CSF sCD27 levels were increased in RRMS and correlated with IgG index, soluble B cell maturation antigen, cell count, B cell frequency and CD8+ T cell frequency. We provide new data indicating that CSF sCD27 is associated with CD8+ T cells and B cells in RRMS.",
keywords = "CSF, Intrathecal inflammation, Lymphocytes, RRMS, sBCMA, sCD27",
author = "{El Mahdaoui}, Sahla and Husted, {Signe Refstrup} and Hansen, {Malene Bredahl} and Stefan Cobanovic and Mahler, {Mie Reith} and Sophie Buhelt and {von Essen}, {Marina Rode} and Finn Sellebjerg and Christensen, {Jeppe Romme}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.jneuroim.2023.578128",
language = "English",
volume = "381",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Cerebrospinal fluid soluble CD27 is associated with CD8+ T cells, B cells and biomarkers of B cell activity in relapsing-remitting multiple sclerosis

AU - El Mahdaoui, Sahla

AU - Husted, Signe Refstrup

AU - Hansen, Malene Bredahl

AU - Cobanovic, Stefan

AU - Mahler, Mie Reith

AU - Buhelt, Sophie

AU - von Essen, Marina Rode

AU - Sellebjerg, Finn

AU - Christensen, Jeppe Romme

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - Cerebrospinal fluid (CSF) soluble CD27 (sCD27) is a sensitive biomarker of intrathecal inflammation. Although generally considered a biomarker of T cell activation, CSF sCD27 has been shown to correlate with biomarkers of B cell activity in multiple sclerosis. We analyzed CSF from 40 patients with relapsing-remitting multiple sclerosis (RRMS) and nine symptomatic controls using flow cytometry and multiplex electrochemiluminescence immunoassays. CSF sCD27 levels were increased in RRMS and correlated with IgG index, soluble B cell maturation antigen, cell count, B cell frequency and CD8+ T cell frequency. We provide new data indicating that CSF sCD27 is associated with CD8+ T cells and B cells in RRMS.

AB - Cerebrospinal fluid (CSF) soluble CD27 (sCD27) is a sensitive biomarker of intrathecal inflammation. Although generally considered a biomarker of T cell activation, CSF sCD27 has been shown to correlate with biomarkers of B cell activity in multiple sclerosis. We analyzed CSF from 40 patients with relapsing-remitting multiple sclerosis (RRMS) and nine symptomatic controls using flow cytometry and multiplex electrochemiluminescence immunoassays. CSF sCD27 levels were increased in RRMS and correlated with IgG index, soluble B cell maturation antigen, cell count, B cell frequency and CD8+ T cell frequency. We provide new data indicating that CSF sCD27 is associated with CD8+ T cells and B cells in RRMS.

KW - CSF

KW - Intrathecal inflammation

KW - Lymphocytes

KW - RRMS

KW - sBCMA

KW - sCD27

U2 - 10.1016/j.jneuroim.2023.578128

DO - 10.1016/j.jneuroim.2023.578128

M3 - Journal article

C2 - 37321014

AN - SCOPUS:85161643611

VL - 381

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

M1 - 578128

ER -

ID: 362742796