Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

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Standard

Characterization of naïve, memory and effector T cells in progressive multiple sclerosis. / Nielsen, Birgitte Romme; Ratzer, Rikke; Börnsen, Lars; von Essen, Marina Rode; Christensen, Jeppe Romme; Sellebjerg, Finn.

I: Journal of Neuroimmunology, Bind 310, 2017, s. 17-25.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nielsen, BR, Ratzer, R, Börnsen, L, von Essen, MR, Christensen, JR & Sellebjerg, F 2017, 'Characterization of naïve, memory and effector T cells in progressive multiple sclerosis', Journal of Neuroimmunology, bind 310, s. 17-25. https://doi.org/10.1016/j.jneuroim.2017.06.001

APA

Nielsen, B. R., Ratzer, R., Börnsen, L., von Essen, M. R., Christensen, J. R., & Sellebjerg, F. (2017). Characterization of naïve, memory and effector T cells in progressive multiple sclerosis. Journal of Neuroimmunology, 310, 17-25. https://doi.org/10.1016/j.jneuroim.2017.06.001

Vancouver

Nielsen BR, Ratzer R, Börnsen L, von Essen MR, Christensen JR, Sellebjerg F. Characterization of naïve, memory and effector T cells in progressive multiple sclerosis. Journal of Neuroimmunology. 2017;310:17-25. https://doi.org/10.1016/j.jneuroim.2017.06.001

Author

Nielsen, Birgitte Romme ; Ratzer, Rikke ; Börnsen, Lars ; von Essen, Marina Rode ; Christensen, Jeppe Romme ; Sellebjerg, Finn. / Characterization of naïve, memory and effector T cells in progressive multiple sclerosis. I: Journal of Neuroimmunology. 2017 ; Bind 310. s. 17-25.

Bibtex

@article{38677f4d9bb24391876a9f71dcaa2bfd,
title = "Characterization of na{\"i}ve, memory and effector T cells in progressive multiple sclerosis",
abstract = "We characterized na{\"i}ve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.",
keywords = "CD26, CD49, Memory, Natalizumab, Progressive MS, T cells",
author = "Nielsen, {Birgitte Romme} and Rikke Ratzer and Lars B{\"o}rnsen and {von Essen}, {Marina Rode} and Christensen, {Jeppe Romme} and Finn Sellebjerg",
year = "2017",
doi = "10.1016/j.jneuroim.2017.06.001",
language = "English",
volume = "310",
pages = "17--25",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Characterization of naïve, memory and effector T cells in progressive multiple sclerosis

AU - Nielsen, Birgitte Romme

AU - Ratzer, Rikke

AU - Börnsen, Lars

AU - von Essen, Marina Rode

AU - Christensen, Jeppe Romme

AU - Sellebjerg, Finn

PY - 2017

Y1 - 2017

N2 - We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.

AB - We characterized naïve, central memory (CM), effector memory (EM) and terminally differentiated effector memory (TEMRA) CD4+ and CD8+ T cells and their expression of CD49d and CD26 in peripheral blood in patients with multiple sclerosis (MS) and healthy controls. CD26+ CD28+ CD4+ TEMRA T cells were increased in all subtypes of MS, and CD26+ CD28+ CD8+ TEMRA T cells were increased in relapsing-remitting and secondary progressive MS. Conversely, in progressive MS, CD49d+ CM T cells were decreased and natalizumab increased the circulating number of all six subsets but reduced the frequency of most subsets expressing CD49d and CD26.

KW - CD26

KW - CD49

KW - Memory

KW - Natalizumab

KW - Progressive MS

KW - T cells

U2 - 10.1016/j.jneuroim.2017.06.001

DO - 10.1016/j.jneuroim.2017.06.001

M3 - Journal article

C2 - 28778440

AN - SCOPUS:85020812830

VL - 310

SP - 17

EP - 25

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -

ID: 196908358