Chemokines and matrix metalloproteinase-9 in leukocyte recruitment to the central nervous system
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Chemokines and matrix metalloproteinase-9 in leukocyte recruitment to the central nervous system. / Sellebjerg, F.; Sørensen, T. L.
I: Brain Research Bulletin, Bind 61, Nr. 3, 15.08.2003, s. 347-355.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Chemokines and matrix metalloproteinase-9 in leukocyte recruitment to the central nervous system
AU - Sellebjerg, F.
AU - Sørensen, T. L.
PY - 2003/8/15
Y1 - 2003/8/15
N2 - Chemokines and matrix metalloproteinases (MMPs) play key roles in leukocyte migration across the blood-brain barrier (BBB) in infectious and inflammatory diseases, including multiple sclerosis (MS). In MS some chemokine receptors are expressed by an increased percentage of T cells in blood, the CSF concentration of chemokine ligands for these receptors is increased, and there is accumulation of T cells expressing relevant chemokine receptors in CSF and in the CNS parenchyma. Chemokine receptor expression patterns appear to reflect disease activity and disease stage in MS. MMPs are constitutively expressed or induced by proinflammatory cytokines and chemokines in leukocytes and CNS-resident cells. Several MMPs are expressed in MS plaques, and the CSF concentration of MMP-9 is increased in MS. The CSF concentration of MMP-9 may reflect disease activity in MS, and the CSF concentration of MMP-9 is higher in patients carrying the MS-associated HLA type DRB1*1501. We review how chemokines and MMP-9 may be involved in the pathogenesis of MS by controlling leukocyte migration between different functional compartments. Measuring expression of these molecules may find use as surrogate markers of disease activity in MS, and interfering with their function holds promise as a novel therapeutic strategy in MS.
AB - Chemokines and matrix metalloproteinases (MMPs) play key roles in leukocyte migration across the blood-brain barrier (BBB) in infectious and inflammatory diseases, including multiple sclerosis (MS). In MS some chemokine receptors are expressed by an increased percentage of T cells in blood, the CSF concentration of chemokine ligands for these receptors is increased, and there is accumulation of T cells expressing relevant chemokine receptors in CSF and in the CNS parenchyma. Chemokine receptor expression patterns appear to reflect disease activity and disease stage in MS. MMPs are constitutively expressed or induced by proinflammatory cytokines and chemokines in leukocytes and CNS-resident cells. Several MMPs are expressed in MS plaques, and the CSF concentration of MMP-9 is increased in MS. The CSF concentration of MMP-9 may reflect disease activity in MS, and the CSF concentration of MMP-9 is higher in patients carrying the MS-associated HLA type DRB1*1501. We review how chemokines and MMP-9 may be involved in the pathogenesis of MS by controlling leukocyte migration between different functional compartments. Measuring expression of these molecules may find use as surrogate markers of disease activity in MS, and interfering with their function holds promise as a novel therapeutic strategy in MS.
KW - Cerebrospinal fluid
KW - Inflammatory demyelination
KW - Macrophages
KW - Multiple sclerosis
KW - T cells
UR - http://www.scopus.com/inward/record.url?scp=0042591142&partnerID=8YFLogxK
U2 - 10.1016/S0361-9230(03)00097-2
DO - 10.1016/S0361-9230(03)00097-2
M3 - Journal article
C2 - 12909304
AN - SCOPUS:0042591142
VL - 61
SP - 347
EP - 355
JO - Brain Research Bulletin
JF - Brain Research Bulletin
SN - 0361-9230
IS - 3
ER -
ID: 229733983