Detection of subclinical epileptiform discharges in Alzheimer's disease using long-term outpatient EEG monitoring
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Detection of subclinical epileptiform discharges in Alzheimer's disease using long-term outpatient EEG monitoring. / Musaeus, Christian Sandøe; Frederiksen, Kristian Steen; Andersen, Birgitte Bo; Høgh, Peter; Kidmose, Preben; Fabricius, Martin; Hribljan, Melita Cacic; Hemmsen, Martin Christian; Rank, Mike Lind; Waldemar, Gunhild; Kjær, Troels Wesenberg.
I: Neurobiology of Disease, Bind 183, 106149, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Detection of subclinical epileptiform discharges in Alzheimer's disease using long-term outpatient EEG monitoring
AU - Musaeus, Christian Sandøe
AU - Frederiksen, Kristian Steen
AU - Andersen, Birgitte Bo
AU - Høgh, Peter
AU - Kidmose, Preben
AU - Fabricius, Martin
AU - Hribljan, Melita Cacic
AU - Hemmsen, Martin Christian
AU - Rank, Mike Lind
AU - Waldemar, Gunhild
AU - Kjær, Troels Wesenberg
N1 - Publisher Copyright: © 2023
PY - 2023
Y1 - 2023
N2 - Background: In patients with Alzheimer's disease (AD) without clinical seizures, up to half have epileptiform discharges on long-term in-patient electroencephalography (EEG) recordings. Long-term in-patient monitoring is obtrusive, and expensive as compared to outpatient monitoring. No studies have so far investigated if long-term outpatient EEG monitoring is able to identify epileptiform discharges in AD. Our aim is to investigate if epileptiform discharges as measured with ear-EEG are more common in patients with AD compared to healthy elderly controls (HC). Methods: In this longitudinal observational study, 24 patients with mild to moderate AD and 15 age-matched HC were included in the analysis. Patients with AD underwent up to three ear-EEG recordings, each lasting up to two days, within 6 months. Results: The first recording was defined as the baseline recording. At baseline, epileptiform discharges were detected in 75.0% of patients with AD and in 46.7% of HC (p-value = 0.073). The spike frequency (spikes or sharp waves/24 h) was significantly higher in patients with AD as compared to HC with a risk ratio of 2.90 (CI: 1.77–5.01, p < 0.001). Most patients with AD (91.7%) showed epileptiform discharges when combining all ear-EEG recordings. Conclusions: Long-term ear-EEG monitoring detects epileptiform discharges in most patients with AD with a three-fold increased spike frequency compared to HC, which most likely originates from the temporal lobes. Since most patients showed epileptiform discharges with multiple recordings, elevated spike frequency should be considered a marker of hyperexcitability in AD.
AB - Background: In patients with Alzheimer's disease (AD) without clinical seizures, up to half have epileptiform discharges on long-term in-patient electroencephalography (EEG) recordings. Long-term in-patient monitoring is obtrusive, and expensive as compared to outpatient monitoring. No studies have so far investigated if long-term outpatient EEG monitoring is able to identify epileptiform discharges in AD. Our aim is to investigate if epileptiform discharges as measured with ear-EEG are more common in patients with AD compared to healthy elderly controls (HC). Methods: In this longitudinal observational study, 24 patients with mild to moderate AD and 15 age-matched HC were included in the analysis. Patients with AD underwent up to three ear-EEG recordings, each lasting up to two days, within 6 months. Results: The first recording was defined as the baseline recording. At baseline, epileptiform discharges were detected in 75.0% of patients with AD and in 46.7% of HC (p-value = 0.073). The spike frequency (spikes or sharp waves/24 h) was significantly higher in patients with AD as compared to HC with a risk ratio of 2.90 (CI: 1.77–5.01, p < 0.001). Most patients with AD (91.7%) showed epileptiform discharges when combining all ear-EEG recordings. Conclusions: Long-term ear-EEG monitoring detects epileptiform discharges in most patients with AD with a three-fold increased spike frequency compared to HC, which most likely originates from the temporal lobes. Since most patients showed epileptiform discharges with multiple recordings, elevated spike frequency should be considered a marker of hyperexcitability in AD.
KW - Alzheimer's disease
KW - Device
KW - Ear-EEG
KW - EEG
KW - Long-term EEG
KW - Subclinical epileptiform discharges
KW - Wearable
U2 - 10.1016/j.nbd.2023.106149
DO - 10.1016/j.nbd.2023.106149
M3 - Journal article
C2 - 37196736
AN - SCOPUS:85160360807
VL - 183
JO - Neurobiology of Disease
JF - Neurobiology of Disease
SN - 0969-9961
M1 - 106149
ER -
ID: 366988015