Differential effects of migraine drugs on cerebral blood flow autoregulation

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Standard

Differential effects of migraine drugs on cerebral blood flow autoregulation. / Vraamark, T; Waldemar, G; Paulson, O B.

I: Cephalalgia : an international journal of headache, Bind 18, Nr. 6, 10.09.1998, s. 306-12.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Vraamark, T, Waldemar, G & Paulson, OB 1998, 'Differential effects of migraine drugs on cerebral blood flow autoregulation', Cephalalgia : an international journal of headache, bind 18, nr. 6, s. 306-12. https://doi.org/10.1046/j.1468-2982.1998.1806306.x

APA

Vraamark, T., Waldemar, G., & Paulson, O. B. (1998). Differential effects of migraine drugs on cerebral blood flow autoregulation. Cephalalgia : an international journal of headache, 18(6), 306-12. https://doi.org/10.1046/j.1468-2982.1998.1806306.x

Vancouver

Vraamark T, Waldemar G, Paulson OB. Differential effects of migraine drugs on cerebral blood flow autoregulation. Cephalalgia : an international journal of headache. 1998 sep. 10;18(6):306-12. https://doi.org/10.1046/j.1468-2982.1998.1806306.x

Author

Vraamark, T ; Waldemar, G ; Paulson, O B. / Differential effects of migraine drugs on cerebral blood flow autoregulation. I: Cephalalgia : an international journal of headache. 1998 ; Bind 18, Nr. 6. s. 306-12.

Bibtex

@article{55235c53c256468796416d5470787bef,
title = "Differential effects of migraine drugs on cerebral blood flow autoregulation",
abstract = "The effect of the migraine drugs ergotamine and sumatriptan on the cerebral blood flow (CBF) autoregulation was studied in halothane/nitrous oxide-anesthetized normotensive Wistar Kyoto rats. Ergotamine, an ergot alkaloid affecting 5HT, norepinephrine, and dopamine receptors, was administered intravenously as a single dose of 25 microg/kg. Sumatriptan, a selective 5HT1-like receptor agonist, was administered by intravenous infusion of 300 microg/kg/h. CBF was measured with the intracarotid 133Xe-injection method. The blood pressure limits of CBF autoregulation were determined by computerized least sum of square analysis. CBF autoregulation was preserved after both ergotamine and sumatriptan. Ergotamine shifted the lower blood pressure limit of CBF autoregulation towards higher blood pressures from 60 +/- 3 mmHg to 82 +/- 4 mmHg (p<0.01), but did not significantly affect the upper blood pressure limit of CBF autoregulation. Sumatriptan had no significant effects on the blood pressure limits of CBF autoregulation.",
keywords = "Animals, Cerebrovascular Circulation/drug effects, Ergotamine/pharmacology, Homeostasis/drug effects, Male, Rats, Rats, Inbred WKY, Serotonin Receptor Agonists/pharmacology, Sumatriptan/pharmacology, Vasoconstrictor Agents/pharmacology",
author = "T Vraamark and G Waldemar and Paulson, {O B}",
year = "1998",
month = sep,
day = "10",
doi = "10.1046/j.1468-2982.1998.1806306.x",
language = "English",
volume = "18",
pages = "306--12",
journal = "Cephalalgia",
issn = "0800-1952",
publisher = "SAGE Publications",
number = "6",

}

RIS

TY - JOUR

T1 - Differential effects of migraine drugs on cerebral blood flow autoregulation

AU - Vraamark, T

AU - Waldemar, G

AU - Paulson, O B

PY - 1998/9/10

Y1 - 1998/9/10

N2 - The effect of the migraine drugs ergotamine and sumatriptan on the cerebral blood flow (CBF) autoregulation was studied in halothane/nitrous oxide-anesthetized normotensive Wistar Kyoto rats. Ergotamine, an ergot alkaloid affecting 5HT, norepinephrine, and dopamine receptors, was administered intravenously as a single dose of 25 microg/kg. Sumatriptan, a selective 5HT1-like receptor agonist, was administered by intravenous infusion of 300 microg/kg/h. CBF was measured with the intracarotid 133Xe-injection method. The blood pressure limits of CBF autoregulation were determined by computerized least sum of square analysis. CBF autoregulation was preserved after both ergotamine and sumatriptan. Ergotamine shifted the lower blood pressure limit of CBF autoregulation towards higher blood pressures from 60 +/- 3 mmHg to 82 +/- 4 mmHg (p<0.01), but did not significantly affect the upper blood pressure limit of CBF autoregulation. Sumatriptan had no significant effects on the blood pressure limits of CBF autoregulation.

AB - The effect of the migraine drugs ergotamine and sumatriptan on the cerebral blood flow (CBF) autoregulation was studied in halothane/nitrous oxide-anesthetized normotensive Wistar Kyoto rats. Ergotamine, an ergot alkaloid affecting 5HT, norepinephrine, and dopamine receptors, was administered intravenously as a single dose of 25 microg/kg. Sumatriptan, a selective 5HT1-like receptor agonist, was administered by intravenous infusion of 300 microg/kg/h. CBF was measured with the intracarotid 133Xe-injection method. The blood pressure limits of CBF autoregulation were determined by computerized least sum of square analysis. CBF autoregulation was preserved after both ergotamine and sumatriptan. Ergotamine shifted the lower blood pressure limit of CBF autoregulation towards higher blood pressures from 60 +/- 3 mmHg to 82 +/- 4 mmHg (p<0.01), but did not significantly affect the upper blood pressure limit of CBF autoregulation. Sumatriptan had no significant effects on the blood pressure limits of CBF autoregulation.

KW - Animals

KW - Cerebrovascular Circulation/drug effects

KW - Ergotamine/pharmacology

KW - Homeostasis/drug effects

KW - Male

KW - Rats

KW - Rats, Inbred WKY

KW - Serotonin Receptor Agonists/pharmacology

KW - Sumatriptan/pharmacology

KW - Vasoconstrictor Agents/pharmacology

U2 - 10.1046/j.1468-2982.1998.1806306.x

DO - 10.1046/j.1468-2982.1998.1806306.x

M3 - Journal article

C2 - 9731933

VL - 18

SP - 306

EP - 312

JO - Cephalalgia

JF - Cephalalgia

SN - 0800-1952

IS - 6

ER -

ID: 274964699