Effect of ketanserin on cerebral blood flow autoregulation in healthy volunteers

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Standard

Effect of ketanserin on cerebral blood flow autoregulation in healthy volunteers. / Schmidt, J F; Olsen, K S; Waldemar, G; Jørgensen, B C; Paulson, O B.

I: Acta Neurochirurgica, Bind 111, Nr. 3-4, 1991, s. 138-42.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Schmidt, JF, Olsen, KS, Waldemar, G, Jørgensen, BC & Paulson, OB 1991, 'Effect of ketanserin on cerebral blood flow autoregulation in healthy volunteers', Acta Neurochirurgica, bind 111, nr. 3-4, s. 138-42. https://doi.org/10.1007/BF01400503

APA

Schmidt, J. F., Olsen, K. S., Waldemar, G., Jørgensen, B. C., & Paulson, O. B. (1991). Effect of ketanserin on cerebral blood flow autoregulation in healthy volunteers. Acta Neurochirurgica, 111(3-4), 138-42. https://doi.org/10.1007/BF01400503

Vancouver

Schmidt JF, Olsen KS, Waldemar G, Jørgensen BC, Paulson OB. Effect of ketanserin on cerebral blood flow autoregulation in healthy volunteers. Acta Neurochirurgica. 1991;111(3-4):138-42. https://doi.org/10.1007/BF01400503

Author

Schmidt, J F ; Olsen, K S ; Waldemar, G ; Jørgensen, B C ; Paulson, O B. / Effect of ketanserin on cerebral blood flow autoregulation in healthy volunteers. I: Acta Neurochirurgica. 1991 ; Bind 111, Nr. 3-4. s. 138-42.

Bibtex

@article{2d27b6ebb07a4237b267a7b927dfcb2e,
title = "Effect of ketanserin on cerebral blood flow autoregulation in healthy volunteers",
abstract = "The effect of a clinically relevant dose of ketanserin (10 mg as a bolus followed by an infusion of 6 mg/h) on cerebral blood flow (CBF) and CBF autoregulation was examined in 12 healthy volunteers. Changes in CBF were estimated by the cerebral arteriovenous-oxygen saturation difference method, while mean arterial blood pressure (MABP) was increased by norepinephrine and decreased by ganglionic blockade (trimethaphan camphosulphonate) combined with lower body negative pressure one hour after the infusion of ketanserin. During ketanserin infusion, MABP fell insignificantly by 2.5 mmHg (6 to -2), while CBF rose insignificantly by 5 ml/100 g/min. Autoregulation was preserved in all volunteers. CO2-correction factors from 0 to 4.6% CBF/0.1 kPa were used. The lower limit of CBF autoregulation was 82 mmHg (80-86) with an SE of 3 mmHg (1-5) similar to a previous control group of healthy volunteers. Aside from a major decrease in MABP in one subject, no adverse side effects were observed. The present study shows that CBF autoregulation is maintained during ketanserin infusion.",
keywords = "Blood Flow Velocity/drug effects, Blood Pressure/drug effects, Brain/blood supply, Carbon Dioxide/blood, Female, Homeostasis/drug effects, Humans, Infusions, Intravenous, Ketanserin/pharmacology, Male, Middle Aged, Oxygen/blood, Regional Blood Flow/drug effects, Tomography, Emission-Computed, Single-Photon",
author = "Schmidt, {J F} and Olsen, {K S} and G Waldemar and J{\o}rgensen, {B C} and Paulson, {O B}",
year = "1991",
doi = "10.1007/BF01400503",
language = "English",
volume = "111",
pages = "138--42",
journal = "Acta Neurochirurgica",
issn = "0001-6268",
publisher = "Springer Wien",
number = "3-4",

}

RIS

TY - JOUR

T1 - Effect of ketanserin on cerebral blood flow autoregulation in healthy volunteers

AU - Schmidt, J F

AU - Olsen, K S

AU - Waldemar, G

AU - Jørgensen, B C

AU - Paulson, O B

PY - 1991

Y1 - 1991

N2 - The effect of a clinically relevant dose of ketanserin (10 mg as a bolus followed by an infusion of 6 mg/h) on cerebral blood flow (CBF) and CBF autoregulation was examined in 12 healthy volunteers. Changes in CBF were estimated by the cerebral arteriovenous-oxygen saturation difference method, while mean arterial blood pressure (MABP) was increased by norepinephrine and decreased by ganglionic blockade (trimethaphan camphosulphonate) combined with lower body negative pressure one hour after the infusion of ketanserin. During ketanserin infusion, MABP fell insignificantly by 2.5 mmHg (6 to -2), while CBF rose insignificantly by 5 ml/100 g/min. Autoregulation was preserved in all volunteers. CO2-correction factors from 0 to 4.6% CBF/0.1 kPa were used. The lower limit of CBF autoregulation was 82 mmHg (80-86) with an SE of 3 mmHg (1-5) similar to a previous control group of healthy volunteers. Aside from a major decrease in MABP in one subject, no adverse side effects were observed. The present study shows that CBF autoregulation is maintained during ketanserin infusion.

AB - The effect of a clinically relevant dose of ketanserin (10 mg as a bolus followed by an infusion of 6 mg/h) on cerebral blood flow (CBF) and CBF autoregulation was examined in 12 healthy volunteers. Changes in CBF were estimated by the cerebral arteriovenous-oxygen saturation difference method, while mean arterial blood pressure (MABP) was increased by norepinephrine and decreased by ganglionic blockade (trimethaphan camphosulphonate) combined with lower body negative pressure one hour after the infusion of ketanserin. During ketanserin infusion, MABP fell insignificantly by 2.5 mmHg (6 to -2), while CBF rose insignificantly by 5 ml/100 g/min. Autoregulation was preserved in all volunteers. CO2-correction factors from 0 to 4.6% CBF/0.1 kPa were used. The lower limit of CBF autoregulation was 82 mmHg (80-86) with an SE of 3 mmHg (1-5) similar to a previous control group of healthy volunteers. Aside from a major decrease in MABP in one subject, no adverse side effects were observed. The present study shows that CBF autoregulation is maintained during ketanserin infusion.

KW - Blood Flow Velocity/drug effects

KW - Blood Pressure/drug effects

KW - Brain/blood supply

KW - Carbon Dioxide/blood

KW - Female

KW - Homeostasis/drug effects

KW - Humans

KW - Infusions, Intravenous

KW - Ketanserin/pharmacology

KW - Male

KW - Middle Aged

KW - Oxygen/blood

KW - Regional Blood Flow/drug effects

KW - Tomography, Emission-Computed, Single-Photon

U2 - 10.1007/BF01400503

DO - 10.1007/BF01400503

M3 - Journal article

C2 - 1950688

VL - 111

SP - 138

EP - 142

JO - Acta Neurochirurgica

JF - Acta Neurochirurgica

SN - 0001-6268

IS - 3-4

ER -

ID: 275017076