Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene

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Standard

Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene. / Nimsanor, Natakarn; Poulsen, Ulla; Rasmussen, Mikkel A.; Clausen, Christian; Mau-Holzmann, Ulrike A; Nielsen, Jørgen E.; Nielsen, Troels T.; Hyttel, Poul; Holst, Bjørn; Schmid, Benjamin.

I: Stem Cell Research, Bind 17, Nr. 3, 11.2016, s. 576-579.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nimsanor, N, Poulsen, U, Rasmussen, MA, Clausen, C, Mau-Holzmann, UA, Nielsen, JE, Nielsen, TT, Hyttel, P, Holst, B & Schmid, B 2016, 'Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene', Stem Cell Research, bind 17, nr. 3, s. 576-579. https://doi.org/10.1016/j.scr.2016.09.020

APA

Nimsanor, N., Poulsen, U., Rasmussen, M. A., Clausen, C., Mau-Holzmann, U. A., Nielsen, J. E., Nielsen, T. T., Hyttel, P., Holst, B., & Schmid, B. (2016). Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Research, 17(3), 576-579. https://doi.org/10.1016/j.scr.2016.09.020

Vancouver

Nimsanor N, Poulsen U, Rasmussen MA, Clausen C, Mau-Holzmann UA, Nielsen JE o.a. Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene. Stem Cell Research. 2016 nov.;17(3):576-579. https://doi.org/10.1016/j.scr.2016.09.020

Author

Nimsanor, Natakarn ; Poulsen, Ulla ; Rasmussen, Mikkel A. ; Clausen, Christian ; Mau-Holzmann, Ulrike A ; Nielsen, Jørgen E. ; Nielsen, Troels T. ; Hyttel, Poul ; Holst, Bjørn ; Schmid, Benjamin. / Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene. I: Stem Cell Research. 2016 ; Bind 17, Nr. 3. s. 576-579.

Bibtex

@article{93f16eba90354926bd5973ae8760c7a6,
title = "Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene",
abstract = "Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the MAPT (microtubule-associated protein tau) gene can cause FTDP-17, but the underlying pathomechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the required cell type. Furthermore, gene-editing approaches allow generating isogenic gene-corrected controls that can be used as a very specific control. Here, we report the generation of genetically corrected iPSCs from a 59-year-old female FTD-17 patient carrying an R406W mutation in the MAPT-gene.",
author = "Natakarn Nimsanor and Ulla Poulsen and Rasmussen, {Mikkel A.} and Christian Clausen and Mau-Holzmann, {Ulrike A} and Nielsen, {J{\o}rgen E.} and Nielsen, {Troels T.} and Poul Hyttel and Bj{\o}rn Holst and Benjamin Schmid",
note = "Copyright {\textcopyright} 2016. Published by Elsevier B.V.",
year = "2016",
month = nov,
doi = "10.1016/j.scr.2016.09.020",
language = "English",
volume = "17",
pages = "576--579",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Generation of an isogenic, gene-corrected iPSC line from a symptomatic 59-year-old female patient with frontotemporal dementia caused by an R406W mutation in the microtubule associated protein tau (MAPT) gene

AU - Nimsanor, Natakarn

AU - Poulsen, Ulla

AU - Rasmussen, Mikkel A.

AU - Clausen, Christian

AU - Mau-Holzmann, Ulrike A

AU - Nielsen, Jørgen E.

AU - Nielsen, Troels T.

AU - Hyttel, Poul

AU - Holst, Bjørn

AU - Schmid, Benjamin

N1 - Copyright © 2016. Published by Elsevier B.V.

PY - 2016/11

Y1 - 2016/11

N2 - Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the MAPT (microtubule-associated protein tau) gene can cause FTDP-17, but the underlying pathomechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the required cell type. Furthermore, gene-editing approaches allow generating isogenic gene-corrected controls that can be used as a very specific control. Here, we report the generation of genetically corrected iPSCs from a 59-year-old female FTD-17 patient carrying an R406W mutation in the MAPT-gene.

AB - Frontotemporal dementia with parkinsonism linked to chromosome 17q21.2 (FTDP-17) is an autosomal-dominant neurodegenerative disorder. Mutations in the MAPT (microtubule-associated protein tau) gene can cause FTDP-17, but the underlying pathomechanisms of the disease are still unknown. Induced pluripotent stem cells (iPSCs) hold great promise to model FTDP-17 as such cells can be differentiated in vitro to the required cell type. Furthermore, gene-editing approaches allow generating isogenic gene-corrected controls that can be used as a very specific control. Here, we report the generation of genetically corrected iPSCs from a 59-year-old female FTD-17 patient carrying an R406W mutation in the MAPT-gene.

U2 - 10.1016/j.scr.2016.09.020

DO - 10.1016/j.scr.2016.09.020

M3 - Journal article

C2 - 27934586

VL - 17

SP - 576

EP - 579

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

IS - 3

ER -

ID: 172430210