Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse

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Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse. / Hadji-Turdeghal, Katra; Andreasen, Laura; Hagen, Christian M; Ahlberg, Gustav; Ghouse, Jonas; Bækvad-Hansen, Marie; Bybjerg-Grauholm, Jonas; Hougaard, David M; Hedley, Paula; Haunsø, Stig; Svendsen, Jesper H; Kanters, Jørgen K; Jepps, Thomas A; Skov, Morten W; Christiansen, Michael; Olesen, Morten S.

I: Cardiovascular Research, Bind 116, Nr. 1, 2020, s. 138-148.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hadji-Turdeghal, K, Andreasen, L, Hagen, CM, Ahlberg, G, Ghouse, J, Bækvad-Hansen, M, Bybjerg-Grauholm, J, Hougaard, DM, Hedley, P, Haunsø, S, Svendsen, JH, Kanters, JK, Jepps, TA, Skov, MW, Christiansen, M & Olesen, MS 2020, 'Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse', Cardiovascular Research, bind 116, nr. 1, s. 138-148. https://doi.org/10.1093/cvr/cvz106

APA

Hadji-Turdeghal, K., Andreasen, L., Hagen, C. M., Ahlberg, G., Ghouse, J., Bækvad-Hansen, M., Bybjerg-Grauholm, J., Hougaard, D. M., Hedley, P., Haunsø, S., Svendsen, J. H., Kanters, J. K., Jepps, T. A., Skov, M. W., Christiansen, M., & Olesen, M. S. (2020). Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse. Cardiovascular Research, 116(1), 138-148. https://doi.org/10.1093/cvr/cvz106

Vancouver

Hadji-Turdeghal K, Andreasen L, Hagen CM, Ahlberg G, Ghouse J, Bækvad-Hansen M o.a. Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse. Cardiovascular Research. 2020;116(1):138-148. https://doi.org/10.1093/cvr/cvz106

Author

Hadji-Turdeghal, Katra ; Andreasen, Laura ; Hagen, Christian M ; Ahlberg, Gustav ; Ghouse, Jonas ; Bækvad-Hansen, Marie ; Bybjerg-Grauholm, Jonas ; Hougaard, David M ; Hedley, Paula ; Haunsø, Stig ; Svendsen, Jesper H ; Kanters, Jørgen K ; Jepps, Thomas A ; Skov, Morten W ; Christiansen, Michael ; Olesen, Morten S. / Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse. I: Cardiovascular Research. 2020 ; Bind 116, Nr. 1. s. 138-148.

Bibtex

@article{654b871faae1432cab15c1d7ec6c0fad,

title = "Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse",

abstract = "AIMS: Syncope is a common condition associated with frequent hospitalization or visits to the emergency department. Family aggregation and twin studies have shown that syncope has a heritable component. We investigated whether common genetic variants predispose to syncope and collapse.METHODS AND RESULTS: We used genome-wide association data on syncope on 408,961 individuals with European ancestry from the UK Biobank study. In a replication study, we used the Integrative Psychiatric Research Consortium (iPSYCH) cohort (n = 86,189), to investigate the risk of incident syncope stratified by genotype carrier status.We report on a genome-wide significant locus located on chromosome 2q32.1 (odds ratio [OR]= 1.13, 95% confidence interval [CI] 1.10-1.17, P = 5.8x10-15), with lead single nucleotide polymorphism (SNP) rs12465214 in proximity to the gene ZNF804A. This association was also shown in the iPSYCH cohort, where homozygous carriers of the C allele conferred an increased hazard ratio (HR = 1.30, 95% CI 1.15-1.46, P = 1.68x10-5) of incident syncope. qPCR analysis showed ZNF804A to be expressed most abundantly in brain tissue.CONCLUSION: We identified a genome-wide significant locus (rs12465214) associated with syncope and collapse. The association was replicated in an independent cohort. This is the first GWAS to associate a locus with syncope and collapse.",

author = "Katra Hadji-Turdeghal and Laura Andreasen and Hagen, {Christian M} and Gustav Ahlberg and Jonas Ghouse and Marie B{\ae}kvad-Hansen and Jonas Bybjerg-Grauholm and Hougaard, {David M} and Paula Hedley and Stig Hauns{\o} and Svendsen, {Jesper H} and Kanters, {J{\o}rgen K} and Jepps, {Thomas A} and Skov, {Morten W} and Michael Christiansen and Olesen, {Morten S}",

note = "{\textcopyright} The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.",

year = "2020",

doi = "10.1093/cvr/cvz106",

language = "English",

volume = "116",

pages = "138--148",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

number = "1",

}

RIS

TY - JOUR

T1 - Genome-wide association study identifies locus at chromosome 2q32.1 associated with syncope and collapse

AU - Hadji-Turdeghal, Katra

AU - Andreasen, Laura

AU - Hagen, Christian M

AU - Ahlberg, Gustav

AU - Ghouse, Jonas

AU - Bækvad-Hansen, Marie

AU - Bybjerg-Grauholm, Jonas

AU - Hougaard, David M

AU - Hedley, Paula

AU - Haunsø, Stig

AU - Svendsen, Jesper H

AU - Kanters, Jørgen K

AU - Jepps, Thomas A

AU - Skov, Morten W

AU - Christiansen, Michael

AU - Olesen, Morten S

PY - 2020

Y1 - 2020

N2 - AIMS: Syncope is a common condition associated with frequent hospitalization or visits to the emergency department. Family aggregation and twin studies have shown that syncope has a heritable component. We investigated whether common genetic variants predispose to syncope and collapse.METHODS AND RESULTS: We used genome-wide association data on syncope on 408,961 individuals with European ancestry from the UK Biobank study. In a replication study, we used the Integrative Psychiatric Research Consortium (iPSYCH) cohort (n = 86,189), to investigate the risk of incident syncope stratified by genotype carrier status.We report on a genome-wide significant locus located on chromosome 2q32.1 (odds ratio [OR]= 1.13, 95% confidence interval [CI] 1.10-1.17, P = 5.8x10-15), with lead single nucleotide polymorphism (SNP) rs12465214 in proximity to the gene ZNF804A. This association was also shown in the iPSYCH cohort, where homozygous carriers of the C allele conferred an increased hazard ratio (HR = 1.30, 95% CI 1.15-1.46, P = 1.68x10-5) of incident syncope. qPCR analysis showed ZNF804A to be expressed most abundantly in brain tissue.CONCLUSION: We identified a genome-wide significant locus (rs12465214) associated with syncope and collapse. The association was replicated in an independent cohort. This is the first GWAS to associate a locus with syncope and collapse.

AB - AIMS: Syncope is a common condition associated with frequent hospitalization or visits to the emergency department. Family aggregation and twin studies have shown that syncope has a heritable component. We investigated whether common genetic variants predispose to syncope and collapse.METHODS AND RESULTS: We used genome-wide association data on syncope on 408,961 individuals with European ancestry from the UK Biobank study. In a replication study, we used the Integrative Psychiatric Research Consortium (iPSYCH) cohort (n = 86,189), to investigate the risk of incident syncope stratified by genotype carrier status.We report on a genome-wide significant locus located on chromosome 2q32.1 (odds ratio [OR]= 1.13, 95% confidence interval [CI] 1.10-1.17, P = 5.8x10-15), with lead single nucleotide polymorphism (SNP) rs12465214 in proximity to the gene ZNF804A. This association was also shown in the iPSYCH cohort, where homozygous carriers of the C allele conferred an increased hazard ratio (HR = 1.30, 95% CI 1.15-1.46, P = 1.68x10-5) of incident syncope. qPCR analysis showed ZNF804A to be expressed most abundantly in brain tissue.CONCLUSION: We identified a genome-wide significant locus (rs12465214) associated with syncope and collapse. The association was replicated in an independent cohort. This is the first GWAS to associate a locus with syncope and collapse.

U2 - 10.1093/cvr/cvz106

DO - 10.1093/cvr/cvz106

M3 - Journal article

C2 - 31049583

VL - 116

SP - 138

EP - 148

JO - Cardiovascular Research

JF - Cardiovascular Research

SN - 0008-6363

IS - 1

ER -

ID: 221835741

Institut for Klinisk Medicin