Healthcare utilization prior to a diagnosis of young-onset Alzheimer’s disease: a nationwide nested case–control study
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Healthcare utilization prior to a diagnosis of young-onset Alzheimer’s disease : a nationwide nested case–control study. / Damsgaard, Line; Janbek, Janet; Laursen, Thomas Munk; Waldemar, Gunhild; Jensen-Dahm, Christina.
I: Journal of Neurology, Bind 270, Nr. 12, 2023, s. 6093-6102.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Healthcare utilization prior to a diagnosis of young-onset Alzheimer’s disease
T2 - a nationwide nested case–control study
AU - Damsgaard, Line
AU - Janbek, Janet
AU - Laursen, Thomas Munk
AU - Waldemar, Gunhild
AU - Jensen-Dahm, Christina
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - Objective: Our aim was to identify changes in healthcare utilization prior to a young-onset Alzheimer’s disease diagnosis. Methods: In a retrospective incidence density matched nested case–control study using national health registers, we examined healthcare utilization for those diagnosed with young-onset Alzheimer’s disease in Danish memory clinics during 2016–2018 compared with age- and sex-matched controls. Negative binomial regression analysis produced contact rate ratios. Results: The study included 1082 young-onset Alzheimer’s disease patients and 3246 controls. In the year preceding diagnosis, we found increased contact rate ratios for all types of contacts except physiotherapy. Contact rate ratios for contacts with a general practitioner were significantly increased also > 1–5 and > 5–10 years before diagnosis. The highest contact rate ratios were for psychiatric emergency contacts (8.69, 95% CI 4.29–17.62) ≤ 1 year before diagnosis. Interpretation: Results demonstrate that young-onset Alzheimer’s disease patients have increased healthcare utilization from 5 to 10 years prior to diagnosis. Awareness of specific alterations in health-seeking behaviour may help healthcare professionals provide timely diagnoses.
AB - Objective: Our aim was to identify changes in healthcare utilization prior to a young-onset Alzheimer’s disease diagnosis. Methods: In a retrospective incidence density matched nested case–control study using national health registers, we examined healthcare utilization for those diagnosed with young-onset Alzheimer’s disease in Danish memory clinics during 2016–2018 compared with age- and sex-matched controls. Negative binomial regression analysis produced contact rate ratios. Results: The study included 1082 young-onset Alzheimer’s disease patients and 3246 controls. In the year preceding diagnosis, we found increased contact rate ratios for all types of contacts except physiotherapy. Contact rate ratios for contacts with a general practitioner were significantly increased also > 1–5 and > 5–10 years before diagnosis. The highest contact rate ratios were for psychiatric emergency contacts (8.69, 95% CI 4.29–17.62) ≤ 1 year before diagnosis. Interpretation: Results demonstrate that young-onset Alzheimer’s disease patients have increased healthcare utilization from 5 to 10 years prior to diagnosis. Awareness of specific alterations in health-seeking behaviour may help healthcare professionals provide timely diagnoses.
KW - Alzheimer’s disease
KW - Early warning signs
KW - Epidemiology
KW - Healthcare utilization
KW - Registry-based
KW - Young-onset dementia
U2 - 10.1007/s00415-023-11974-x
DO - 10.1007/s00415-023-11974-x
M3 - Journal article
C2 - 37668703
AN - SCOPUS:85169831719
VL - 270
SP - 6093
EP - 6102
JO - Deutsche Zeitschrift fur Nervenheilkunde
JF - Deutsche Zeitschrift fur Nervenheilkunde
SN - 0939-1517
IS - 12
ER -
ID: 376377313