Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases. / Markey, Keira A; Uldall, Maria; Botfield, Hannah; Cato, Liam D.; Miah, Mohammed A.L.; Hassan-Smith, Ghaniah; Jensen, Rigmor H.; Gonzalez, Ana M; Sinclair, Alexandra J.

I: Journal of Pain Research, Bind 9, 2016, s. 223-232.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Markey, KA, Uldall, M, Botfield, H, Cato, LD, Miah, MAL, Hassan-Smith, G, Jensen, RH, Gonzalez, AM & Sinclair, AJ 2016, 'Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases', Journal of Pain Research, bind 9, s. 223-232. https://doi.org/10.2147/JPR.S80824

APA

Markey, K. A., Uldall, M., Botfield, H., Cato, L. D., Miah, M. A. L., Hassan-Smith, G., Jensen, R. H., Gonzalez, A. M., & Sinclair, A. J. (2016). Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases. Journal of Pain Research, 9, 223-232. https://doi.org/10.2147/JPR.S80824

Vancouver

Markey KA, Uldall M, Botfield H, Cato LD, Miah MAL, Hassan-Smith G o.a. Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases. Journal of Pain Research. 2016;9:223-232. https://doi.org/10.2147/JPR.S80824

Author

Markey, Keira A ; Uldall, Maria ; Botfield, Hannah ; Cato, Liam D. ; Miah, Mohammed A.L. ; Hassan-Smith, Ghaniah ; Jensen, Rigmor H. ; Gonzalez, Ana M ; Sinclair, Alexandra J. / Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases. I: Journal of Pain Research. 2016 ; Bind 9. s. 223-232.

Bibtex

@article{312dad662ab9494a8297544a5566a234,
title = "Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases",
abstract = "Idiopathic intracranial hypertension (IIH) results in raised intracranial pressure (ICP) leading to papilledema, visual dysfunction, and headaches. Obese females of reproductive age are predominantly affected, but the underlying pathological mechanisms behind IIH remain unknown. This review provides an overview of pathogenic factors that could result in IIH with particular focus on hormones and the impact of obesity, including its role in neuroendocrine signaling and driving inflammation. Despite occurring almost exclusively in obese women, there have been a few studies evaluating the mechanisms by which hormones and adipokines exert their effects on ICP regulation in IIH. Research involving 11β-hydroxysteroid dehydrogenase type 1, a modulator of glucocorticoids, suggests a potential role in IIH. Improved understanding of the complex interplay between adipose signaling factors such as adipokines, steroid hormones, and ICP regulation may be key to the understanding and future management of IIH.",
keywords = "11beta-hydroxysteroid dehydrogenase type 1, Leptin, Obesity, Steroid and adipokines",
author = "Markey, {Keira A} and Maria Uldall and Hannah Botfield and Cato, {Liam D.} and Miah, {Mohammed A.L.} and Ghaniah Hassan-Smith and Jensen, {Rigmor H.} and Gonzalez, {Ana M} and Sinclair, {Alexandra J}",
year = "2016",
doi = "10.2147/JPR.S80824",
language = "English",
volume = "9",
pages = "223--232",
journal = "Journal of Pain Research",
issn = "1178-7090",
publisher = "Dove Medical Press",

}

RIS

TY - JOUR

T1 - Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases

AU - Markey, Keira A

AU - Uldall, Maria

AU - Botfield, Hannah

AU - Cato, Liam D.

AU - Miah, Mohammed A.L.

AU - Hassan-Smith, Ghaniah

AU - Jensen, Rigmor H.

AU - Gonzalez, Ana M

AU - Sinclair, Alexandra J

PY - 2016

Y1 - 2016

N2 - Idiopathic intracranial hypertension (IIH) results in raised intracranial pressure (ICP) leading to papilledema, visual dysfunction, and headaches. Obese females of reproductive age are predominantly affected, but the underlying pathological mechanisms behind IIH remain unknown. This review provides an overview of pathogenic factors that could result in IIH with particular focus on hormones and the impact of obesity, including its role in neuroendocrine signaling and driving inflammation. Despite occurring almost exclusively in obese women, there have been a few studies evaluating the mechanisms by which hormones and adipokines exert their effects on ICP regulation in IIH. Research involving 11β-hydroxysteroid dehydrogenase type 1, a modulator of glucocorticoids, suggests a potential role in IIH. Improved understanding of the complex interplay between adipose signaling factors such as adipokines, steroid hormones, and ICP regulation may be key to the understanding and future management of IIH.

AB - Idiopathic intracranial hypertension (IIH) results in raised intracranial pressure (ICP) leading to papilledema, visual dysfunction, and headaches. Obese females of reproductive age are predominantly affected, but the underlying pathological mechanisms behind IIH remain unknown. This review provides an overview of pathogenic factors that could result in IIH with particular focus on hormones and the impact of obesity, including its role in neuroendocrine signaling and driving inflammation. Despite occurring almost exclusively in obese women, there have been a few studies evaluating the mechanisms by which hormones and adipokines exert their effects on ICP regulation in IIH. Research involving 11β-hydroxysteroid dehydrogenase type 1, a modulator of glucocorticoids, suggests a potential role in IIH. Improved understanding of the complex interplay between adipose signaling factors such as adipokines, steroid hormones, and ICP regulation may be key to the understanding and future management of IIH.

KW - 11beta-hydroxysteroid dehydrogenase type 1

KW - Leptin

KW - Obesity

KW - Steroid and adipokines

U2 - 10.2147/JPR.S80824

DO - 10.2147/JPR.S80824

M3 - Review

C2 - 27186074

AN - SCOPUS:84964555208

VL - 9

SP - 223

EP - 232

JO - Journal of Pain Research

JF - Journal of Pain Research

SN - 1178-7090

ER -

ID: 179126339