TY - JOUR

T1 - Impact of 3 Tesla MRI on interobserver agreement in clinically isolated syndrome

T2 - A MAGNIMS multicentre study

AU - Hagens, Marloes H.J.

AU - Burggraaff, Jessica

AU - Kilsdonk, Iris D.

AU - Ruggieri, Serena

AU - Collorone, Sara

AU - Cortese, Rosa

AU - Cawley, Niamh

AU - Sbardella, Emilia

AU - Andelova, Michaela

AU - Amann, Michael

AU - Lieb, Johanna M.

AU - Pantano, Patrizia

AU - Lissenberg-Witte, Birgit I.

AU - Killestein, Joep

AU - Oreja-Guevara, Celia

AU - Wuerfel, Jens

AU - Ciccarelli, Olga

AU - Gasperini, Claudio

AU - Lukas, Carsten

AU - Rovira, Alex

AU - Barkhof, Frederik

AU - Wattjes, Mike P.

AU - For the MAGNIMS Study Group

AU - Barkhof, Frederik

AU - Ciccarelli, Olga

AU - Yousry, Tarek

AU - Fredriksen, Jette Lautrup

AU - Rovira, Alex

AU - Sastre-Garriga, Jaume

AU - Vrenken, Hugo

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. Objectives: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. Methods: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort. All subjects received baseline 1.5 and 3 T brain and spinal cord MRI. Patients also received follow-up brain MRI at 3–6 months. Four experienced neuroradiologists and four less-experienced raters scored the number of lesions per anatomical region and determined dissemination in space and time (McDonald 2010). Results: In controls, the mean number of lesions per rater was 0.16 at 1.5 T and 0.38 at 3 T (p = 0.005). For patients, this was 4.18 and 4.40, respectively (p = 0.657). Inter-rater agreement on involvement per anatomical region and dissemination in space and time was moderate to good for both field strengths. 3 T slightly improved agreement between experienced raters, but slightly decreased agreement between less-experienced raters. Conclusion: Overall, the interobserver agreement was moderate to good. 3 T appears to improve the reading for experienced readers, underlining the benefit of additional training.

AB - Background: Compared to 1.5 T, 3 T magnetic resonance imaging (MRI) increases signal-to-noise ratio leading to improved image quality. However, its clinical relevance in clinically isolated syndrome suggestive of multiple sclerosis remains uncertain. Objectives: The purpose of this study was to investigate how 3 T MRI affects the agreement between raters on lesion detection and diagnosis. Methods: We selected 30 patients and 10 healthy controls from our ongoing prospective multicentre cohort. All subjects received baseline 1.5 and 3 T brain and spinal cord MRI. Patients also received follow-up brain MRI at 3–6 months. Four experienced neuroradiologists and four less-experienced raters scored the number of lesions per anatomical region and determined dissemination in space and time (McDonald 2010). Results: In controls, the mean number of lesions per rater was 0.16 at 1.5 T and 0.38 at 3 T (p = 0.005). For patients, this was 4.18 and 4.40, respectively (p = 0.657). Inter-rater agreement on involvement per anatomical region and dissemination in space and time was moderate to good for both field strengths. 3 T slightly improved agreement between experienced raters, but slightly decreased agreement between less-experienced raters. Conclusion: Overall, the interobserver agreement was moderate to good. 3 T appears to improve the reading for experienced readers, underlining the benefit of additional training.

KW - clinically isolated syndrome

KW - interobserver variation

KW - magnetic resonance imaging

KW - multicentre study

KW - Multiple sclerosis

U2 - 10.1177/1352458517751647

DO - 10.1177/1352458517751647

M3 - Journal article

C2 - 29327668

AN - SCOPUS:85043357834

VL - 25

SP - 352

EP - 360

JO - Multiple Sclerosis Journal

JF - Multiple Sclerosis Journal

SN - 1352-4585

IS - 3

ER -