Increased immunopotency of monocyte derived dendritic cells from patients with optic neuritis is inhibited in vitro by simvastatin
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Increased immunopotency of monocyte derived dendritic cells from patients with optic neuritis is inhibited in vitro by simvastatin. / Tsakiri, Anna; Tsiantoulas, Dimitris; Frederiksen, Jette; Svane, Inge Marie.
I: Experimental Neurology, Bind 221, Nr. 2, 01.02.2010, s. 320-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Increased immunopotency of monocyte derived dendritic cells from patients with optic neuritis is inhibited in vitro by simvastatin
AU - Tsakiri, Anna
AU - Tsiantoulas, Dimitris
AU - Frederiksen, Jette
AU - Svane, Inge Marie
N1 - Copyright 2009 Elsevier Inc. All rights reserved.
PY - 2010/2/1
Y1 - 2010/2/1
N2 - Multiple sclerosis (MS) is an autoimmune disease where myelin-reactive lymphocytes and their activation depend on interactions with antigen presenting cells (APCs). Dendritic cells (DC) are professional APCs dependent on maturation to attain full T-cell priming capacity. The immunomodulatory properties of simvastatin influence the function of both T cells and APCs and could thus be a potential therapy for MS. The phenotype of myeloid DC in untreated patients with monosymptomatic optic neuritis (ON) was determined by flow cytometry and the impact of simvastatin on the function of myeloid DC derived from peripheral blood mononuclear cells (PBMC) was analysed in vitro. DC from ON patients had more mature phenotype compared with healthy controls (HC). Particularly the fraction of DC expressing CD1a and CD80 was significantly higher in ON than in HC (P
AB - Multiple sclerosis (MS) is an autoimmune disease where myelin-reactive lymphocytes and their activation depend on interactions with antigen presenting cells (APCs). Dendritic cells (DC) are professional APCs dependent on maturation to attain full T-cell priming capacity. The immunomodulatory properties of simvastatin influence the function of both T cells and APCs and could thus be a potential therapy for MS. The phenotype of myeloid DC in untreated patients with monosymptomatic optic neuritis (ON) was determined by flow cytometry and the impact of simvastatin on the function of myeloid DC derived from peripheral blood mononuclear cells (PBMC) was analysed in vitro. DC from ON patients had more mature phenotype compared with healthy controls (HC). Particularly the fraction of DC expressing CD1a and CD80 was significantly higher in ON than in HC (P
U2 - http://dx.doi.org/10.1016/j.expneurol.2009.11.014
DO - http://dx.doi.org/10.1016/j.expneurol.2009.11.014
M3 - Journal article
VL - 221
SP - 320
EP - 328
JO - Experimental Neurology
JF - Experimental Neurology
SN - 0014-4886
IS - 2
ER -
ID: 34073508