Increased short- and long-term mortality following infections in dementia: a nationwide registry-based cohort study
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Increased short- and long-term mortality following infections in dementia : a nationwide registry-based cohort study. / Janbek, J.; Taudorf, L.; Musaeus, C. S.; Frimodt-Møller, N.; Laursen, T. M.; Waldemar, G.
I: European Journal of Neurology, Bind 28, Nr. 2, 2021, s. 411-420.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Increased short- and long-term mortality following infections in dementia
T2 - a nationwide registry-based cohort study
AU - Janbek, J.
AU - Taudorf, L.
AU - Musaeus, C. S.
AU - Frimodt-Møller, N.
AU - Laursen, T. M.
AU - Waldemar, G.
PY - 2021
Y1 - 2021
N2 - Background and purpose: Mortality following infections in dementia has not yet been comprehensively explored. The aim of this cohort study was to investigate the short- and long-term mortality following infections in dementia. Methods: Follow-up was from 1 January 2000 or the 65-year birthday until death, immigration, or 31 December 2015. Exposure was incident dementia and a first infection. The outcome was all-cause mortality. Mortality rate ratios (MRRs) were calculated using Poisson regression in 4 exposure groups (dementia yes/no, infection yes/no) by sex, infection site, and time since infection. Results: 1,496,436 people were followed with 12,739,135 person-years. MRR in dementia/infection was 6.52 (95% confidence interval: 6.43–6.60) and was increased for infections of all sites. Increased mortality was short term (30 days) and long term (10 years). Conclusions: Increased mortality in people with dementia identifies them as a particularly vulnerable group that needs clinical attention.
AB - Background and purpose: Mortality following infections in dementia has not yet been comprehensively explored. The aim of this cohort study was to investigate the short- and long-term mortality following infections in dementia. Methods: Follow-up was from 1 January 2000 or the 65-year birthday until death, immigration, or 31 December 2015. Exposure was incident dementia and a first infection. The outcome was all-cause mortality. Mortality rate ratios (MRRs) were calculated using Poisson regression in 4 exposure groups (dementia yes/no, infection yes/no) by sex, infection site, and time since infection. Results: 1,496,436 people were followed with 12,739,135 person-years. MRR in dementia/infection was 6.52 (95% confidence interval: 6.43–6.60) and was increased for infections of all sites. Increased mortality was short term (30 days) and long term (10 years). Conclusions: Increased mortality in people with dementia identifies them as a particularly vulnerable group that needs clinical attention.
KW - dementia
KW - epidemiology
KW - infection
KW - mortality
KW - registry-based study
U2 - 10.1111/ene.14595
DO - 10.1111/ene.14595
M3 - Journal article
C2 - 33065766
AN - SCOPUS:85096708310
VL - 28
SP - 411
EP - 420
JO - European Journal of Neurology
JF - European Journal of Neurology
SN - 1351-5101
IS - 2
ER -
ID: 252722642