Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT)

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT). / Rasmussen, Mikkel A.; Hjermind, Lena E.; Hasholt, Lis F.; Waldemar, Gunhild; Nielsen, Jorgen E.; Clausen, Christian; Hyttel, Poul; Holst, Bjørn.

I: Stem Cell Research, Bind 16, Nr. 1, 01.2016, s. 75-78.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Rasmussen, MA, Hjermind, LE, Hasholt, LF, Waldemar, G, Nielsen, JE, Clausen, C, Hyttel, P & Holst, B 2016, 'Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT)', Stem Cell Research, bind 16, nr. 1, s. 75-78. https://doi.org/10.1016/j.scr.2015.12.006

APA

Rasmussen, M. A., Hjermind, L. E., Hasholt, L. F., Waldemar, G., Nielsen, J. E., Clausen, C., Hyttel, P., & Holst, B. (2016). Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT). Stem Cell Research, 16(1), 75-78. https://doi.org/10.1016/j.scr.2015.12.006

Vancouver

Rasmussen MA, Hjermind LE, Hasholt LF, Waldemar G, Nielsen JE, Clausen C o.a. Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT). Stem Cell Research. 2016 jan.;16(1):75-78. https://doi.org/10.1016/j.scr.2015.12.006

Author

Rasmussen, Mikkel A. ; Hjermind, Lena E. ; Hasholt, Lis F. ; Waldemar, Gunhild ; Nielsen, Jorgen E. ; Clausen, Christian ; Hyttel, Poul ; Holst, Bjørn. / Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT). I: Stem Cell Research. 2016 ; Bind 16, Nr. 1. s. 75-78.

Bibtex

@article{4d3469b818804329b61b9e8e3b09b9ed,
title = "Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT)",
abstract = "Skin fibroblasts were obtained from a 59-year-old woman diagnosed with frontotemporal dementia. The disease is caused by a R406W mutation in microtubule-associated protein tau (MAPT). Induced pluripotent stem cells (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. iPSCs were free of genomically integrated reprogramming genes, contained the expected c.1216C > T substitution in exon 13 of the MAPT gene, expressed the expected pluripotency markers, displayed in vitro differentiation potential to the three germ layers and had normal karyotype. The iPSC line may be useful for studying hereditary frontotemporal dementia and TAU pathology in vitro.",
author = "Rasmussen, {Mikkel A.} and Hjermind, {Lena E.} and Hasholt, {Lis F.} and Gunhild Waldemar and Nielsen, {Jorgen E.} and Christian Clausen and Poul Hyttel and Bj{\o}rn Holst",
year = "2016",
month = jan,
doi = "10.1016/j.scr.2015.12.006",
language = "English",
volume = "16",
pages = "75--78",
journal = "Stem Cell Research",
issn = "1873-5061",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Induced pluripotent stem cells (iPSCs) derived from a patient with frontotemporal dementia caused by a R406W mutation in microtubule-associated protein tau (MAPT)

AU - Rasmussen, Mikkel A.

AU - Hjermind, Lena E.

AU - Hasholt, Lis F.

AU - Waldemar, Gunhild

AU - Nielsen, Jorgen E.

AU - Clausen, Christian

AU - Hyttel, Poul

AU - Holst, Bjørn

PY - 2016/1

Y1 - 2016/1

N2 - Skin fibroblasts were obtained from a 59-year-old woman diagnosed with frontotemporal dementia. The disease is caused by a R406W mutation in microtubule-associated protein tau (MAPT). Induced pluripotent stem cells (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. iPSCs were free of genomically integrated reprogramming genes, contained the expected c.1216C > T substitution in exon 13 of the MAPT gene, expressed the expected pluripotency markers, displayed in vitro differentiation potential to the three germ layers and had normal karyotype. The iPSC line may be useful for studying hereditary frontotemporal dementia and TAU pathology in vitro.

AB - Skin fibroblasts were obtained from a 59-year-old woman diagnosed with frontotemporal dementia. The disease is caused by a R406W mutation in microtubule-associated protein tau (MAPT). Induced pluripotent stem cells (iPSCs) were established by electroporation with episomal plasmids containing hOCT4, hSOX2, hKLF2, hL-MYC, hLIN-28 and shP53. iPSCs were free of genomically integrated reprogramming genes, contained the expected c.1216C > T substitution in exon 13 of the MAPT gene, expressed the expected pluripotency markers, displayed in vitro differentiation potential to the three germ layers and had normal karyotype. The iPSC line may be useful for studying hereditary frontotemporal dementia and TAU pathology in vitro.

U2 - 10.1016/j.scr.2015.12.006

DO - 10.1016/j.scr.2015.12.006

M3 - Journal article

C2 - 27345789

VL - 16

SP - 75

EP - 78

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

IS - 1

ER -

ID: 167477844