TY - JOUR

T1 - Long-Term EEG Monitoring in Patients with Alzheimer's Disease Using Ear-EEG

T2 - A Feasibility Study

AU - Musaeus, Christian Sandøe

AU - Waldemar, Gunhild

AU - Andersen, Birgitte Bo

AU - Høgh, Peter

AU - Kidmose, Preben

AU - Hemmsen, Martin Christian

AU - Rank, Mike Lind

AU - Kjær, Troels Wesenberg

AU - Frederiksen, Kristian Steen

N1 - Publisher Copyright: © 2022 - IOS Press. All rights reserved.

PY - 2022

Y1 - 2022

N2 - Background: Previous studies have reported that epileptiform activity may be detectible in nearly half of patients with Alzheimer's disease (AD) on long-term electroencephalographic (EEG) recordings. However, such recordings can be uncomfortable, expensive, and difficult. Ear-EEG has shown promising results for long-term EEG monitoring, but it has not been used in patients with AD. Objective: To investigate if ear-EEG is a feasible method for long-term EEG monitoring in patients with AD. Methods: In this longitudinal, single-group feasibility study, ten patients with mild to moderate AD were recruited. A total of three ear-EEG recordings of up to 48 hours three months apart for six months were planned. Results: All patients managed to wear the ear-EEG for at least 24 hours and at least one full night. A total of 19 ear-EEG recordings were performed (self-reported recording, mean: 37.15 hours (SD: 8.96 hours)). After automatic pre-processing, a mean of 27.37 hours (SD: 7.19 hours) of data with acceptable quality in at least one electrode in each ear was found. Seven out of ten participants experienced mild adverse events. Six of the patients did not complete the study with three patients not wanting to wear the ear-EEG anymore due to adverse events. Conclusion: It is feasible and safe to use ear-EEG for long-term EEG monitoring in patients with AD. Minor adjustments to the equipment may improve the comfort for the participants.

AB - Background: Previous studies have reported that epileptiform activity may be detectible in nearly half of patients with Alzheimer's disease (AD) on long-term electroencephalographic (EEG) recordings. However, such recordings can be uncomfortable, expensive, and difficult. Ear-EEG has shown promising results for long-term EEG monitoring, but it has not been used in patients with AD. Objective: To investigate if ear-EEG is a feasible method for long-term EEG monitoring in patients with AD. Methods: In this longitudinal, single-group feasibility study, ten patients with mild to moderate AD were recruited. A total of three ear-EEG recordings of up to 48 hours three months apart for six months were planned. Results: All patients managed to wear the ear-EEG for at least 24 hours and at least one full night. A total of 19 ear-EEG recordings were performed (self-reported recording, mean: 37.15 hours (SD: 8.96 hours)). After automatic pre-processing, a mean of 27.37 hours (SD: 7.19 hours) of data with acceptable quality in at least one electrode in each ear was found. Seven out of ten participants experienced mild adverse events. Six of the patients did not complete the study with three patients not wanting to wear the ear-EEG anymore due to adverse events. Conclusion: It is feasible and safe to use ear-EEG for long-term EEG monitoring in patients with AD. Minor adjustments to the equipment may improve the comfort for the participants.

KW - Alzheimer's disease

KW - ear-EEG

KW - electroencephalography

KW - long-term EEG

KW - wearable

U2 - 10.3233/JAD-220491

DO - 10.3233/JAD-220491

M3 - Journal article

C2 - 36336927

AN - SCOPUS:85143917022

VL - 90

SP - 1713

EP - 1723

JO - Journal of Alzheimer's Disease

JF - Journal of Alzheimer's Disease

SN - 1387-2877

IS - 4

ER -