MAIT cell subtypes in multiple sclerosis

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

MAIT cell subtypes in multiple sclerosis. / Ammitzbøll, Cecilie; von Essen, Marina R.; Chow, Helene Højsgaard; McWilliam, Oskar; Holm Hansen, Rikke; Sellebjerg, Finn.

I: Journal of Neuroimmunology, Bind 339, 577117, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ammitzbøll, C, von Essen, MR, Chow, HH, McWilliam, O, Holm Hansen, R & Sellebjerg, F 2020, 'MAIT cell subtypes in multiple sclerosis', Journal of Neuroimmunology, bind 339, 577117. https://doi.org/10.1016/j.jneuroim.2019.577117

APA

Ammitzbøll, C., von Essen, M. R., Chow, H. H., McWilliam, O., Holm Hansen, R., & Sellebjerg, F. (2020). MAIT cell subtypes in multiple sclerosis. Journal of Neuroimmunology, 339, [577117]. https://doi.org/10.1016/j.jneuroim.2019.577117

Vancouver

Ammitzbøll C, von Essen MR, Chow HH, McWilliam O, Holm Hansen R, Sellebjerg F. MAIT cell subtypes in multiple sclerosis. Journal of Neuroimmunology. 2020;339. 577117. https://doi.org/10.1016/j.jneuroim.2019.577117

Author

Ammitzbøll, Cecilie ; von Essen, Marina R. ; Chow, Helene Højsgaard ; McWilliam, Oskar ; Holm Hansen, Rikke ; Sellebjerg, Finn. / MAIT cell subtypes in multiple sclerosis. I: Journal of Neuroimmunology. 2020 ; Bind 339.

Bibtex

@article{9fa739b232324a5eb7ef586277acb6c7,
title = "MAIT cell subtypes in multiple sclerosis",
abstract = "In patients with multiple sclerosis (MS) and healthy controls (HC) we studied circulating MAIT cells and MAIT cell subtypes expressing CXCR3 and CCR6 by flow cytometry. Absolute numbers of MAIT cells and specifically Tc17-like MAIT cells were lower in patients with primary progressive MS (PPMS) than in controls. Low numbers of Tc17-like MAIT cells were associated with smoking and high concentrations of myelin basic protein in the cerebrospinal fluid. Treatment with alemtuzumab and dimethyl fumarate decreased MAIT cell frequencies. Altogether, we have identified specific MAIT cell subtypes related to PPMS, smoking and demyelination, and MAIT cell effects of MS therapies.",
author = "Cecilie Ammitzb{\o}ll and {von Essen}, {Marina R.} and Chow, {Helene H{\o}jsgaard} and Oskar McWilliam and {Holm Hansen}, Rikke and Finn Sellebjerg",
year = "2020",
doi = "10.1016/j.jneuroim.2019.577117",
language = "English",
volume = "339",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - MAIT cell subtypes in multiple sclerosis

AU - Ammitzbøll, Cecilie

AU - von Essen, Marina R.

AU - Chow, Helene Højsgaard

AU - McWilliam, Oskar

AU - Holm Hansen, Rikke

AU - Sellebjerg, Finn

PY - 2020

Y1 - 2020

N2 - In patients with multiple sclerosis (MS) and healthy controls (HC) we studied circulating MAIT cells and MAIT cell subtypes expressing CXCR3 and CCR6 by flow cytometry. Absolute numbers of MAIT cells and specifically Tc17-like MAIT cells were lower in patients with primary progressive MS (PPMS) than in controls. Low numbers of Tc17-like MAIT cells were associated with smoking and high concentrations of myelin basic protein in the cerebrospinal fluid. Treatment with alemtuzumab and dimethyl fumarate decreased MAIT cell frequencies. Altogether, we have identified specific MAIT cell subtypes related to PPMS, smoking and demyelination, and MAIT cell effects of MS therapies.

AB - In patients with multiple sclerosis (MS) and healthy controls (HC) we studied circulating MAIT cells and MAIT cell subtypes expressing CXCR3 and CCR6 by flow cytometry. Absolute numbers of MAIT cells and specifically Tc17-like MAIT cells were lower in patients with primary progressive MS (PPMS) than in controls. Low numbers of Tc17-like MAIT cells were associated with smoking and high concentrations of myelin basic protein in the cerebrospinal fluid. Treatment with alemtuzumab and dimethyl fumarate decreased MAIT cell frequencies. Altogether, we have identified specific MAIT cell subtypes related to PPMS, smoking and demyelination, and MAIT cell effects of MS therapies.

U2 - 10.1016/j.jneuroim.2019.577117

DO - 10.1016/j.jneuroim.2019.577117

M3 - Journal article

C2 - 31812897

AN - SCOPUS:85075861283

VL - 339

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

M1 - 577117

ER -

ID: 250250853