Moderate-to-high intensity physical exercise in patients with Alzheimer’s disease: a randomised controlled trial.
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Moderate-to-high intensity physical exercise in patients with Alzheimer’s disease : a randomised controlled trial. / Hoffmann, Kristine; Sobol, Nanna A.; Frederiksen, Kristian S.; Beyer, Nina Ann-Marie; Vogel, Asmus Mejling; Vestergaard, Karsten; Brændgaard, Hans; Gottrup, Hanne; Lolk, Annette; Wermuth, Lene; Jacobsen, Søren; Laugesen, Lars P.; Gergelyffy, Robert G.; Høgh, Peter; Bjerregaard, Eva; Andersen, Birgitte Bo; Siersma, Volkert Dirk; Johannsen, Peter; Cotman, Carl W; Waldemar, Gunhild; Hasselbalch, Steen.
I: Journal of Alzheimer's Disease, Bind 50, Nr. 2, 2016, s. 443-453.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Moderate-to-high intensity physical exercise in patients with Alzheimer’s disease
T2 - a randomised controlled trial.
AU - Hoffmann, Kristine
AU - Sobol, Nanna A.
AU - Frederiksen, Kristian S.
AU - Beyer, Nina Ann-Marie
AU - Vogel, Asmus Mejling
AU - Vestergaard, Karsten
AU - Brændgaard, Hans
AU - Gottrup, Hanne
AU - Lolk, Annette
AU - Wermuth, Lene
AU - Jacobsen, Søren
AU - Laugesen, Lars P.
AU - Gergelyffy, Robert G.
AU - Høgh, Peter
AU - Bjerregaard, Eva
AU - Andersen, Birgitte Bo
AU - Siersma, Volkert Dirk
AU - Johannsen, Peter
AU - Cotman, Carl W
AU - Waldemar, Gunhild
AU - Hasselbalch, Steen
PY - 2016
Y1 - 2016
N2 - Background: Studies of physical exercise in patients with Alzheimer’s disease (AD) are few and results have been inconsistent.Objective: To assess the effects of a moderate-to-high intensity aerobic exercise program in patients with mild AD.Methods: In a randomized controlled trial, we recruited 200 patients with mild AD to a supervised exercise group (60-min sessions three times a week for 16 weeks) or to a control group. Primary outcome was changed from baseline in cognitive performance estimated by Symbol Digit Modalities Test (SDMT) in the intention-to-treat (ITT) group. Secondary outcomes included changes in quality of life, ability to perform activities of daily living, and in neuropsychiatric and depressive symptoms. Results: The ITT analysis showed no significant differences between intervention and control groups in change from baseline of SDMT, other cognitive tests, quality of life, or activities of daily living. The change from baseline in Neuropsychiatric Inventory differed significantly in favor of the intervention group (mean: –3.5, 95% confidence interval (CI) –5.8 to –1.3, p = 0.002). In subjects who adhered to the protocol, we found a significant effect on change from baseline in SDMT as compared with the control group (mean: 4.2, 95% CI 0.5 to 7.9, p = 0.028), suggesting a dose-response relationship between exercise and cognition.Conclusions: This is the first randomized controlled trial with supervised moderate-to-high intensity exercise in patients with mild AD. Exercise reduced neuropsychiatric symptoms in patients with mild AD, with possible additional benefits of preserved cognition in a subgroup of patients exercising with high attendance and intensity.
AB - Background: Studies of physical exercise in patients with Alzheimer’s disease (AD) are few and results have been inconsistent.Objective: To assess the effects of a moderate-to-high intensity aerobic exercise program in patients with mild AD.Methods: In a randomized controlled trial, we recruited 200 patients with mild AD to a supervised exercise group (60-min sessions three times a week for 16 weeks) or to a control group. Primary outcome was changed from baseline in cognitive performance estimated by Symbol Digit Modalities Test (SDMT) in the intention-to-treat (ITT) group. Secondary outcomes included changes in quality of life, ability to perform activities of daily living, and in neuropsychiatric and depressive symptoms. Results: The ITT analysis showed no significant differences between intervention and control groups in change from baseline of SDMT, other cognitive tests, quality of life, or activities of daily living. The change from baseline in Neuropsychiatric Inventory differed significantly in favor of the intervention group (mean: –3.5, 95% confidence interval (CI) –5.8 to –1.3, p = 0.002). In subjects who adhered to the protocol, we found a significant effect on change from baseline in SDMT as compared with the control group (mean: 4.2, 95% CI 0.5 to 7.9, p = 0.028), suggesting a dose-response relationship between exercise and cognition.Conclusions: This is the first randomized controlled trial with supervised moderate-to-high intensity exercise in patients with mild AD. Exercise reduced neuropsychiatric symptoms in patients with mild AD, with possible additional benefits of preserved cognition in a subgroup of patients exercising with high attendance and intensity.
U2 - 10.3233/JAD-150817
DO - 10.3233/JAD-150817
M3 - Journal article
C2 - 26682695
VL - 50
SP - 443
EP - 453
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 2
ER -
ID: 157322032