Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

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Standard

Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system. / Sørensen, Torben Lykke; Trebst, Corinna; Kivisäkk, Pia; Klaege, Karen L; Majmudar, Amit; Ravid, Rivka; Lassmann, Hans; Olsen, David B; Strieter, Robert M; Ransohoff, Richard M; Sellebjerg, Finn.

I: Journal of Neuroimmunology, Bind 127, Nr. 1-2, 06.2002, s. 59-68.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning

Harvard

Sørensen, TL, Trebst, C, Kivisäkk, P, Klaege, KL, Majmudar, A, Ravid, R, Lassmann, H, Olsen, DB, Strieter, RM, Ransohoff, RM & Sellebjerg, F 2002, 'Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system', Journal of Neuroimmunology, bind 127, nr. 1-2, s. 59-68.

APA

Sørensen, T. L., Trebst, C., Kivisäkk, P., Klaege, K. L., Majmudar, A., Ravid, R., Lassmann, H., Olsen, D. B., Strieter, R. M., Ransohoff, R. M., & Sellebjerg, F. (2002). Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system. Journal of Neuroimmunology, 127(1-2), 59-68.

Vancouver

Sørensen TL, Trebst C, Kivisäkk P, Klaege KL, Majmudar A, Ravid R o.a. Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system. Journal of Neuroimmunology. 2002 jun.;127(1-2):59-68.

Author

Sørensen, Torben Lykke ; Trebst, Corinna ; Kivisäkk, Pia ; Klaege, Karen L ; Majmudar, Amit ; Ravid, Rivka ; Lassmann, Hans ; Olsen, David B ; Strieter, Robert M ; Ransohoff, Richard M ; Sellebjerg, Finn. / Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system. I: Journal of Neuroimmunology. 2002 ; Bind 127, Nr. 1-2. s. 59-68.

Bibtex

@article{fc215c3cb12f426fa75ebbc392a201cc,
title = "Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system",
abstract = "T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.",
keywords = "Adult, Aged, Astrocytes, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Central Nervous System, Cerebrospinal Fluid, Chemokine CXCL10, Chemokines, CXC, Female, Flow Cytometry, Humans, Male, Middle Aged, Multiple Sclerosis, Myelitis, Transverse, Optic Neuritis, Receptors, CXCR3, Receptors, Chemokine",
author = "S{\o}rensen, {Torben Lykke} and Corinna Trebst and Pia Kivis{\"a}kk and Klaege, {Karen L} and Amit Majmudar and Rivka Ravid and Hans Lassmann and Olsen, {David B} and Strieter, {Robert M} and Ransohoff, {Richard M} and Finn Sellebjerg",
year = "2002",
month = jun,
language = "English",
volume = "127",
pages = "59--68",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

AU - Sørensen, Torben Lykke

AU - Trebst, Corinna

AU - Kivisäkk, Pia

AU - Klaege, Karen L

AU - Majmudar, Amit

AU - Ravid, Rivka

AU - Lassmann, Hans

AU - Olsen, David B

AU - Strieter, Robert M

AU - Ransohoff, Richard M

AU - Sellebjerg, Finn

PY - 2002/6

Y1 - 2002/6

N2 - T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

AB - T-cell accumulation in the central nervous system (CNS) is considered crucial to the pathogenesis of multiple sclerosis (MS). We found that the majority of T cells within the cerebrospinal fluid (CSF) compartment expressed the CXC chemokine receptor 3 (CXCR), independent of CNS inflammation. Quantitative immunohistochemistry revealed continuous accumulation of CXCR3+ T cells during MS lesion formation. The expression of one CXCR3 ligand, interferon (IFN)-gamma-inducible protein of 10 kDa (IP-10)/CXC chemokine ligand (CXCL) 10 was elevated in MS CSF, spatially associated with demyelination in CNS tissue sections and correlated tightly with CXCR3 expression. These data suggest a critical role for CXCL10 and CXCR3 in the accumulation of T cells in the CNS of MS patients.

KW - Adult

KW - Aged

KW - Astrocytes

KW - CD4-Positive T-Lymphocytes

KW - CD8-Positive T-Lymphocytes

KW - Central Nervous System

KW - Cerebrospinal Fluid

KW - Chemokine CXCL10

KW - Chemokines, CXC

KW - Female

KW - Flow Cytometry

KW - Humans

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis

KW - Myelitis, Transverse

KW - Optic Neuritis

KW - Receptors, CXCR3

KW - Receptors, Chemokine

M3 - Journal article

C2 - 12044976

VL - 127

SP - 59

EP - 68

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

IS - 1-2

ER -

ID: 111410582