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Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. / Patsopoulos, Nikolaos A.; Baranzini, Sergio E.; Santaniello, Adam; Shoostari, Parisa; Cotsapas, Chris; Wong, Garrett; Beecham, Ashley H.; James, Tojo; Replogle, Joseph; Vlachos, Ioannis S.; McCabe, Cristin; Pers, Tune H.; Brandes, Aaron; White, Charles; Keenan, Brendan; Cimpean, Maria; Winn, Phoebe; Panteliadis, Ioannis Pavlos; Robbins, Allison; Andlauer, Till F.M.; Zarzycki, Onigiusz; Dubois, Bénédicte; Goris, An; Søndergaard, Helle Bach; Sellebjerg, Finn; Sorensen, Per Soelberg; Ullum, Henrik; Thørner, Lise Wegner; Saarela, Janna; Cournu-Rebeix, Isabelle; Damotte, Vincent; Fontaine, Bertrand; Guillot-Noel, Lena; Lathrop, Mark; Vukusic, Sandra; Berthele, Achim; Pongratz, Viola; Buck, Dorothea; Gasperi, Christiane; Graetz, Christiane; Grummel, Verena; Hemmer, Bernhard; Hoshi, Muni; Knier, Benjamin; Korn, Thomas; Lill, Christina M.; Luessi, Felix; Karpe, Fredrik; Lage, Kasper; Oturai, Annette; International Multiple Sclerosis Genetics Consortium; ANZgene, IIBDGC, WTCCC2.
I:
Science, Bind 365, Nr. 6460, eaav7188, 2019.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Patsopoulos, NA, Baranzini, SE, Santaniello, A, Shoostari, P, Cotsapas, C, Wong, G, Beecham, AH, James, T, Replogle, J, Vlachos, IS, McCabe, C
, Pers, TH, Brandes, A, White, C, Keenan, B, Cimpean, M, Winn, P, Panteliadis, IP, Robbins, A, Andlauer, TFM, Zarzycki, O, Dubois, B, Goris, A, Søndergaard, HB
, Sellebjerg, F, Sorensen, PS, Ullum, H, Thørner, LW, Saarela, J, Cournu-Rebeix, I, Damotte, V, Fontaine, B, Guillot-Noel, L, Lathrop, M, Vukusic, S, Berthele, A, Pongratz, V, Buck, D, Gasperi, C, Graetz, C, Grummel, V, Hemmer, B, Hoshi, M, Knier, B, Korn, T, Lill, CM, Luessi, F, Karpe, F, Lage, K, Oturai, A, International Multiple Sclerosis Genetics Consortium & ANZgene, IIBDGC, WTCCC2 2019, '
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility',
Science, bind 365, nr. 6460, eaav7188.
https://doi.org/10.1126/science.aav7188APA
Patsopoulos, N. A., Baranzini, S. E., Santaniello, A., Shoostari, P., Cotsapas, C., Wong, G., Beecham, A. H., James, T., Replogle, J., Vlachos, I. S., McCabe, C.
, Pers, T. H., Brandes, A., White, C., Keenan, B., Cimpean, M., Winn, P., Panteliadis, I. P., Robbins, A., ... ANZgene, IIBDGC, WTCCC2 (2019).
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.
Science,
365(6460), [eaav7188].
https://doi.org/10.1126/science.aav7188Vancouver
Patsopoulos NA, Baranzini SE, Santaniello A, Shoostari P, Cotsapas C, Wong G o.a.
Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility.
Science. 2019;365(6460). eaav7188.
https://doi.org/10.1126/science.aav7188Author
Patsopoulos, Nikolaos A. ; Baranzini, Sergio E. ; Santaniello, Adam ; Shoostari, Parisa ; Cotsapas, Chris ; Wong, Garrett ; Beecham, Ashley H. ; James, Tojo ; Replogle, Joseph ; Vlachos, Ioannis S. ; McCabe, Cristin ; Pers, Tune H. ; Brandes, Aaron ; White, Charles ; Keenan, Brendan ; Cimpean, Maria ; Winn, Phoebe ; Panteliadis, Ioannis Pavlos ; Robbins, Allison ; Andlauer, Till F.M. ; Zarzycki, Onigiusz ; Dubois, Bénédicte ; Goris, An ; Søndergaard, Helle Bach ; Sellebjerg, Finn ; Sorensen, Per Soelberg ; Ullum, Henrik ; Thørner, Lise Wegner ; Saarela, Janna ; Cournu-Rebeix, Isabelle ; Damotte, Vincent ; Fontaine, Bertrand ; Guillot-Noel, Lena ; Lathrop, Mark ; Vukusic, Sandra ; Berthele, Achim ; Pongratz, Viola ; Buck, Dorothea ; Gasperi, Christiane ; Graetz, Christiane ; Grummel, Verena ; Hemmer, Bernhard ; Hoshi, Muni ; Knier, Benjamin ; Korn, Thomas ; Lill, Christina M. ; Luessi, Felix ; Karpe, Fredrik ; Lage, Kasper ; Oturai, Annette ; International Multiple Sclerosis Genetics Consortium ; ANZgene, IIBDGC, WTCCC2. / Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility. I: Science. 2019 ; Bind 365, Nr. 6460.
Bibtex
@article{7bf232beac234bf798eaf1a4fdbfa3ed,
title = "Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility",
abstract = "We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular components of the immune system. Using expression profiles from purified human microglia, we observed enrichment for MS genes in these brain-resident immune cells, suggesting that these may have a role in targeting an autoimmune process to the central nervous system, although MS is most likely initially triggered by perturbation of peripheral immune responses.",
author = "Patsopoulos, {Nikolaos A.} and Baranzini, {Sergio E.} and Adam Santaniello and Parisa Shoostari and Chris Cotsapas and Garrett Wong and Beecham, {Ashley H.} and Tojo James and Joseph Replogle and Vlachos, {Ioannis S.} and Cristin McCabe and Pers, {Tune H.} and Aaron Brandes and Charles White and Brendan Keenan and Maria Cimpean and Phoebe Winn and Panteliadis, {Ioannis Pavlos} and Allison Robbins and Andlauer, {Till F.M.} and Onigiusz Zarzycki and B{\'e}n{\'e}dicte Dubois and An Goris and S{\o}ndergaard, {Helle Bach} and Finn Sellebjerg and Sorensen, {Per Soelberg} and Henrik Ullum and Th{\o}rner, {Lise Wegner} and Janna Saarela and Isabelle Cournu-Rebeix and Vincent Damotte and Bertrand Fontaine and Lena Guillot-Noel and Mark Lathrop and Sandra Vukusic and Achim Berthele and Viola Pongratz and Dorothea Buck and Christiane Gasperi and Christiane Graetz and Verena Grummel and Bernhard Hemmer and Muni Hoshi and Benjamin Knier and Thomas Korn and Lill, {Christina M.} and Felix Luessi and Fredrik Karpe and Kasper Lage and Annette Oturai and {International Multiple Sclerosis Genetics Consortium} and {ANZgene, IIBDGC, WTCCC2}",
year = "2019",
doi = "10.1126/science.aav7188",
language = "English",
volume = "365",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6460",
}
RIS
TY - JOUR
T1 - Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility
AU - Patsopoulos, Nikolaos A.
AU - Baranzini, Sergio E.
AU - Santaniello, Adam
AU - Shoostari, Parisa
AU - Cotsapas, Chris
AU - Wong, Garrett
AU - Beecham, Ashley H.
AU - James, Tojo
AU - Replogle, Joseph
AU - Vlachos, Ioannis S.
AU - McCabe, Cristin
AU - Pers, Tune H.
AU - Brandes, Aaron
AU - White, Charles
AU - Keenan, Brendan
AU - Cimpean, Maria
AU - Winn, Phoebe
AU - Panteliadis, Ioannis Pavlos
AU - Robbins, Allison
AU - Andlauer, Till F.M.
AU - Zarzycki, Onigiusz
AU - Dubois, Bénédicte
AU - Goris, An
AU - Søndergaard, Helle Bach
AU - Sellebjerg, Finn
AU - Sorensen, Per Soelberg
AU - Ullum, Henrik
AU - Thørner, Lise Wegner
AU - Saarela, Janna
AU - Cournu-Rebeix, Isabelle
AU - Damotte, Vincent
AU - Fontaine, Bertrand
AU - Guillot-Noel, Lena
AU - Lathrop, Mark
AU - Vukusic, Sandra
AU - Berthele, Achim
AU - Pongratz, Viola
AU - Buck, Dorothea
AU - Gasperi, Christiane
AU - Graetz, Christiane
AU - Grummel, Verena
AU - Hemmer, Bernhard
AU - Hoshi, Muni
AU - Knier, Benjamin
AU - Korn, Thomas
AU - Lill, Christina M.
AU - Luessi, Felix
AU - Karpe, Fredrik
AU - Lage, Kasper
AU - Oturai, Annette
AU - International Multiple Sclerosis Genetics Consortium
AU - ANZgene, IIBDGC, WTCCC2
PY - 2019
Y1 - 2019
N2 - We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular components of the immune system. Using expression profiles from purified human microglia, we observed enrichment for MS genes in these brain-resident immune cells, suggesting that these may have a role in targeting an autoimmune process to the central nervous system, although MS is most likely initially triggered by perturbation of peripheral immune responses.
AB - We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular components of the immune system. Using expression profiles from purified human microglia, we observed enrichment for MS genes in these brain-resident immune cells, suggesting that these may have a role in targeting an autoimmune process to the central nervous system, although MS is most likely initially triggered by perturbation of peripheral immune responses.
U2 - 10.1126/science.aav7188
DO - 10.1126/science.aav7188
M3 - Journal article
C2 - 31604244
AN - SCOPUS:85072692374
VL - 365
JO - Science
JF - Science
SN - 0036-8075
IS - 6460
M1 - eaav7188
ER -
