On the etiology of incident brain lacunes: longitudinal observations from the LADIS study

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Standard

On the etiology of incident brain lacunes: longitudinal observations from the LADIS study. / Gouw, A.A.; Flier, W.M. van der; Pantoni, L.; Inzitari, D.; Erkinjuntti, T.; Wahlund, L.O.; Waldemar, G.; Schmidt, R.; Fazekas, F.; Scheltens, P.; Barkhof, F.

I: Stroke, Bind 39, Nr. 11, 2008, s. 3083-3085.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Gouw, AA, Flier, WMVD, Pantoni, L, Inzitari, D, Erkinjuntti, T, Wahlund, LO, Waldemar, G, Schmidt, R, Fazekas, F, Scheltens, P & Barkhof, F 2008, 'On the etiology of incident brain lacunes: longitudinal observations from the LADIS study', Stroke, bind 39, nr. 11, s. 3083-3085.

APA

Gouw, A. A., Flier, W. M. V. D., Pantoni, L., Inzitari, D., Erkinjuntti, T., Wahlund, L. O., Waldemar, G., Schmidt, R., Fazekas, F., Scheltens, P., & Barkhof, F. (2008). On the etiology of incident brain lacunes: longitudinal observations from the LADIS study. Stroke, 39(11), 3083-3085.

Vancouver

Gouw AA, Flier WMVD, Pantoni L, Inzitari D, Erkinjuntti T, Wahlund LO o.a. On the etiology of incident brain lacunes: longitudinal observations from the LADIS study. Stroke. 2008;39(11):3083-3085.

Author

Gouw, A.A. ; Flier, W.M. van der ; Pantoni, L. ; Inzitari, D. ; Erkinjuntti, T. ; Wahlund, L.O. ; Waldemar, G. ; Schmidt, R. ; Fazekas, F. ; Scheltens, P. ; Barkhof, F. / On the etiology of incident brain lacunes: longitudinal observations from the LADIS study. I: Stroke. 2008 ; Bind 39, Nr. 11. s. 3083-3085.

Bibtex

@article{99fe6900987b11de8bc9000ea68e967b,
title = "On the etiology of incident brain lacunes: longitudinal observations from the LADIS study",
abstract = "BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period. METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors. RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes. CONCLUSIONS: Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region Udgivelsesdato: 2008/11",
author = "A.A. Gouw and Flier, {W.M. van der} and L. Pantoni and D. Inzitari and T. Erkinjuntti and L.O. Wahlund and G. Waldemar and R. Schmidt and F. Fazekas and P. Scheltens and F. Barkhof",
year = "2008",
language = "English",
volume = "39",
pages = "3083--3085",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams & Wilkins",
number = "11",

}

RIS

TY - JOUR

T1 - On the etiology of incident brain lacunes: longitudinal observations from the LADIS study

AU - Gouw, A.A.

AU - Flier, W.M. van der

AU - Pantoni, L.

AU - Inzitari, D.

AU - Erkinjuntti, T.

AU - Wahlund, L.O.

AU - Waldemar, G.

AU - Schmidt, R.

AU - Fazekas, F.

AU - Scheltens, P.

AU - Barkhof, F.

PY - 2008

Y1 - 2008

N2 - BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period. METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors. RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes. CONCLUSIONS: Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region Udgivelsesdato: 2008/11

AB - BACKGROUND AND PURPOSE: We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period. METHODS: Baseline and 3-year follow-up MRI were collected within the LADIS study (n=358). Incident lacunes were characterized with respect to brain region, their appearance within pre-existent white matter hyperintensities (WMH), surrounding WMH size, and risk factors. RESULTS: 106 incident lacunes were observed in 62 patients (58 subcortical white matter [WM], 35 basal ganglia, and 13 infratentorial). Incident subcortical WM lacunes occurred more often within preexisting WMH (P=0.01) and were mostly accompanied by new and expanded WMH (P<0.001), compared to incident basal ganglia and infratentorial lacunes. Risk factors for incident subcortical WM lacunes were history of hypertension and stroke, whereas atrial fibrillation predicted incident basal ganglia/infratentorial lacunes. CONCLUSIONS: Differences in relation to WMH and risk factor profiles may suggest that incident lacunes in the subcortical WM have a different pathogenesis than those in the basal ganglia and infratentorial region Udgivelsesdato: 2008/11

M3 - Journal article

VL - 39

SP - 3083

EP - 3085

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 11

ER -

ID: 14150626