Onset symptoms in paediatric multiple sclerosis
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Onset symptoms in paediatric multiple sclerosis. / Boesen, Magnus Spangsberg; Sellebjerg, Finn; Blinkenberg, Morten.
I: Danish Medical Journal, Bind 61, Nr. 4, A4800, 04.2014, s. 1-4.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Onset symptoms in paediatric multiple sclerosis
AU - Boesen, Magnus Spangsberg
AU - Sellebjerg, Finn
AU - Blinkenberg, Morten
PY - 2014/4
Y1 - 2014/4
N2 - INTRODUCTION: Paediatric multiple sclerosis (MS) carries a relatively higher mortality and morbidity than adult MS. Paediatric MS symptoms and paraclinical findings at the first demyelinating event have never before been characterised in a Danish setting. The aim of this study was to compare symptoms and paraclinical findings at the first demyelinating event in paediatric MS with those of an adult MS population.MATERIAL AND METHODS: A total of 18 subjects with onset of MS relapse before 16 years of age were retrospectively included in the study. Case records were reviewed for symptoms at disease onset, cerebrospinal fluid findings, magnetic resonance imaging (MRI) and evoked potentials at the first demyelinating event. These data were compared with similar nationwide data from adults in Denmark.RESULTS: The median age was 14 (range 10-15) years at the first demyelinating event and the mean time to MS diagnosis was 1.7 years. The majority of children had sensory symptoms (47%; 95% confidence interval (CI): 23-72%) or optic neuritis (35%; CI: 14-62%) as their presenting symptoms. These results did not differ from the findings in adult MS subjects. Pleocytosis was present in 93% (CI: 66-100%) of paediatric MS subjects, 77% (CI: 46-95%) had an elevated IgG index and 85% (CI: 55-98%) had oligoclonal bands in the cerebrospinal fluid. MRI showed characteristic white matter lesions in all children (CI: 80-100%).CONCLUSION: MS symptoms at the first demyelinating event and diagnostic delay in paediatric MS subjects do not differ significantly from those seen in an adult MS population.FUNDING: not relevant.TRIAL REGISTRATION: not relevant.
AB - INTRODUCTION: Paediatric multiple sclerosis (MS) carries a relatively higher mortality and morbidity than adult MS. Paediatric MS symptoms and paraclinical findings at the first demyelinating event have never before been characterised in a Danish setting. The aim of this study was to compare symptoms and paraclinical findings at the first demyelinating event in paediatric MS with those of an adult MS population.MATERIAL AND METHODS: A total of 18 subjects with onset of MS relapse before 16 years of age were retrospectively included in the study. Case records were reviewed for symptoms at disease onset, cerebrospinal fluid findings, magnetic resonance imaging (MRI) and evoked potentials at the first demyelinating event. These data were compared with similar nationwide data from adults in Denmark.RESULTS: The median age was 14 (range 10-15) years at the first demyelinating event and the mean time to MS diagnosis was 1.7 years. The majority of children had sensory symptoms (47%; 95% confidence interval (CI): 23-72%) or optic neuritis (35%; CI: 14-62%) as their presenting symptoms. These results did not differ from the findings in adult MS subjects. Pleocytosis was present in 93% (CI: 66-100%) of paediatric MS subjects, 77% (CI: 46-95%) had an elevated IgG index and 85% (CI: 55-98%) had oligoclonal bands in the cerebrospinal fluid. MRI showed characteristic white matter lesions in all children (CI: 80-100%).CONCLUSION: MS symptoms at the first demyelinating event and diagnostic delay in paediatric MS subjects do not differ significantly from those seen in an adult MS population.FUNDING: not relevant.TRIAL REGISTRATION: not relevant.
KW - Adolescent
KW - Age of Onset
KW - Child
KW - Evoked Potentials, Somatosensory
KW - Evoked Potentials, Visual
KW - Female
KW - Humans
KW - Leukocytosis
KW - Magnetic Resonance Imaging
KW - Male
KW - Multiple Sclerosis
KW - Retrospective Studies
M3 - Journal article
C2 - 24814585
VL - 61
SP - 1
EP - 4
JO - Danish Medical Journal
JF - Danish Medical Journal
SN - 2245-1919
IS - 4
M1 - A4800
ER -
ID: 138384725