Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise

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Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise. / Jensen, Camilla Steen; Simonsen, Anja Hviid; Siersma, Volkert; Beyer, Nina; Frederiksen, Kristian Steen; Gottrup, Hanne; Hoffman, Kristine; Høgh, Peter; Frikke-Schmidt, Ruth; Sobol, Nanna Aue; Waldemar, Gunhild; Wermuth, Lene; Hasselbalch, Steen Gregers.

I: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Bind 5, Nr. 1, 2019, s. 99-106.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jensen, CS, Simonsen, AH, Siersma, V, Beyer, N, Frederiksen, KS, Gottrup, H, Hoffman, K, Høgh, P, Frikke-Schmidt, R, Sobol, NA, Waldemar, G, Wermuth, L & Hasselbalch, SG 2019, 'Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise', Alzheimer's and Dementia: Translational Research and Clinical Interventions, bind 5, nr. 1, s. 99-106. https://doi.org/10.1016/j.trci.2019.02.007

APA

Jensen, C. S., Simonsen, A. H., Siersma, V., Beyer, N., Frederiksen, K. S., Gottrup, H., Hoffman, K., Høgh, P., Frikke-Schmidt, R., Sobol, N. A., Waldemar, G., Wermuth, L., & Hasselbalch, S. G. (2019). Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 5(1), 99-106. https://doi.org/10.1016/j.trci.2019.02.007

Vancouver

Jensen CS, Simonsen AH, Siersma V, Beyer N, Frederiksen KS, Gottrup H o.a. Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise. Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2019;5(1):99-106. https://doi.org/10.1016/j.trci.2019.02.007

Author

Jensen, Camilla Steen ; Simonsen, Anja Hviid ; Siersma, Volkert ; Beyer, Nina ; Frederiksen, Kristian Steen ; Gottrup, Hanne ; Hoffman, Kristine ; Høgh, Peter ; Frikke-Schmidt, Ruth ; Sobol, Nanna Aue ; Waldemar, Gunhild ; Wermuth, Lene ; Hasselbalch, Steen Gregers. / Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise. I: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2019 ; Bind 5, Nr. 1. s. 99-106.

Bibtex

@article{9862d35bb4d74cc084214cfce614fbd3,
title = "Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise",
abstract = "Introduction: Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in APOE ε4 carriers. Methods: In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype. Results: We found that patients who were APOE ε4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures. Discussion: This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD.",
keywords = "Alzheimer's disease, APOE, Exercise, Genetic, Intervention",
author = "Jensen, {Camilla Steen} and Simonsen, {Anja Hviid} and Volkert Siersma and Nina Beyer and Frederiksen, {Kristian Steen} and Hanne Gottrup and Kristine Hoffman and Peter H{\o}gh and Ruth Frikke-Schmidt and Sobol, {Nanna Aue} and Gunhild Waldemar and Lene Wermuth and Hasselbalch, {Steen Gregers}",
year = "2019",
doi = "10.1016/j.trci.2019.02.007",
language = "English",
volume = "5",
pages = "99--106",
journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",
issn = "2352-8737",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Patients with Alzheimer's disease who carry the APOE ε4 allele benefit more from physical exercise

AU - Jensen, Camilla Steen

AU - Simonsen, Anja Hviid

AU - Siersma, Volkert

AU - Beyer, Nina

AU - Frederiksen, Kristian Steen

AU - Gottrup, Hanne

AU - Hoffman, Kristine

AU - Høgh, Peter

AU - Frikke-Schmidt, Ruth

AU - Sobol, Nanna Aue

AU - Waldemar, Gunhild

AU - Wermuth, Lene

AU - Hasselbalch, Steen Gregers

PY - 2019

Y1 - 2019

N2 - Introduction: Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in APOE ε4 carriers. Methods: In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype. Results: We found that patients who were APOE ε4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures. Discussion: This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD.

AB - Introduction: Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in APOE ε4 carriers. Methods: In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype. Results: We found that patients who were APOE ε4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures. Discussion: This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD.

KW - Alzheimer's disease

KW - APOE

KW - Exercise

KW - Genetic

KW - Intervention

U2 - 10.1016/j.trci.2019.02.007

DO - 10.1016/j.trci.2019.02.007

M3 - Journal article

C2 - 31011620

AN - SCOPUS:85063894609

VL - 5

SP - 99

EP - 106

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

SN - 2352-8737

IS - 1

ER -

ID: 239157247