Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

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Standard

Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation. / Ammitzbøll, Cecilie; Börnsen, Lars; Petersen, Eva Rosa; Oturai, Annette Bang; Søndergaard, Helle Bach; Grandjean, Philippe; Sellebjerg, Finn.

I: Journal of Neuroimmunology, Bind 330, 2019, s. 90-95.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ammitzbøll, C, Börnsen, L, Petersen, ER, Oturai, AB, Søndergaard, HB, Grandjean, P & Sellebjerg, F 2019, 'Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation', Journal of Neuroimmunology, bind 330, s. 90-95. https://doi.org/10.1016/j.jneuroim.2019.03.002

APA

Ammitzbøll, C., Börnsen, L., Petersen, E. R., Oturai, A. B., Søndergaard, H. B., Grandjean, P., & Sellebjerg, F. (2019). Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation. Journal of Neuroimmunology, 330, 90-95. https://doi.org/10.1016/j.jneuroim.2019.03.002

Vancouver

Ammitzbøll C, Börnsen L, Petersen ER, Oturai AB, Søndergaard HB, Grandjean P o.a. Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation. Journal of Neuroimmunology. 2019;330:90-95. https://doi.org/10.1016/j.jneuroim.2019.03.002

Author

Ammitzbøll, Cecilie ; Börnsen, Lars ; Petersen, Eva Rosa ; Oturai, Annette Bang ; Søndergaard, Helle Bach ; Grandjean, Philippe ; Sellebjerg, Finn. / Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation. I: Journal of Neuroimmunology. 2019 ; Bind 330. s. 90-95.

Bibtex

@article{a60110a65e8645ef9aa7dfabbb3ca206,
title = "Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation",
abstract = "Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein–Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.",
author = "Cecilie Ammitzb{\o}ll and Lars B{\"o}rnsen and Petersen, {Eva Rosa} and Oturai, {Annette Bang} and S{\o}ndergaard, {Helle Bach} and Philippe Grandjean and Finn Sellebjerg",
year = "2019",
doi = "10.1016/j.jneuroim.2019.03.002",
language = "English",
volume = "330",
pages = "90--95",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

AU - Ammitzbøll, Cecilie

AU - Börnsen, Lars

AU - Petersen, Eva Rosa

AU - Oturai, Annette Bang

AU - Søndergaard, Helle Bach

AU - Grandjean, Philippe

AU - Sellebjerg, Finn

PY - 2019

Y1 - 2019

N2 - Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein–Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.

AB - Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein–Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.

U2 - 10.1016/j.jneuroim.2019.03.002

DO - 10.1016/j.jneuroim.2019.03.002

M3 - Journal article

C2 - 30852181

AN - SCOPUS:85062384582

VL - 330

SP - 90

EP - 95

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

SN - 0165-5728

ER -

ID: 241107276