TY - JOUR

T1 - Potential for prevention of dementia in Denmark

AU - Jørgensen, Kasper

AU - Nielsen, T. Rune

AU - Nielsen, Ann

AU - Waldemar, Gunhild

N1 - Funding Information: The Danish Dementia Research Centre is funded by the Danish Ministry of Health. Funding Information: The authors would also like to thank the DNHS for making the 2021 survey results publicly available. The DNHS was funded by the Capital Region, Zealand Region, South Denmark Region, Central Denmark Region, North Denmark Region, Ministry of Health, and National Institute of Public Health, University of Southern Denmark. Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

PY - 2023

Y1 - 2023

N2 - Introduction: According to previous estimates, 40% of dementia cases globally may be attributed to 12 potentially modifiable risk factors. Methods: We calculated national population attributable fractions (PAFs) for each risk factor and modeled the effects of proportional reductions in risk factor prevalence on dementia prevalence by calculating potential impact fractions (PIFs) for each factor. Results: The overall adjusted PAF for all risk factors was 35.2%. Physical inactivity, hearing loss, hypertension, and obesity accounted for 64% of the total prevention potential. The overall adjusted PIF was 4.1% at 10% risk factor prevalence reduction and 8.1% at 20% risk factor reduction. Discussion: Estimates of the potential for the prevention of dementia should be based on country-specific data on risk factor prevalence, as estimates based on global risk factor prevalence have limited relevance from a national perspective. Physical inactivity, hearing loss, hypertension, and obesity could be primary targets for prevention of dementia in Denmark. Highlights: Overall adjusted PAF for potentially modifiable dementia risk factors was 35%. Physical inactivity, hearing loss, hypertension, and obesity had the largest prevention potential. Estimates of prevention potential should be based on national risk factor prevalence.

AB - Introduction: According to previous estimates, 40% of dementia cases globally may be attributed to 12 potentially modifiable risk factors. Methods: We calculated national population attributable fractions (PAFs) for each risk factor and modeled the effects of proportional reductions in risk factor prevalence on dementia prevalence by calculating potential impact fractions (PIFs) for each factor. Results: The overall adjusted PAF for all risk factors was 35.2%. Physical inactivity, hearing loss, hypertension, and obesity accounted for 64% of the total prevention potential. The overall adjusted PIF was 4.1% at 10% risk factor prevalence reduction and 8.1% at 20% risk factor reduction. Discussion: Estimates of the potential for the prevention of dementia should be based on country-specific data on risk factor prevalence, as estimates based on global risk factor prevalence have limited relevance from a national perspective. Physical inactivity, hearing loss, hypertension, and obesity could be primary targets for prevention of dementia in Denmark. Highlights: Overall adjusted PAF for potentially modifiable dementia risk factors was 35%. Physical inactivity, hearing loss, hypertension, and obesity had the largest prevention potential. Estimates of prevention potential should be based on national risk factor prevalence.

KW - dementia

KW - epidemiology

KW - population attributable fraction

KW - prevention

KW - risk factors

U2 - 10.1002/alz.13030

DO - 10.1002/alz.13030

M3 - Journal article

C2 - 36933232

AN - SCOPUS:85150780458

VL - 19

SP - 4590

EP - 4598

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

SN - 1552-5260

IS - 10

ER -