TY - JOUR

T1 - Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study

AU - Ropele, Stefan

AU - Seewann, Alexandra

AU - Gouw, Alida A

AU - van der Flier, Wiesje M

AU - Schmidt, Reinhold

AU - Pantoni, Leonardo

AU - Inzitari, Domenico

AU - Erkinjuntti, Timo

AU - Scheltens, Philip

AU - Wahlund, Lars O

AU - Waldemar, Gunhild

AU - Chabriat, Hugues

AU - Ferro, José

AU - Hennerici, Michael

AU - O'Brien, John

AU - Wallin, Anders

AU - Langhorne, Peter

AU - Visser, Marieke C

AU - Barkhof, Frederik

AU - Fazekas, Franz

AU - LADIS study group

N1 - Keywords: Aged; Aged, 80 and over; Analysis of Variance; Diffusion Magnetic Resonance Imaging; Female; Humans; Imaging, Three-Dimensional; Leukoaraiosis; Magnetic Resonance Imaging; Male; Severity of Illness Index

PY - 2009

Y1 - 2009

N2 - PURPOSE: To explore the value of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) for the improved detection and quantification of cerebral tissue changes associated with ageing and white matter hyperintensities (WMH). MATERIALS AND METHODS: DWI (n = 340) and MTI (n = 177) were performed in nine centers of the multinational Leukoaraiosis And DISability (LADIS) study investigating the impact of WMH on 65- to 85-year-old individuals without prior disability. We assessed the apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) of normal appearing brain tissue (NABT) and within WMH and related them to subjects' age and WHM severity according to the Fazekas score. RESULTS: ADC and MTR values showed a significant inter-site variation, which was stronger for the MTR. After z-transformation multiple regression analysis revealed WMH severity and age as significant predictors of global ADC and MTR changes. Only lesional ADC, but not MTR was related to WMH severity. CONCLUSION: ADC and MTR are both sensitive for age and WMH related changes in NABT. The ADC is more sensitive for tissue changes within WMH and appears to be more robust for multicenter settings.

AB - PURPOSE: To explore the value of diffusion-weighted imaging (DWI) and magnetization transfer imaging (MTI) for the improved detection and quantification of cerebral tissue changes associated with ageing and white matter hyperintensities (WMH). MATERIALS AND METHODS: DWI (n = 340) and MTI (n = 177) were performed in nine centers of the multinational Leukoaraiosis And DISability (LADIS) study investigating the impact of WMH on 65- to 85-year-old individuals without prior disability. We assessed the apparent diffusion coefficient (ADC) and magnetization transfer ratio (MTR) of normal appearing brain tissue (NABT) and within WMH and related them to subjects' age and WHM severity according to the Fazekas score. RESULTS: ADC and MTR values showed a significant inter-site variation, which was stronger for the MTR. After z-transformation multiple regression analysis revealed WMH severity and age as significant predictors of global ADC and MTR changes. Only lesional ADC, but not MTR was related to WMH severity. CONCLUSION: ADC and MTR are both sensitive for age and WMH related changes in NABT. The ADC is more sensitive for tissue changes within WMH and appears to be more robust for multicenter settings.

U2 - 10.1002/jmri.21580

DO - 10.1002/jmri.21580

M3 - Journal article

C2 - 19161174

VL - 29

SP - 268

EP - 274

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 2

ER -