Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia. / Simonsen, Anja Hviid; Herukka, Sanna-Kaisa; Andreasen, Niels; Baldeiras, Ines; Bjerke, Maria; Blennow, Kaj; Engelborghs, Sebastiaan; Frisoni, Giovanni B; Gabryelewicz, Tomasz; Galluzzi, Samantha; Handels, Ron; Kramberger, Milica G; Kulczyńska, Agnieszka; Molinuevo, Jose Luis; Mroczko, Barbara; Nordberg, Agneta; Oliveira, Catarina Resende; Otto, Markus; Rinne, Juha O; Rot, Uroš; Saka, Esen; Soininen, Hilkka; Struyfs, Hanne; Suardi, Silvia; Visser, Pieter Jelle; Winblad, Bengt; Zetterberg, Henrik; Waldemar, Gunhild.

I: Alzheimer's & Dementia, Bind 13, Nr. 3, 03.2017, s. 274-284.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Simonsen, AH, Herukka, S-K, Andreasen, N, Baldeiras, I, Bjerke, M, Blennow, K, Engelborghs, S, Frisoni, GB, Gabryelewicz, T, Galluzzi, S, Handels, R, Kramberger, MG, Kulczyńska, A, Molinuevo, JL, Mroczko, B, Nordberg, A, Oliveira, CR, Otto, M, Rinne, JO, Rot, U, Saka, E, Soininen, H, Struyfs, H, Suardi, S, Visser, PJ, Winblad, B, Zetterberg, H & Waldemar, G 2017, 'Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia', Alzheimer's & Dementia, bind 13, nr. 3, s. 274-284. https://doi.org/10.1016/j.jalz.2016.09.008

APA

Simonsen, A. H., Herukka, S-K., Andreasen, N., Baldeiras, I., Bjerke, M., Blennow, K., Engelborghs, S., Frisoni, G. B., Gabryelewicz, T., Galluzzi, S., Handels, R., Kramberger, M. G., Kulczyńska, A., Molinuevo, J. L., Mroczko, B., Nordberg, A., Oliveira, C. R., Otto, M., Rinne, J. O., ... Waldemar, G. (2017). Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia. Alzheimer's & Dementia, 13(3), 274-284. https://doi.org/10.1016/j.jalz.2016.09.008

Vancouver

Simonsen AH, Herukka S-K, Andreasen N, Baldeiras I, Bjerke M, Blennow K o.a. Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia. Alzheimer's & Dementia. 2017 mar.;13(3):274-284. https://doi.org/10.1016/j.jalz.2016.09.008

Author

Simonsen, Anja Hviid ; Herukka, Sanna-Kaisa ; Andreasen, Niels ; Baldeiras, Ines ; Bjerke, Maria ; Blennow, Kaj ; Engelborghs, Sebastiaan ; Frisoni, Giovanni B ; Gabryelewicz, Tomasz ; Galluzzi, Samantha ; Handels, Ron ; Kramberger, Milica G ; Kulczyńska, Agnieszka ; Molinuevo, Jose Luis ; Mroczko, Barbara ; Nordberg, Agneta ; Oliveira, Catarina Resende ; Otto, Markus ; Rinne, Juha O ; Rot, Uroš ; Saka, Esen ; Soininen, Hilkka ; Struyfs, Hanne ; Suardi, Silvia ; Visser, Pieter Jelle ; Winblad, Bengt ; Zetterberg, Henrik ; Waldemar, Gunhild. / Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia. I: Alzheimer's & Dementia. 2017 ; Bind 13, Nr. 3. s. 274-284.

Bibtex

@article{daabec5f251142429ba6242a8898b8a2,

title = "Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia",

abstract = "This article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebrospinal fluid (CSF) amyloid-β1-42, tau, and phosphorylated tau in the diagnostic evaluation of patients with dementia. The recommendations were developed by a multidisciplinary working group based on the available evidence and consensus from focused discussions for (i) identification of Alzheimer's disease (AD) as the cause of dementia, (ii) prediction of rate of decline, (iii) cost-effectiveness, and (iv) interpretation of results. The working group found sufficient evidence to support a recommendation to use CSF AD biomarkers as a supplement to clinical evaluation, particularly in uncertain and atypical cases, to identify or exclude AD as the cause of dementia. Because of insufficient evidence, it was uncertain whether CSF AD biomarkers outperform imaging biomarkers. Operational recommendations for the interpretation of ambiguous CSF biomarker results were also provided.",

keywords = "Alzheimer Disease/cerebrospinal fluid, Amyloid beta-Peptides/cerebrospinal fluid, Biomarkers/cerebrospinal fluid, Databases, Bibliographic/statistics & numerical data, Humans, Peptide Fragments/cerebrospinal fluid, tau Proteins/cerebrospinal fluid",

author = "Simonsen, {Anja Hviid} and Sanna-Kaisa Herukka and Niels Andreasen and Ines Baldeiras and Maria Bjerke and Kaj Blennow and Sebastiaan Engelborghs and Frisoni, {Giovanni B} and Tomasz Gabryelewicz and Samantha Galluzzi and Ron Handels and Kramberger, {Milica G} and Agnieszka Kulczy{\'n}ska and Molinuevo, {Jose Luis} and Barbara Mroczko and Agneta Nordberg and Oliveira, {Catarina Resende} and Markus Otto and Rinne, {Juha O} and Uro{\v s} Rot and Esen Saka and Hilkka Soininen and Hanne Struyfs and Silvia Suardi and Visser, {Pieter Jelle} and Bengt Winblad and Henrik Zetterberg and Gunhild Waldemar",

year = "2017",

month = mar,

doi = "10.1016/j.jalz.2016.09.008",

language = "English",

volume = "13",

pages = "274--284",

journal = "Alzheimer's & Dementia",

issn = "1552-5260",

publisher = "Elsevier",

number = "3",

}

RIS

TY - JOUR

T1 - Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia

AU - Simonsen, Anja Hviid

AU - Herukka, Sanna-Kaisa

AU - Andreasen, Niels

AU - Baldeiras, Ines

AU - Bjerke, Maria

AU - Blennow, Kaj

AU - Engelborghs, Sebastiaan

AU - Frisoni, Giovanni B

AU - Gabryelewicz, Tomasz

AU - Galluzzi, Samantha

AU - Handels, Ron

AU - Kramberger, Milica G

AU - Kulczyńska, Agnieszka

AU - Molinuevo, Jose Luis

AU - Mroczko, Barbara

AU - Nordberg, Agneta

AU - Oliveira, Catarina Resende

AU - Otto, Markus

AU - Rinne, Juha O

AU - Rot, Uroš

AU - Saka, Esen

AU - Soininen, Hilkka

AU - Struyfs, Hanne

AU - Suardi, Silvia

AU - Visser, Pieter Jelle

AU - Winblad, Bengt

AU - Zetterberg, Henrik

AU - Waldemar, Gunhild

PY - 2017/3

Y1 - 2017/3

N2 - This article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebrospinal fluid (CSF) amyloid-β1-42, tau, and phosphorylated tau in the diagnostic evaluation of patients with dementia. The recommendations were developed by a multidisciplinary working group based on the available evidence and consensus from focused discussions for (i) identification of Alzheimer's disease (AD) as the cause of dementia, (ii) prediction of rate of decline, (iii) cost-effectiveness, and (iv) interpretation of results. The working group found sufficient evidence to support a recommendation to use CSF AD biomarkers as a supplement to clinical evaluation, particularly in uncertain and atypical cases, to identify or exclude AD as the cause of dementia. Because of insufficient evidence, it was uncertain whether CSF AD biomarkers outperform imaging biomarkers. Operational recommendations for the interpretation of ambiguous CSF biomarker results were also provided.

AB - This article presents recommendations, based on the Grading of Recommendations, Assessment, Development, and Evaluation method, for the clinical application of cerebrospinal fluid (CSF) amyloid-β1-42, tau, and phosphorylated tau in the diagnostic evaluation of patients with dementia. The recommendations were developed by a multidisciplinary working group based on the available evidence and consensus from focused discussions for (i) identification of Alzheimer's disease (AD) as the cause of dementia, (ii) prediction of rate of decline, (iii) cost-effectiveness, and (iv) interpretation of results. The working group found sufficient evidence to support a recommendation to use CSF AD biomarkers as a supplement to clinical evaluation, particularly in uncertain and atypical cases, to identify or exclude AD as the cause of dementia. Because of insufficient evidence, it was uncertain whether CSF AD biomarkers outperform imaging biomarkers. Operational recommendations for the interpretation of ambiguous CSF biomarker results were also provided.

KW - Alzheimer Disease/cerebrospinal fluid

KW - Amyloid beta-Peptides/cerebrospinal fluid

KW - Biomarkers/cerebrospinal fluid

KW - Databases, Bibliographic/statistics & numerical data

KW - Humans

KW - Peptide Fragments/cerebrospinal fluid

KW - tau Proteins/cerebrospinal fluid

U2 - 10.1016/j.jalz.2016.09.008

DO - 10.1016/j.jalz.2016.09.008

M3 - Review

C2 - 28341065

VL - 13

SP - 274

EP - 284

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

SN - 1552-5260

IS - 3

ER -

ID: 195158536

Institut for Klinisk Medicin