Reduced CSF CART in dementia with Lewy bodies

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Reduced CSF CART in dementia with Lewy bodies. / Schultz, Kristofer; Wiehager, Sara; Nilsson, Karin; Nielsen, Jørgen E; Lindquist, Suzanne G; Hjermind, Lena E; Andersen, Birgitte B; Wallin, Anders; Nilsson, Christer; Petersén, Asa.

I: Neuroscience Letters, Bind 453, Nr. 2, 2009, s. 104-6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Schultz, K, Wiehager, S, Nilsson, K, Nielsen, JE, Lindquist, SG, Hjermind, LE, Andersen, BB, Wallin, A, Nilsson, C & Petersén, A 2009, 'Reduced CSF CART in dementia with Lewy bodies', Neuroscience Letters, bind 453, nr. 2, s. 104-6. https://doi.org/10.1016/j.neulet.2009.02.008

APA

Schultz, K., Wiehager, S., Nilsson, K., Nielsen, J. E., Lindquist, S. G., Hjermind, L. E., Andersen, B. B., Wallin, A., Nilsson, C., & Petersén, A. (2009). Reduced CSF CART in dementia with Lewy bodies. Neuroscience Letters, 453(2), 104-6. https://doi.org/10.1016/j.neulet.2009.02.008

Vancouver

Schultz K, Wiehager S, Nilsson K, Nielsen JE, Lindquist SG, Hjermind LE o.a. Reduced CSF CART in dementia with Lewy bodies. Neuroscience Letters. 2009;453(2):104-6. https://doi.org/10.1016/j.neulet.2009.02.008

Author

Schultz, Kristofer ; Wiehager, Sara ; Nilsson, Karin ; Nielsen, Jørgen E ; Lindquist, Suzanne G ; Hjermind, Lena E ; Andersen, Birgitte B ; Wallin, Anders ; Nilsson, Christer ; Petersén, Asa. / Reduced CSF CART in dementia with Lewy bodies. I: Neuroscience Letters. 2009 ; Bind 453, Nr. 2. s. 104-6.

Bibtex

@article{7bd028a068ab11df928f000ea68e967b,
title = "Reduced CSF CART in dementia with Lewy bodies",
abstract = "Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.",
author = "Kristofer Schultz and Sara Wiehager and Karin Nilsson and Nielsen, {J{\o}rgen E} and Lindquist, {Suzanne G} and Hjermind, {Lena E} and Andersen, {Birgitte B} and Anders Wallin and Christer Nilsson and Asa Peters{\'e}n",
note = "Keywords: Aged; Alzheimer Disease; Amyloid beta-Protein; Analysis of Variance; Female; Humans; Lewy Body Disease; Male; Nerve Tissue Proteins; Peptide Fragments; Radioimmunoassay; tau Proteins",
year = "2009",
doi = "10.1016/j.neulet.2009.02.008",
language = "English",
volume = "453",
pages = "104--6",
journal = "Neuroscience letters. Supplement",
issn = "0167-6253",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Reduced CSF CART in dementia with Lewy bodies

AU - Schultz, Kristofer

AU - Wiehager, Sara

AU - Nilsson, Karin

AU - Nielsen, Jørgen E

AU - Lindquist, Suzanne G

AU - Hjermind, Lena E

AU - Andersen, Birgitte B

AU - Wallin, Anders

AU - Nilsson, Christer

AU - Petersén, Asa

N1 - Keywords: Aged; Alzheimer Disease; Amyloid beta-Protein; Analysis of Variance; Female; Humans; Lewy Body Disease; Male; Nerve Tissue Proteins; Peptide Fragments; Radioimmunoassay; tau Proteins

PY - 2009

Y1 - 2009

N2 - Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.

AB - Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomarkers are yet available for the diagnosis of DLB. In a recent MRI study, DLB patients displayed hypothalamic atrophy whereas this region was not affected in AD patients. Cocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed selectively in neurons in the hypothalamus. Here, we found that CSF CART levels were significantly reduced by 30% in DLB patients (n = 12) compared to controls (n = 12) as well as to AD patients (n = 14) using radioimmunoassay. Our preliminary results suggest that reduced CSF CART is a sign of hypothalamic dysfunction in DLB and that it may serve as a biomarker for this patient group.

U2 - 10.1016/j.neulet.2009.02.008

DO - 10.1016/j.neulet.2009.02.008

M3 - Journal article

C2 - 19356602

VL - 453

SP - 104

EP - 106

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

SN - 0167-6253

IS - 2

ER -

ID: 19978200