Rhabdomyolysis following interferon-beta treatment in a patient with multiple sclerosis: A case report
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Rhabdomyolysis following interferon-beta treatment in a patient with multiple sclerosis : A case report. / Dalbjerg, Sara Maria; Tsakiri, Anna; Fredriksen, Jette Lautrup.
I: Multiple Sclerosis and Related Disorders, Bind 8, 07.2016, s. 93-95.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Rhabdomyolysis following interferon-beta treatment in a patient with multiple sclerosis
T2 - A case report
AU - Dalbjerg, Sara Maria
AU - Tsakiri, Anna
AU - Fredriksen, Jette Lautrup
PY - 2016/7
Y1 - 2016/7
N2 - Background Multiple sclerosis is an inflammatory disease of the central nervous system for which there is currently no cure. Interferon-beta-1-alpha is worldwide one of the most widely used treatments in multiple sclerosis. To our knowledge there is one previous reported case of rhabdomyolysis associated with Interferon-beta treatment. Case presentation We describe a 30 year old man with relapsing remitting multiple sclerosis who developed rhabdomyolysis and increased creatine kinase following Interferon-beta-1-alpha therapy. After the medication was discontinued, the patient rapidly improved. Conclusion Clinicians should be aware of the possibility of rhabdomyolysis occurring during Interferon-beta-1-alpha therapy. In cases where patients complain of severe myalgia, and in particular if weakness is reported, creatine kinase activity should be measured to prevent irreversible rhabdomyolysis during Interferon-beta-1-alpha therapy in patients with multiple sclerosis.
AB - Background Multiple sclerosis is an inflammatory disease of the central nervous system for which there is currently no cure. Interferon-beta-1-alpha is worldwide one of the most widely used treatments in multiple sclerosis. To our knowledge there is one previous reported case of rhabdomyolysis associated with Interferon-beta treatment. Case presentation We describe a 30 year old man with relapsing remitting multiple sclerosis who developed rhabdomyolysis and increased creatine kinase following Interferon-beta-1-alpha therapy. After the medication was discontinued, the patient rapidly improved. Conclusion Clinicians should be aware of the possibility of rhabdomyolysis occurring during Interferon-beta-1-alpha therapy. In cases where patients complain of severe myalgia, and in particular if weakness is reported, creatine kinase activity should be measured to prevent irreversible rhabdomyolysis during Interferon-beta-1-alpha therapy in patients with multiple sclerosis.
KW - Adverse effect
KW - Interferon-beta treatment
KW - Multiple sclerosis
KW - Quality of life
KW - Rhabdomyolysis
U2 - 10.1016/j.msard.2016.05.005
DO - 10.1016/j.msard.2016.05.005
M3 - Journal article
C2 - 27456881
AN - SCOPUS:84970005869
VL - 8
SP - 93
EP - 95
JO - Multiple Sclerosis and Related Disorders
JF - Multiple Sclerosis and Related Disorders
SN - 2211-0348
ER -
ID: 179222638