Segmentation of age-related white matter changes in a clinical multi-center study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Segmentation of age-related white matter changes in a clinical multi-center study. / Dyrby, Tim B; Rostrup, Egill; Baaré, William F C; van Straaten, Elisabeth C W; Barkhof, Frederik; Vrenken, Hugo; Ropele, Stefan; Schmidt, Reinhold; Erkinjuntti, Timo; Wahlund, Lars-Olof; Pantoni, Leonardo; Inzitari, Domenico; Paulson, Olaf B; Hansen, Lars Kai; Waldemar, Gunhild; LADIS study group.
I: NeuroImage, Bind 41, Nr. 2, 2008, s. 335-345.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Segmentation of age-related white matter changes in a clinical multi-center study
AU - Dyrby, Tim B
AU - Rostrup, Egill
AU - Baaré, William F C
AU - van Straaten, Elisabeth C W
AU - Barkhof, Frederik
AU - Vrenken, Hugo
AU - Ropele, Stefan
AU - Schmidt, Reinhold
AU - Erkinjuntti, Timo
AU - Wahlund, Lars-Olof
AU - Pantoni, Leonardo
AU - Inzitari, Domenico
AU - Paulson, Olaf B
AU - Hansen, Lars Kai
AU - Waldemar, Gunhild
AU - LADIS study group
PY - 2008
Y1 - 2008
N2 - Age-related white matter changes (WMC) are thought to be a marker of vascular pathology, and have been associated with motor and cognitive deficits. In the present study, an optimized artificial neural network was used as an automatic segmentation method to produce probabilistic maps of WMC in a clinical multi-center study. The neural network uses information from T1- and T2-weighted and fluid attenuation inversion recovery (FLAIR) magnetic resonance (MR) scans, neighboring voxels and spatial location. Generalizability of the neural network was optimized by including the Optimal Brain Damage (OBD) pruning method in the training stage. Six optimized neural networks were produced to investigate the impact of different input information on WMC segmentation. The automatic segmentation method was applied to MR scans of 362 non-demented elderly subjects from 11 centers in the European multi-center study Leukoaraiosis And Disability (LADIS). Semi-manually delineated WMC were used for validating the segmentation produced by the neural networks. The neural network segmentation demonstrated high consistency between subjects and centers, making it a promising technique for large studies. For WMC volumes less than 10 ml, an increasing discrepancy between semi-manual and neural network segmentation was observed using the similarity index (SI) measure. The use of all three image modalities significantly improved cross-center generalizability compared to neural networks using the FLAIR image only. Expert knowledge not available to the neural networks was a minor source of discrepancy, while variation in MR scan quality constituted the largest source of error.
AB - Age-related white matter changes (WMC) are thought to be a marker of vascular pathology, and have been associated with motor and cognitive deficits. In the present study, an optimized artificial neural network was used as an automatic segmentation method to produce probabilistic maps of WMC in a clinical multi-center study. The neural network uses information from T1- and T2-weighted and fluid attenuation inversion recovery (FLAIR) magnetic resonance (MR) scans, neighboring voxels and spatial location. Generalizability of the neural network was optimized by including the Optimal Brain Damage (OBD) pruning method in the training stage. Six optimized neural networks were produced to investigate the impact of different input information on WMC segmentation. The automatic segmentation method was applied to MR scans of 362 non-demented elderly subjects from 11 centers in the European multi-center study Leukoaraiosis And Disability (LADIS). Semi-manually delineated WMC were used for validating the segmentation produced by the neural networks. The neural network segmentation demonstrated high consistency between subjects and centers, making it a promising technique for large studies. For WMC volumes less than 10 ml, an increasing discrepancy between semi-manual and neural network segmentation was observed using the similarity index (SI) measure. The use of all three image modalities significantly improved cross-center generalizability compared to neural networks using the FLAIR image only. Expert knowledge not available to the neural networks was a minor source of discrepancy, while variation in MR scan quality constituted the largest source of error.
KW - Aged
KW - Aged, 80 and over
KW - Aging
KW - Brain
KW - Humans
KW - Image Interpretation, Computer-Assisted
KW - Magnetic Resonance Imaging
KW - Neural Networks (Computer)
U2 - 10.1016/j.neuroimage.2008.02.024
DO - 10.1016/j.neuroimage.2008.02.024
M3 - Journal article
C2 - 18394928
VL - 41
SP - 335
EP - 345
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 2
ER -
ID: 10949735