Social Cognition, Executive Functions and Self-Report of Psychological Distress in Huntington's Disease
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Social Cognition, Executive Functions and Self-Report of Psychological Distress in Huntington's Disease. / Larsen, Ida Unmack; Vinther-Jensen, Tua; Nielsen, Jørgen Erik; Gade, Anders; Vogel, Asmus.
I: PLoS Currents, Bind 8, 28.12.2016, s. 1-20.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Social Cognition, Executive Functions and Self-Report of Psychological Distress in Huntington's Disease
AU - Larsen, Ida Unmack
AU - Vinther-Jensen, Tua
AU - Nielsen, Jørgen Erik
AU - Gade, Anders
AU - Vogel, Asmus
PY - 2016/12/28
Y1 - 2016/12/28
N2 - OBJECTIVE: Huntington's disease (HD) is characterized by motor symptoms, psychiatric symptoms and cognitive impairment in, inter alia, executive functions and social cognition. The aim of this study was to investigate the relationship between subjective feeling of psychological distress using a self-report questionnaire and performances on tests of executive functions and social cognition in a large consecutive cohort of HD patients.METHOD: 50 manifest HD patients were tested in social cognition and executive functions and each answered a self-report questionnaire about current status of perceived psychological distress (the Symptom Checklist-90-Revised (SCL-90-R)). Correlation analyses of test performance and SCL-90-R scores were made as well as stepwise linear regression analyses with the SCL-90-R GSI score and test performances as dependent variables.RESULTS: We found that less psychological distress was significantly associated with worse performances on social cognitive tests (mean absolute correlation .34) and that there were no significant correlations between perceived psychological distress and performance on tests of executive functions. The correlations between perceived psychological distress and performance on social cognitive tests remained significant after controlling for age, Unified Huntington's Disease Rating Scale-99 total motor score and performance on tests of executive functions.CONCLUSIONS: Based on previous findings that insight and apathy are closely connected and may be mediated by overlapping neuroanatomical networks involving the prefrontal cortex and frontostriatal circuits, we speculate that apathy/and or impaired insight may offer an explanation for the correlation between self-report of psychological distress and performance on social cognitive tests in this study.
AB - OBJECTIVE: Huntington's disease (HD) is characterized by motor symptoms, psychiatric symptoms and cognitive impairment in, inter alia, executive functions and social cognition. The aim of this study was to investigate the relationship between subjective feeling of psychological distress using a self-report questionnaire and performances on tests of executive functions and social cognition in a large consecutive cohort of HD patients.METHOD: 50 manifest HD patients were tested in social cognition and executive functions and each answered a self-report questionnaire about current status of perceived psychological distress (the Symptom Checklist-90-Revised (SCL-90-R)). Correlation analyses of test performance and SCL-90-R scores were made as well as stepwise linear regression analyses with the SCL-90-R GSI score and test performances as dependent variables.RESULTS: We found that less psychological distress was significantly associated with worse performances on social cognitive tests (mean absolute correlation .34) and that there were no significant correlations between perceived psychological distress and performance on tests of executive functions. The correlations between perceived psychological distress and performance on social cognitive tests remained significant after controlling for age, Unified Huntington's Disease Rating Scale-99 total motor score and performance on tests of executive functions.CONCLUSIONS: Based on previous findings that insight and apathy are closely connected and may be mediated by overlapping neuroanatomical networks involving the prefrontal cortex and frontostriatal circuits, we speculate that apathy/and or impaired insight may offer an explanation for the correlation between self-report of psychological distress and performance on social cognitive tests in this study.
KW - Journal Article
U2 - 10.1371/currents.hd.bba3a680813122013e6d3e8a144c1da8
DO - 10.1371/currents.hd.bba3a680813122013e6d3e8a144c1da8
M3 - Journal article
C2 - 28154786
VL - 8
SP - 1
EP - 20
JO - P L o S Currents
JF - P L o S Currents
SN - 2157-3999
ER -
ID: 173671828