T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

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Standard

T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis. / Hedegaard, Chris J; Krakauer, Martin; Bendtzen, Klaus; Lund, Henrik; Sellebjerg, Finn; Nielsen, Claus H.

I: Immunology, Bind 125, Nr. 2, 01.10.2008, s. 161-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hedegaard, CJ, Krakauer, M, Bendtzen, K, Lund, H, Sellebjerg, F & Nielsen, CH 2008, 'T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis', Immunology, bind 125, nr. 2, s. 161-9. https://doi.org/10.1111/j.1365-2567.2008.02837.x, https://doi.org/10.1111/j.1365-2567.2008.02837.x

APA

Hedegaard, C. J., Krakauer, M., Bendtzen, K., Lund, H., Sellebjerg, F., & Nielsen, C. H. (2008). T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis. Immunology, 125(2), 161-9. https://doi.org/10.1111/j.1365-2567.2008.02837.x, https://doi.org/10.1111/j.1365-2567.2008.02837.x

Vancouver

Hedegaard CJ, Krakauer M, Bendtzen K, Lund H, Sellebjerg F, Nielsen CH. T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis. Immunology. 2008 okt. 1;125(2):161-9. https://doi.org/10.1111/j.1365-2567.2008.02837.x, https://doi.org/10.1111/j.1365-2567.2008.02837.x

Author

Hedegaard, Chris J ; Krakauer, Martin ; Bendtzen, Klaus ; Lund, Henrik ; Sellebjerg, Finn ; Nielsen, Claus H. / T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis. I: Immunology. 2008 ; Bind 125, Nr. 2. s. 161-9.

Bibtex

@article{8cb3dfd0f37311ddbf70000ea68e967b,
title = "T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis",
abstract = "Autoreactive T cells are thought to play an essential role in the pathogenesis of multiple sclerosis (MS). We examined the stimulatory effect of human myelin basic protein (MBP) on mononuclear cell (MNC) cultures from 22 patients with MS and 22 sex-matched and age-matched healthy individuals, and related the patient responses to disease activity, as indicated by magnetic resonance imaging. The MBP induced a dose-dependent release of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) by patient-derived MNCs. The patients' cells produced higher amounts of IFN-gamma and TNF-alpha, and lower amounts of IL-10, than cells from healthy controls (P",
author = "Hedegaard, {Chris J} and Martin Krakauer and Klaus Bendtzen and Henrik Lund and Finn Sellebjerg and Nielsen, {Claus H}",
year = "2008",
month = oct,
day = "1",
doi = "10.1111/j.1365-2567.2008.02837.x",
language = "English",
volume = "125",
pages = "161--9",
journal = "Immunology",
issn = "0019-2805",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis

AU - Hedegaard, Chris J

AU - Krakauer, Martin

AU - Bendtzen, Klaus

AU - Lund, Henrik

AU - Sellebjerg, Finn

AU - Nielsen, Claus H

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Autoreactive T cells are thought to play an essential role in the pathogenesis of multiple sclerosis (MS). We examined the stimulatory effect of human myelin basic protein (MBP) on mononuclear cell (MNC) cultures from 22 patients with MS and 22 sex-matched and age-matched healthy individuals, and related the patient responses to disease activity, as indicated by magnetic resonance imaging. The MBP induced a dose-dependent release of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) by patient-derived MNCs. The patients' cells produced higher amounts of IFN-gamma and TNF-alpha, and lower amounts of IL-10, than cells from healthy controls (P

AB - Autoreactive T cells are thought to play an essential role in the pathogenesis of multiple sclerosis (MS). We examined the stimulatory effect of human myelin basic protein (MBP) on mononuclear cell (MNC) cultures from 22 patients with MS and 22 sex-matched and age-matched healthy individuals, and related the patient responses to disease activity, as indicated by magnetic resonance imaging. The MBP induced a dose-dependent release of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) by patient-derived MNCs. The patients' cells produced higher amounts of IFN-gamma and TNF-alpha, and lower amounts of IL-10, than cells from healthy controls (P

U2 - 10.1111/j.1365-2567.2008.02837.x

DO - 10.1111/j.1365-2567.2008.02837.x

M3 - Journal article

C2 - 18397264

VL - 125

SP - 161

EP - 169

JO - Immunology

JF - Immunology

SN - 0019-2805

IS - 2

ER -

ID: 10153167