The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance: Evidence of validity
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance : Evidence of validity. / Frisoni, Giovanni B; Jack, Clifford R; Bocchetta, Martina; Bauer, Corinna; Frederiksen, Kristian S; Liu, Yawu; Preboske, Gregory; Swihart, Tim; Blair, Melanie; Cavedo, Enrica; Grothe, Michel J; Lanfredi, Mariangela; Martinez, Oliver; Nishikawa, Masami; Portegies, Marileen; Stoub, Travis; Ward, Chadwich; Apostolova, Liana G; Ganzola, Rossana; Wolf, Dominik; Barkhof, Frederik; Bartzokis, George; DeCarli, Charles; Csernansky, John G; deToledo-Morrell, Leyla; Geerlings, Mirjam I; Kaye, Jeffrey; Killiany, Ronald J; Lehéricy, Stephane; Matsuda, Hiroshi; O'Brien, John; Silbert, Lisa C; Scheltens, Philip; Soininen, Hilkka; Teipel, Stefan; Waldemar, Gunhild; Fellgiebel, Andreas; Barnes, Josephine; Firbank, Michael; Gerritsen, Lotte; Henneman, Wouter; Malykhin, Nikolai; Pruessner, Jens C; Wang, Lei; Watson, Craig; Wolf, Henrike; deLeon, Mony; Pantel, Johannes; Ferrari, Clarissa; Bosco, Paolo; EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative.
I: Alzheimer's & Dementia, Bind 11, Nr. 2, 02.2015, s. 111-125.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The EADC-ADNI Harmonized Protocol for manual hippocampal segmentation on magnetic resonance
T2 - Evidence of validity
AU - Frisoni, Giovanni B
AU - Jack, Clifford R
AU - Bocchetta, Martina
AU - Bauer, Corinna
AU - Frederiksen, Kristian S
AU - Liu, Yawu
AU - Preboske, Gregory
AU - Swihart, Tim
AU - Blair, Melanie
AU - Cavedo, Enrica
AU - Grothe, Michel J
AU - Lanfredi, Mariangela
AU - Martinez, Oliver
AU - Nishikawa, Masami
AU - Portegies, Marileen
AU - Stoub, Travis
AU - Ward, Chadwich
AU - Apostolova, Liana G
AU - Ganzola, Rossana
AU - Wolf, Dominik
AU - Barkhof, Frederik
AU - Bartzokis, George
AU - DeCarli, Charles
AU - Csernansky, John G
AU - deToledo-Morrell, Leyla
AU - Geerlings, Mirjam I
AU - Kaye, Jeffrey
AU - Killiany, Ronald J
AU - Lehéricy, Stephane
AU - Matsuda, Hiroshi
AU - O'Brien, John
AU - Silbert, Lisa C
AU - Scheltens, Philip
AU - Soininen, Hilkka
AU - Teipel, Stefan
AU - Waldemar, Gunhild
AU - Fellgiebel, Andreas
AU - Barnes, Josephine
AU - Firbank, Michael
AU - Gerritsen, Lotte
AU - Henneman, Wouter
AU - Malykhin, Nikolai
AU - Pruessner, Jens C
AU - Wang, Lei
AU - Watson, Craig
AU - Wolf, Henrike
AU - deLeon, Mony
AU - Pantel, Johannes
AU - Ferrari, Clarissa
AU - Bosco, Paolo
AU - EADC-ADNI Working Group on The Harmonized Protocol for Manual Hippocampal Volumetry and for the Alzheimer's Disease Neuroimaging Initiative
N1 - Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.
PY - 2015/2
Y1 - 2015/2
N2 - BACKGROUND: An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.METHODS: Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.RESULTS: The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001).CONCLUSIONS: The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.
AB - BACKGROUND: An international Delphi panel has defined a harmonized protocol (HarP) for the manual segmentation of the hippocampus on MR. The aim of this study is to study the concurrent validity of the HarP toward local protocols, and its major sources of variance.METHODS: Fourteen tracers segmented 10 Alzheimer's Disease Neuroimaging Initiative (ADNI) cases scanned at 1.5 T and 3T following local protocols, qualified for segmentation based on the HarP through a standard web-platform and resegmented following the HarP. The five most accurate tracers followed the HarP to segment 15 ADNI cases acquired at three time points on both 1.5 T and 3T.RESULTS: The agreement among tracers was relatively low with the local protocols (absolute left/right ICC 0.44/0.43) and much higher with the HarP (absolute left/right ICC 0.88/0.89). On the larger set of 15 cases, the HarP agreement within (left/right ICC range: 0.94/0.95 to 0.99/0.99) and among tracers (left/right ICC range: 0.89/0.90) was very high. The volume variance due to different tracers was 0.9% of the total, comparing favorably to variance due to scanner manufacturer (1.2), atrophy rates (3.5), hemispheric asymmetry (3.7), field strength (4.4), and significantly smaller than the variance due to atrophy (33.5%, P < .001), and physiological variability (49.2%, P < .001).CONCLUSIONS: The HarP has high measurement stability compared with local segmentation protocols, and good reproducibility within and among human tracers. Hippocampi segmented with the HarP can be used as a reference for the qualification of human tracers and automated segmentation algorithms.
KW - Aged
KW - Alzheimer Disease
KW - Atrophy
KW - Female
KW - Functional Laterality
KW - Hippocampus
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Imaging, Three-Dimensional
KW - Internet
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Neuroimaging
KW - Organ Size
KW - Reproducibility of Results
U2 - 10.1016/j.jalz.2014.05.1756
DO - 10.1016/j.jalz.2014.05.1756
M3 - Journal article
C2 - 25267715
VL - 11
SP - 111
EP - 125
JO - Alzheimer's & Dementia
JF - Alzheimer's & Dementia
SN - 1552-5260
IS - 2
ER -
ID: 152932509