The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. / Nexø, Bjørn Andersen; Christensen, Tove; Frederiksen, Jette; Møller-Larsen, Anné; Oturai, Annette B; Fredsted, Palle Villesen; Hansen, Bettina; Nissen, Kari Konstantin; Laska, Magdalena Janina; Petersen, Trine Skov; Bonnesen, Sandra; Hedemand, Anne; Wu, Tingting; Wang, Xinjie; Zhang, Xiuqing; Brudek, Tomasz; Maric, Romana; Søndergaard, Helle B; Sellebjerg, Finn; Brusgaard, Klaus; Kjeldbjerg, Anders Langfelt; Rasmussen, Henrik B; Nielsen, Anders L; Nyegaard, Mette; Petersen, Thor; Børglum, Anders; Pedersen, Finn Skou.

I: P L o S One, Bind 6, Nr. 2, 01.02.2011, s. e16652.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nexø, BA, Christensen, T, Frederiksen, J, Møller-Larsen, A, Oturai, AB, Fredsted, PV, Hansen, B, Nissen, KK, Laska, MJ, Petersen, TS, Bonnesen, S, Hedemand, A, Wu, T, Wang, X, Zhang, X, Brudek, T, Maric, R, Søndergaard, HB, Sellebjerg, F, Brusgaard, K, Kjeldbjerg, AL, Rasmussen, HB, Nielsen, AL, Nyegaard, M, Petersen, T, Børglum, A & Pedersen, FS 2011, 'The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1', P L o S One, bind 6, nr. 2, s. e16652. https://doi.org/10.1371/journal.pone.0016652, https://doi.org/10.1371/journal.pone.0016652

APA

Nexø, B. A., Christensen, T., Frederiksen, J., Møller-Larsen, A., Oturai, A. B., Fredsted, P. V., Hansen, B., Nissen, K. K., Laska, M. J., Petersen, T. S., Bonnesen, S., Hedemand, A., Wu, T., Wang, X., Zhang, X., Brudek, T., Maric, R., Søndergaard, H. B., Sellebjerg, F., ... Pedersen, F. S. (2011). The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. P L o S One, 6(2), e16652. https://doi.org/10.1371/journal.pone.0016652, https://doi.org/10.1371/journal.pone.0016652

Vancouver

Nexø BA, Christensen T, Frederiksen J, Møller-Larsen A, Oturai AB, Fredsted PV o.a. The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. P L o S One. 2011 feb. 1;6(2):e16652. https://doi.org/10.1371/journal.pone.0016652, https://doi.org/10.1371/journal.pone.0016652

Author

Nexø, Bjørn Andersen ; Christensen, Tove ; Frederiksen, Jette ; Møller-Larsen, Anné ; Oturai, Annette B ; Fredsted, Palle Villesen ; Hansen, Bettina ; Nissen, Kari Konstantin ; Laska, Magdalena Janina ; Petersen, Trine Skov ; Bonnesen, Sandra ; Hedemand, Anne ; Wu, Tingting ; Wang, Xinjie ; Zhang, Xiuqing ; Brudek, Tomasz ; Maric, Romana ; Søndergaard, Helle B ; Sellebjerg, Finn ; Brusgaard, Klaus ; Kjeldbjerg, Anders Langfelt ; Rasmussen, Henrik B ; Nielsen, Anders L ; Nyegaard, Mette ; Petersen, Thor ; Børglum, Anders ; Pedersen, Finn Skou. / The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1. I: P L o S One. 2011 ; Bind 6, Nr. 2. s. e16652.

Bibtex

@article{8a7f5a960a6647e5ba175afbc63e285c,
title = "The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1",
abstract = "We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.",
author = "Nex{\o}, {Bj{\o}rn Andersen} and Tove Christensen and Jette Frederiksen and Ann{\'e} M{\o}ller-Larsen and Oturai, {Annette B} and Fredsted, {Palle Villesen} and Bettina Hansen and Nissen, {Kari Konstantin} and Laska, {Magdalena Janina} and Petersen, {Trine Skov} and Sandra Bonnesen and Anne Hedemand and Tingting Wu and Xinjie Wang and Xiuqing Zhang and Tomasz Brudek and Romana Maric and S{\o}ndergaard, {Helle B} and Finn Sellebjerg and Klaus Brusgaard and Kjeldbjerg, {Anders Langfelt} and Rasmussen, {Henrik B} and Nielsen, {Anders L} and Mette Nyegaard and Thor Petersen and Anders B{\o}rglum and Pedersen, {Finn Skou}",
year = "2011",
month = feb,
day = "1",
doi = "10.1371/journal.pone.0016652",
language = "English",
volume = "6",
pages = "e16652",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - The etiology of multiple sclerosis: genetic evidence for the involvement of the human endogenous retrovirus HERV-Fc1

AU - Nexø, Bjørn Andersen

AU - Christensen, Tove

AU - Frederiksen, Jette

AU - Møller-Larsen, Anné

AU - Oturai, Annette B

AU - Fredsted, Palle Villesen

AU - Hansen, Bettina

AU - Nissen, Kari Konstantin

AU - Laska, Magdalena Janina

AU - Petersen, Trine Skov

AU - Bonnesen, Sandra

AU - Hedemand, Anne

AU - Wu, Tingting

AU - Wang, Xinjie

AU - Zhang, Xiuqing

AU - Brudek, Tomasz

AU - Maric, Romana

AU - Søndergaard, Helle B

AU - Sellebjerg, Finn

AU - Brusgaard, Klaus

AU - Kjeldbjerg, Anders Langfelt

AU - Rasmussen, Henrik B

AU - Nielsen, Anders L

AU - Nyegaard, Mette

AU - Petersen, Thor

AU - Børglum, Anders

AU - Pedersen, Finn Skou

PY - 2011/2/1

Y1 - 2011/2/1

N2 - We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

AB - We have investigated the role of human endogenous retroviruses in multiple sclerosis by analyzing the DNA of patients and controls in 4 cohorts for associations between multiple sclerosis and polymorphisms near viral restriction genes or near endogenous retroviral loci with one or more intact or almost-intact genes. We found that SNPs in the gene TRIM5 were inversely correlated with disease. Conversely, SNPs around one retroviral locus, HERV-Fc1, showed a highly significant association with disease. The latter association was limited to a narrow region that contains no other known genes. We conclude that HERV-Fc1 and TRIM5 play a role in the etiology of multiple sclerosis. If these results are confirmed, they point to new modes of treatment for multiple sclerosis.

U2 - 10.1371/journal.pone.0016652

DO - 10.1371/journal.pone.0016652

M3 - Journal article

VL - 6

SP - e16652

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 2

ER -

ID: 34123615