The role of gluten in multiple sclerosis, psoriasis, autoimmune thyroid diseases and type 1 diabetes
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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The role of gluten in multiple sclerosis, psoriasis, autoimmune thyroid diseases and type 1 diabetes. / Passali, Moschoula; Antvorskov, Julie; Frederiksen, Jette; Josefsen, Knud.
Coeliac Disease and Gluten-Related Disorders. Academic Press, 2022. s. 223-246.Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - The role of gluten in multiple sclerosis, psoriasis, autoimmune thyroid diseases and type 1 diabetes
AU - Passali, Moschoula
AU - Antvorskov, Julie
AU - Frederiksen, Jette
AU - Josefsen, Knud
N1 - Publisher Copyright: © 2022 Elsevier Inc. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Adhering to a gluten-free diet (GFD) is becoming a popular health trend. In this chapter we summarize the current clinical evidence on a potential role for gluten in multiple sclerosis (MS), psoriasis, autoimmune thyroid diseases (ATD), and type 1 diabetes (T1D). Patients with celiac disease have increased risk of ATD, T1D, psoriasis and vice versa, however this is not the case for MS. One clinical trial has found protective effects of a GFD among patients with MS. A few studies suggest that a subgroup of patients with psoriasis presenting gliadin antibodies can benefit from a GFD. No studies have investigated the effects of a GFD in nonceliac patients with ATD, however, some publications suggest that thyroid-related antibodies may respond to a GFD in patients with confirmed CD or tissue transglutaminase antibodies. Lastly, results on the effects of a GFD among patients with T1D are inconsistent, however, it seems likely that a GFD may contribute to normalizing metabolic control possibly by preserving the function of the remaining beta-cells. Altogether, the above results have to be replicated in properly controlled intervention trials of adequate power before we can recommend a GFD to subgroups of patients with autoimmune disorders.
AB - Adhering to a gluten-free diet (GFD) is becoming a popular health trend. In this chapter we summarize the current clinical evidence on a potential role for gluten in multiple sclerosis (MS), psoriasis, autoimmune thyroid diseases (ATD), and type 1 diabetes (T1D). Patients with celiac disease have increased risk of ATD, T1D, psoriasis and vice versa, however this is not the case for MS. One clinical trial has found protective effects of a GFD among patients with MS. A few studies suggest that a subgroup of patients with psoriasis presenting gliadin antibodies can benefit from a GFD. No studies have investigated the effects of a GFD in nonceliac patients with ATD, however, some publications suggest that thyroid-related antibodies may respond to a GFD in patients with confirmed CD or tissue transglutaminase antibodies. Lastly, results on the effects of a GFD among patients with T1D are inconsistent, however, it seems likely that a GFD may contribute to normalizing metabolic control possibly by preserving the function of the remaining beta-cells. Altogether, the above results have to be replicated in properly controlled intervention trials of adequate power before we can recommend a GFD to subgroups of patients with autoimmune disorders.
KW - Anti-gliadin antibodies
KW - Autoimmune thyroid diseases
KW - Autoimmunity
KW - Celiac disease
KW - Gliadin
KW - Gluten
KW - Gluten-free diet
KW - Multiple sclerosis
KW - Psoriasis
KW - Tissue transglutaminase
KW - Type 1 diabetes
U2 - 10.1016/B978-0-12-821571-5.00003-9
DO - 10.1016/B978-0-12-821571-5.00003-9
M3 - Book chapter
AN - SCOPUS:85139313719
SN - 9780128215722
SP - 223
EP - 246
BT - Coeliac Disease and Gluten-Related Disorders
PB - Academic Press
ER -
ID: 344851954