The SH2D2A gene and susceptibility to multiple sclerosis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid position 52 in TSAd. The GA(16)-rs926103()A haplotype was associated with MS in Norwegians (OR 1.4, P=0.04). A similar trend was observed among Danes. In the independent Norwegian, Danish and Swedish sample sets the GA(16) allele showed a combined OR of 1.13, P=0.05. Thus, the present study shows that the SH2D2A gene may contribute to susceptibility to MS
Udgivelsesdato: 2008/7/15
Udgivelsesdato: 2008/7/15
Originalsprog | Engelsk |
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Tidsskrift | Journal of Neuroimmunology |
Vol/bind | 197 |
Udgave nummer | 2 |
Sider (fra-til) | 152-158 |
Antal sider | 6 |
ISSN | 0165-5728 |
Status | Udgivet - 2008 |
ID: 10924678