The value of conventional high-field MRI in MS in the light of the McDonald criteria: a literature review
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The value of conventional high-field MRI in MS in the light of the McDonald criteria: a literature review. / Larsen, Line Sofie Lunde; Larsson, H B W; Frederiksen, Jette Lautrup Battistini.
I: Acta Neurologica Scandinavica, Bind 122, Nr. 3, 01.09.2010, s. 149-58.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The value of conventional high-field MRI in MS in the light of the McDonald criteria: a literature review
AU - Larsen, Line Sofie Lunde
AU - Larsson, H B W
AU - Frederiksen, Jette Lautrup Battistini
PY - 2010/9/1
Y1 - 2010/9/1
N2 - The diagnosis of MS is based on the revised McDonald criteria and is multidisciplinary. Both clinical and paraclinical measures are included. High-field magnetic resonance imaging (MRI) is becoming increasingly available and it is therefore necessary to clarify possible advantages of high-field MRI in MS. The aim of this paper was to review MRI studies in MS where a direct comparison of MRI at high field with MRI at 1-1.5 tesla (T) had been performed. The studies evaluated were found by searching Pubmed with relevant terms including MeSH terms. The reviewed studies all found the conspicuity of lesions to be better at high field. Of the seven studies, six found more and bigger lesions at high-field MRI. In the present paper, the relevant MRI sequences are evaluated in detail. The detection of more lesions at high-field strength did not seem to lead to earlier diagnosis of clinically definite multiple sclerosis. Further larger studies of patients with clinically isolated syndromes are needed to settle the question of a diagnostic consequence of high-field imaging in MS. We suggest that the next revision of the McDonald diagnostic criteria include a recommendation of field strength.
AB - The diagnosis of MS is based on the revised McDonald criteria and is multidisciplinary. Both clinical and paraclinical measures are included. High-field magnetic resonance imaging (MRI) is becoming increasingly available and it is therefore necessary to clarify possible advantages of high-field MRI in MS. The aim of this paper was to review MRI studies in MS where a direct comparison of MRI at high field with MRI at 1-1.5 tesla (T) had been performed. The studies evaluated were found by searching Pubmed with relevant terms including MeSH terms. The reviewed studies all found the conspicuity of lesions to be better at high field. Of the seven studies, six found more and bigger lesions at high-field MRI. In the present paper, the relevant MRI sequences are evaluated in detail. The detection of more lesions at high-field strength did not seem to lead to earlier diagnosis of clinically definite multiple sclerosis. Further larger studies of patients with clinically isolated syndromes are needed to settle the question of a diagnostic consequence of high-field imaging in MS. We suggest that the next revision of the McDonald diagnostic criteria include a recommendation of field strength.
U2 - http://dx.doi.org/10.1111/j.1600-0404.2010.01403.x
DO - http://dx.doi.org/10.1111/j.1600-0404.2010.01403.x
M3 - Journal article
VL - 122
SP - 149
EP - 158
JO - Acta Neurologica Scandinavica
JF - Acta Neurologica Scandinavica
SN - 0001-6314
IS - 3
ER -
ID: 34065852