Upwards Drift of Cerebrospinal Fluid Amyloid-β 42 over Twelve Years in a Consecutive Clinical Cohort
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Amyloid-β 1-42 (Aβ1-42) measured in the cerebrospinal fluid (CSF) can be used as a diagnostic biomarker for Alzheimer's disease (AD) but an upward drift when using the INNOTEST ELISA has been suggested. We investigated the upwards drift of Aβ1-42 levels over a period of twelve years in a consecutive memory clinic cohort. We found a significant increase in Aβ1-42 from 2008 to 2019 independent of changes in tau. New methods for the quantification of CSF Aβ1-42 levels are being implemented but awareness of this upwards drift is crucial during the diagnostic work-up and when selecting historical samples for research.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Alzheimer's Disease |
Vol/bind | 81 |
Udgave nummer | 4 |
Sider (fra-til) | 1369-1373 |
ISSN | 1387-2877 |
DOI | |
Status | Udgivet - 2021 |
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