Vaccines and multiple sclerosis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Vaccines and multiple sclerosis. / Frederiksen, J. L.; Topsøe Mailand, M.
I: Acta Neurologica Scandinavica, Bind 136, Nr. S201, 01.11.2017, s. 49-51.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Vaccines and multiple sclerosis
AU - Frederiksen, J. L.
AU - Topsøe Mailand, M.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - An association between certain vaccinations and onset or relapse of multiple sclerosis (MS) has been debated. Based on PubMed, we made a thorough literature review and included all relevant studies, 51 on MS and 15 on optic neuritis (ON). Case studies were excluded. With the exception of a live vaccine against yellow fever, vaccinations appear safe in untreated patients with MS and ON. However, most studies were underpowered, and small risks cannot be excluded. One study of BCG vaccination after the first demyelinating event showed even a reduced risk of developing MS. Further studies are needed to fully exclude a causal association.
AB - An association between certain vaccinations and onset or relapse of multiple sclerosis (MS) has been debated. Based on PubMed, we made a thorough literature review and included all relevant studies, 51 on MS and 15 on optic neuritis (ON). Case studies were excluded. With the exception of a live vaccine against yellow fever, vaccinations appear safe in untreated patients with MS and ON. However, most studies were underpowered, and small risks cannot be excluded. One study of BCG vaccination after the first demyelinating event showed even a reduced risk of developing MS. Further studies are needed to fully exclude a causal association.
KW - multiple sclerosis
KW - optic neuritis
KW - vaccination
UR - http://www.scopus.com/inward/record.url?scp=85032198775&partnerID=8YFLogxK
U2 - 10.1111/ane.12837
DO - 10.1111/ane.12837
M3 - Review
C2 - 29068486
AN - SCOPUS:85032198775
VL - 136
SP - 49
EP - 51
JO - Acta Neurologica Scandinavica, Supplement
JF - Acta Neurologica Scandinavica, Supplement
SN - 0065-1427
IS - S201
ER -
ID: 188163131