Validation of the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural sample across five Western European countries: diagnostic accuracy and normative data
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Validation of the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural sample across five Western European countries : diagnostic accuracy and normative data. / Nielsen, T Rune; Segers, Kurt; Vanderaspoilden, Valérie; Bekkhus-Wetterberg, Peter; Bjørkløf, Guro Hanevold; Beinhoff, Ulrike; Minthon, Lennart; Pissiota, Anna; Tsolaki, Magda; Gkioka, Mara; Waldemar, Gunhild.
I: International Psychogeriatrics, Bind 31, Nr. 2, 02.2019, s. 287-296.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Validation of the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural sample across five Western European countries
T2 - diagnostic accuracy and normative data
AU - Nielsen, T Rune
AU - Segers, Kurt
AU - Vanderaspoilden, Valérie
AU - Bekkhus-Wetterberg, Peter
AU - Bjørkløf, Guro Hanevold
AU - Beinhoff, Ulrike
AU - Minthon, Lennart
AU - Pissiota, Anna
AU - Tsolaki, Magda
AU - Gkioka, Mara
AU - Waldemar, Gunhild
PY - 2019/2
Y1 - 2019/2
N2 - ABSTRACTBackground:With increasing cultural diversity and growing elderly immigrant populations in Western European countries, the availability of brief cognitive screening instruments adequate for assessment of dementia in people from diverse backgrounds becomes increasingly important. The aim of the present study was to investigate diagnostic accuracy of the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural sample and to calculate normative data as a basis for demographic adjustment of RUDAS scores.METHODS: The study was a prospective international cross-sectional multi-center study. Receiver operating characteristic curve analysis was used to examine diagnostic accuracy. Regression analysis was used to assess the impact of demographic variables.RESULTS: Data was collected from 341 cognitively intact participants and 80 people with dementia with a wide age- and educational range. Of the 421 included participants, 239 (57%) had immigrant background. The RUDAS had high diagnostic accuracy with an area under the curve (AUC) of 0.93. The optimal cut-off score was <25 (sensitivity 0.80, specificity 0.90). Regression analysis revealed that RUDAS scores were mainly affected by education and were unrelated to data collection site and immigrant status. Education-adjusted normative data was calculated as a basis for education adjustment of RUDAS scores. Applying education-adjusted RUDAS scores slightly but significantly improved diagnostic accuracy with an AUC of 0.95.CONCLUSION: We found the RUDAS to have excellent diagnostic properties in our multicultural sample. However, we suggest that RUDAS scores should be adjusted for education to increase diagnostic accuracy and that the choice of cut-off score should be considered based on the clinical context and expected base rate of dementia.
AB - ABSTRACTBackground:With increasing cultural diversity and growing elderly immigrant populations in Western European countries, the availability of brief cognitive screening instruments adequate for assessment of dementia in people from diverse backgrounds becomes increasingly important. The aim of the present study was to investigate diagnostic accuracy of the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural sample and to calculate normative data as a basis for demographic adjustment of RUDAS scores.METHODS: The study was a prospective international cross-sectional multi-center study. Receiver operating characteristic curve analysis was used to examine diagnostic accuracy. Regression analysis was used to assess the impact of demographic variables.RESULTS: Data was collected from 341 cognitively intact participants and 80 people with dementia with a wide age- and educational range. Of the 421 included participants, 239 (57%) had immigrant background. The RUDAS had high diagnostic accuracy with an area under the curve (AUC) of 0.93. The optimal cut-off score was <25 (sensitivity 0.80, specificity 0.90). Regression analysis revealed that RUDAS scores were mainly affected by education and were unrelated to data collection site and immigrant status. Education-adjusted normative data was calculated as a basis for education adjustment of RUDAS scores. Applying education-adjusted RUDAS scores slightly but significantly improved diagnostic accuracy with an AUC of 0.95.CONCLUSION: We found the RUDAS to have excellent diagnostic properties in our multicultural sample. However, we suggest that RUDAS scores should be adjusted for education to increase diagnostic accuracy and that the choice of cut-off score should be considered based on the clinical context and expected base rate of dementia.
KW - Aged
KW - Aged, 80 and over
KW - Cross-Sectional Studies
KW - Cultural Diversity
KW - Dementia/diagnosis
KW - Europe
KW - Female
KW - Geriatric Assessment
KW - Humans
KW - Internationality
KW - Male
KW - Middle Aged
KW - Neuropsychological Tests/standards
KW - Prospective Studies
KW - ROC Curve
KW - Regression Analysis
KW - Sensitivity and Specificity
U2 - 10.1017/S1041610218000832
DO - 10.1017/S1041610218000832
M3 - Journal article
C2 - 30017010
VL - 31
SP - 287
EP - 296
JO - International Psychogeriatrics
JF - International Psychogeriatrics
SN - 1041-6102
IS - 2
ER -
ID: 235003823