Variation in NOD2 augments Th2- and Th17 responses to myelin basic protein in multiple sclerosis

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Standard

Variation in NOD2 augments Th2- and Th17 responses to myelin basic protein in multiple sclerosis. / Hedegaard, Chris Juul; Enevold, Christian; Sellebjerg, Finn; Bendtzen, Klaus; Nielsen, Claus Henrik.

I: P L o S One, Bind 6, Nr. 5, 2011, s. e20253.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hedegaard, CJ, Enevold, C, Sellebjerg, F, Bendtzen, K & Nielsen, CH 2011, 'Variation in NOD2 augments Th2- and Th17 responses to myelin basic protein in multiple sclerosis', P L o S One, bind 6, nr. 5, s. e20253. https://doi.org/10.1371/journal.pone.0020253

APA

Hedegaard, C. J., Enevold, C., Sellebjerg, F., Bendtzen, K., & Nielsen, C. H. (2011). Variation in NOD2 augments Th2- and Th17 responses to myelin basic protein in multiple sclerosis. P L o S One, 6(5), e20253. https://doi.org/10.1371/journal.pone.0020253

Vancouver

Hedegaard CJ, Enevold C, Sellebjerg F, Bendtzen K, Nielsen CH. Variation in NOD2 augments Th2- and Th17 responses to myelin basic protein in multiple sclerosis. P L o S One. 2011;6(5):e20253. https://doi.org/10.1371/journal.pone.0020253

Author

Hedegaard, Chris Juul ; Enevold, Christian ; Sellebjerg, Finn ; Bendtzen, Klaus ; Nielsen, Claus Henrik. / Variation in NOD2 augments Th2- and Th17 responses to myelin basic protein in multiple sclerosis. I: P L o S One. 2011 ; Bind 6, Nr. 5. s. e20253.

Bibtex

@article{436ed41f7b3a47bc91eca25343042121,
title = "Variation in NOD2 augments Th2- and Th17 responses to myelin basic protein in multiple sclerosis",
abstract = "Variations in the gene for the nucleotide-binding oligomerisation domain (NOD) 2 have been associated with Crohn's disease but not multiple sclerosis (MS). Here we investigate the effect of three polymorphisms in the NOD2 gene (rs5743277, rs2066842 and rs5743291) on cytokine production and CD4+ T cell proliferation elicited by human myelin basic protein (MBP) in blood mononuclear cell (MNC) cultures from 29 patients with MS. No polymorphism was observed at rs5743277. No associations with the rs2066842 polymorphism were found. Concerning rs5743291, none were homozygous for the minor allele. Seven of 29 (24%) patients were heterozygous, and five of these (71%) exhibited increased MBP-induced CD4+ T cell proliferation versus four of 22 (18%), who were homozygous for the major allele (p",
author = "Hedegaard, {Chris Juul} and Christian Enevold and Finn Sellebjerg and Klaus Bendtzen and Nielsen, {Claus Henrik}",
year = "2011",
doi = "http://dx.doi.org/10.1371/journal.pone.0020253",
language = "English",
volume = "6",
pages = "e20253",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "5",

}

RIS

TY - JOUR

T1 - Variation in NOD2 augments Th2- and Th17 responses to myelin basic protein in multiple sclerosis

AU - Hedegaard, Chris Juul

AU - Enevold, Christian

AU - Sellebjerg, Finn

AU - Bendtzen, Klaus

AU - Nielsen, Claus Henrik

PY - 2011

Y1 - 2011

N2 - Variations in the gene for the nucleotide-binding oligomerisation domain (NOD) 2 have been associated with Crohn's disease but not multiple sclerosis (MS). Here we investigate the effect of three polymorphisms in the NOD2 gene (rs5743277, rs2066842 and rs5743291) on cytokine production and CD4+ T cell proliferation elicited by human myelin basic protein (MBP) in blood mononuclear cell (MNC) cultures from 29 patients with MS. No polymorphism was observed at rs5743277. No associations with the rs2066842 polymorphism were found. Concerning rs5743291, none were homozygous for the minor allele. Seven of 29 (24%) patients were heterozygous, and five of these (71%) exhibited increased MBP-induced CD4+ T cell proliferation versus four of 22 (18%), who were homozygous for the major allele (p

AB - Variations in the gene for the nucleotide-binding oligomerisation domain (NOD) 2 have been associated with Crohn's disease but not multiple sclerosis (MS). Here we investigate the effect of three polymorphisms in the NOD2 gene (rs5743277, rs2066842 and rs5743291) on cytokine production and CD4+ T cell proliferation elicited by human myelin basic protein (MBP) in blood mononuclear cell (MNC) cultures from 29 patients with MS. No polymorphism was observed at rs5743277. No associations with the rs2066842 polymorphism were found. Concerning rs5743291, none were homozygous for the minor allele. Seven of 29 (24%) patients were heterozygous, and five of these (71%) exhibited increased MBP-induced CD4+ T cell proliferation versus four of 22 (18%), who were homozygous for the major allele (p

U2 - http://dx.doi.org/10.1371/journal.pone.0020253

DO - http://dx.doi.org/10.1371/journal.pone.0020253

M3 - Journal article

VL - 6

SP - e20253

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 5

ER -

ID: 40194257