White matter changes contribute to corpus callosum atrophy in the elderly: the LADIS study
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White matter changes contribute to corpus callosum atrophy in the elderly: the LADIS study. / Ryberg, C; Rostrup, E; Sjöstrand, Karl; Paulson, O B; Barkhof, F; Scheltens, P; van Straaten, E C W; Fazekas, F; Schmidt, R; Erkinjuntti, T; Wahlund, L-O; Basile, Alessio; Pantoni, L; Inzitari, D; Waldemar, G; LADIS study group.
I: American Journal of Neuroradiology, Bind 29, Nr. 8, 2008, s. 1498-1504.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - White matter changes contribute to corpus callosum atrophy in the elderly: the LADIS study
AU - Ryberg, C
AU - Rostrup, E
AU - Sjöstrand, Karl
AU - Paulson, O B
AU - Barkhof, F
AU - Scheltens, P
AU - van Straaten, E C W
AU - Fazekas, F
AU - Schmidt, R
AU - Erkinjuntti, T
AU - Wahlund, L-O
AU - Basile, Alessio
AU - Pantoni, L
AU - Inzitari, D
AU - Waldemar, G
AU - LADIS study group
PY - 2008
Y1 - 2008
N2 - BACKGROUND AND PURPOSE: The corpus callosum (CC) is the most important structure involved in the transmission of interhemispheric information. The aim of this study was to investigate the potential correlation between regional age-related white matter changes (ARWMC) and atrophy of CC in elderly subjects. MATERIALS AND METHODS: In 578 subjects with ARWMC from the Leukoaraiosis And DISability (LADIS) study, the cross-sectional area of the CC was automatically segmented on the normalized midsagittal MR imaging section and subdivided into 5 regions. The ARWMC volumes were measured quantitatively by using a semiautomated technique and segmented into 6 brain regions. RESULTS: Significant correlation between the area of the rostrum and splenium regions of the CC and the ARWMC load in most brain regions was identified. This correlation persisted after correction for global atrophy. CONCLUSION: Increasing loads of ARWMC volume were significantly correlated with atrophy of the CC and its subregions in nondisabled elderly subjects with leukoaraiosis. However, the pattern of correlation between CC subregions and ARWMC was not specifically related to the topographic location of ARWMC. The results suggest that ARWMC may lead to a gradual loss of CC tissue.
AB - BACKGROUND AND PURPOSE: The corpus callosum (CC) is the most important structure involved in the transmission of interhemispheric information. The aim of this study was to investigate the potential correlation between regional age-related white matter changes (ARWMC) and atrophy of CC in elderly subjects. MATERIALS AND METHODS: In 578 subjects with ARWMC from the Leukoaraiosis And DISability (LADIS) study, the cross-sectional area of the CC was automatically segmented on the normalized midsagittal MR imaging section and subdivided into 5 regions. The ARWMC volumes were measured quantitatively by using a semiautomated technique and segmented into 6 brain regions. RESULTS: Significant correlation between the area of the rostrum and splenium regions of the CC and the ARWMC load in most brain regions was identified. This correlation persisted after correction for global atrophy. CONCLUSION: Increasing loads of ARWMC volume were significantly correlated with atrophy of the CC and its subregions in nondisabled elderly subjects with leukoaraiosis. However, the pattern of correlation between CC subregions and ARWMC was not specifically related to the topographic location of ARWMC. The results suggest that ARWMC may lead to a gradual loss of CC tissue.
KW - Aged
KW - Brain
KW - Corpus Callosum
KW - Europe
KW - Female
KW - Humans
KW - Leukoaraiosis
KW - Magnetic Resonance Imaging
KW - Male
KW - Nerve Fibers, Myelinated
KW - Prevalence
U2 - 10.3174/ajnr.A1169
DO - 10.3174/ajnr.A1169
M3 - Journal article
C2 - 18556357
VL - 29
SP - 1498
EP - 1504
JO - American Journal of Neuroradiology
JF - American Journal of Neuroradiology
SN - 0195-6108
IS - 8
ER -
ID: 10949795