White matter hyperintensities and prepulse inhibition in a mixed elderly population
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White matter hyperintensities and prepulse inhibition in a mixed elderly population. / Salem, Lise C; Hejl, Anne-Mette; Garde, Ellen; Leffers, Anne Mette; Paulson, Olaf B; Waldemar, Gunhild.
I: Psychiatry Research, Bind 194, Nr. 3, 2011, s. 314-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - White matter hyperintensities and prepulse inhibition in a mixed elderly population
AU - Salem, Lise C
AU - Hejl, Anne-Mette
AU - Garde, Ellen
AU - Leffers, Anne Mette
AU - Paulson, Olaf B
AU - Waldemar, Gunhild
N1 - 2011 Elsevier Ireland Ltd. All rights reserved.
PY - 2011
Y1 - 2011
N2 - Prepulse inhibition (PPI) of the startle response, a measure for sensorimotor gating, exhibits a relatively high inter-individual variability in elderly subjects. The aim of this study was to investigate whether white matter hyperintensities (WMH), frequently identified on cranial magnetic resonance imaging (MRI) in elderly subjects with and without cognitive impairment, may contribute to variations in PPI. A passive acoustic PPI paradigm was applied in 92 human subjects (53 healthy and 39 patients with Alzheimer's disease or mild cognitive impairment) between 60 and 85years of age. WMH were rated visually on craniel MRI FLAIR images using the Fazekas scale. WMH were identified in 70% of all subjects. The latency to peak of the startle response increased significantly with increasing WMH load, whereas the inhibition of the startle response (PPI) was neither significantly related to the degree of WMH nor to cognitive performance. We conclude that the presence of WMH in the fronto-striatal brain circuit may affect the latency of the startle response, but not information processing in elderly subjects.
AB - Prepulse inhibition (PPI) of the startle response, a measure for sensorimotor gating, exhibits a relatively high inter-individual variability in elderly subjects. The aim of this study was to investigate whether white matter hyperintensities (WMH), frequently identified on cranial magnetic resonance imaging (MRI) in elderly subjects with and without cognitive impairment, may contribute to variations in PPI. A passive acoustic PPI paradigm was applied in 92 human subjects (53 healthy and 39 patients with Alzheimer's disease or mild cognitive impairment) between 60 and 85years of age. WMH were rated visually on craniel MRI FLAIR images using the Fazekas scale. WMH were identified in 70% of all subjects. The latency to peak of the startle response increased significantly with increasing WMH load, whereas the inhibition of the startle response (PPI) was neither significantly related to the degree of WMH nor to cognitive performance. We conclude that the presence of WMH in the fronto-striatal brain circuit may affect the latency of the startle response, but not information processing in elderly subjects.
U2 - 10.1016/j.pscychresns.2011.07.007
DO - 10.1016/j.pscychresns.2011.07.007
M3 - Journal article
VL - 194
SP - 314
EP - 318
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
IS - 3
ER -
ID: 40203816