Effect of exercise therapy versus surgery on mechanical symptoms in young patients with a meniscal tear: a secondary analysis of the DREAM trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Camma Damsted
  • Jonas Bloch Thorlund
  • Hølmich, Per
  • Martin Lind
  • Claus Varnum
  • Martin Dalgaard Villumsen
  • Mogens Strange Hansen
  • Søren T. Skou

Objective To compare the effect of early surgery versus exercise and education on mechanical symptoms and other patient-reported outcomes in patients aged 18-40 years with a meniscal tear and self-reported mechanical knee symptoms. Methods In a randomised controlled trial, 121 patients aged 18-40 years with a MRI-verified meniscal tear were randomised to surgery or 12-week supervised exercise and education. For this study, 63 patients (33 and 30 patients in the surgery and in the exercise group, respectively) reporting baseline mechanical symptoms were included. The main outcome was self-reported mechanical symptoms (yes/no) at 3, 6 and 12 months assessed using a single item from the Knee Injury and Osteoarthritis Outcome Score (KOOS). Secondary outcomes were KOOS 4 and the 5 KOOS-subscales and the Western Ontario Meniscal Evaluation Tool (WOMET). Results In total, 55/63 patients completed the 12-month follow-up. At 12 months, 9/26 (35%) in the surgery group and 20/29 (69%) in the exercise group reported mechanical symptoms. The risk difference and relative risk at any time point was 28.7% (95% CI 8.6% to 48.8%) and 1.83 (95% CI 0.98 to 2.70) of reporting mechanical symptoms in the exercise group compared with the surgery group. We did not detect any between-group differences in the secondary outcomes. Conclusion The results from this secondary analysis suggest that early surgery is more effective than exercise and education for relieving self-reported mechanical knee symptoms, but not for improving pain, function and quality of life in young patients with a meniscal tear and mechanical symptoms. Trial registration number NCT02995551.

OriginalsprogEngelsk
TidsskriftBritish Journal of Sports Medicine
Vol/bind57
Udgave nummer9
Sider (fra-til)521-527
ISSN0306-3674
DOI
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
Independent Research Fund Denmark and Sapere Aude Research Talent Award (DFF-6110-00045, DFF-6110-00045B), IMK Almene Fond, Lundbeck Foundation, Spar Nord Foundation, Danish Rheumatism Association, Association of Danish Physiotherapists Research Fund, Research Council at Næstved-Slagelse-Ringsted Hospitals and Region Zealand (Exercise First programme grant). The funders of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. Outside the submitted study, STS is currently funded by two grants from the European Union’s Horizon 2020 research and innovation program, one from the European Research Council (MOBILIZE, grant agreement No 801790) and the other under grant agreement No 945377 (ESCAPE).

Publisher Copyright:
© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.

ID: 370477652