TY - JOUR

T1 - Psychiatric comorbidity in childhood onset immune-mediated diseases

T2 - A systematic review and meta-analysis

AU - Jansson, Sabine

AU - Malham, Mikkel

AU - Wewer, Vibeke

AU - Rask, Charlotte Ulrikka

N1 - Funding Information: S. Jansson was supported with a research year scholarship from the Lundbeck Foundation Publisher Copyright: © 2022 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd.

PY - 2022

Y1 - 2022

N2 - Aim: To estimate psychiatric comorbidity in childhood onset immune-mediated inflammatory diseases (IMID).MethodsThe PRISMA guidelines were followed, and the protocol was registered at Prospero (ID: CRD42021233890). Literature was searched in PubMed, PsycINFO and Embase. Original papers on prevalence rates of diagnosed psychiatric disorders and/or suicide in paediatric onset inflammatory bowel disease (pIBD), rheumatic diseases (RD) and autoimmune liver diseases were selected. Pooled prevalence rates of psychiatric disorders (grouped according to ICD-10 criteria) within the various IMID were calculated using random-effects meta-analysis. Risk of bias was evaluated by the Newcastle-Ottawa scale.ResultsTwenty-three studies were included; 13 describing psychiatric disorders in pIBD and 10 in RD. Anxiety and mood disorders were mostly investigated with pooled prevalence rates in pIBD of 6% (95% confidence interval (CI): 4%–9%) and 4% (95%CI: 2%–8%), respectively, in register-based studies, and 33% (95%CI: 25%–41%) and 18% (95%CI: 12%–26%), respectively, in studies using psychiatric assessment. In RD, rates were 13% (95%CI: 12%–15%) for anxiety disorders and 20% (95%CI: 15%–26%) for mood disorders based on psychiatric assessment.ConclusionAnxiety and depression are commonly reported in childhood onset IMID. Physicians should be attentive to mental health problems in these patients as they seem overlooked.

AB - Aim: To estimate psychiatric comorbidity in childhood onset immune-mediated inflammatory diseases (IMID).MethodsThe PRISMA guidelines were followed, and the protocol was registered at Prospero (ID: CRD42021233890). Literature was searched in PubMed, PsycINFO and Embase. Original papers on prevalence rates of diagnosed psychiatric disorders and/or suicide in paediatric onset inflammatory bowel disease (pIBD), rheumatic diseases (RD) and autoimmune liver diseases were selected. Pooled prevalence rates of psychiatric disorders (grouped according to ICD-10 criteria) within the various IMID were calculated using random-effects meta-analysis. Risk of bias was evaluated by the Newcastle-Ottawa scale.ResultsTwenty-three studies were included; 13 describing psychiatric disorders in pIBD and 10 in RD. Anxiety and mood disorders were mostly investigated with pooled prevalence rates in pIBD of 6% (95% confidence interval (CI): 4%–9%) and 4% (95%CI: 2%–8%), respectively, in register-based studies, and 33% (95%CI: 25%–41%) and 18% (95%CI: 12%–26%), respectively, in studies using psychiatric assessment. In RD, rates were 13% (95%CI: 12%–15%) for anxiety disorders and 20% (95%CI: 15%–26%) for mood disorders based on psychiatric assessment.ConclusionAnxiety and depression are commonly reported in childhood onset IMID. Physicians should be attentive to mental health problems in these patients as they seem overlooked.

KW - autoimmune liver disease

KW - inflammatory bowel disease

KW - mental health

KW - rheumatic disease

KW - suicide

U2 - 10.1111/apa.16246

DO - 10.1111/apa.16246

M3 - Review

C2 - 34986519

AN - SCOPUS:85123891000

VL - 111

SP - 490

EP - 499

JO - Acta Paediatrica

JF - Acta Paediatrica

SN - 0803-5253

IS - 3

ER -