School performance and psychiatric comorbidity in childhood absence epilepsy: A Danish cohort study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
We reviewed the medical records in children with ICD-10 codes for idiopathic generalized epilepsy before 18 years of age, and pediatric neurologists confirmed the International League Against Epilepsy criteria for CAE were met. Control groups were the general pediatric population or children with non-neurological chronic disease. Outcomes were from nationwide and population-based registers on school performance and psychiatric comorbidity. We compared the mean grade point average using linear regression and estimated hazard ratios (HR) using Cox regression for the other outcomes. Analyses were adjusted for the child’s sex, and year of birth, and parental highest education, receipt of cash benefits or early disability pension.
We included 114 children with CAE with a median age at onset of 5.9 years (interquartile range = 4.5–7.3 years). Compared with both population controls and non-neurological chronically ill children, children with CAE had increased hazard of special needs education (HR = 2.7, 95% confidence interval (CI) = 1.8–4.1, p < 0.0001), lower grade point average at 9th grade by 1.7 grade points (95% CI = -2.5 to -1.0, p < 0.001), increased ADHD medicine use (HR = 4.4, 95% CI = 2.7–7.2, p < 0.001), increased sleep medicine use (HR = 2.7, 95% CI = 1.7–4.3, p < 0.001), and increased psychiatry visits (HR = 2.1, 95% CI = 1.1–4.0, p = 0.03).
In conclusion, children with CAE have increased psychiatric comorbidity and a considerable proportion of these children receive special needs education in primary/secondary school, albeit insufficient to normalize their considerably lower grade point average in the 9th grade.
Originalsprog | Engelsk |
---|---|
Tidsskrift | European Journal of Paediatric Neurology |
Vol/bind | 42 |
Sider (fra-til) | 75-81 |
Antal sider | 7 |
ISSN | 1090-3798 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The study received funding from Dagmar Marshalls Foundation , Helene og Viggo Bruuns Foundation , and Jascha Foundation .
Funding Information:
The National Patient Register (1977‒) contains information on patients admitted to Danish hospitals including the Danish Epilepsy Centre, Dianalund, which is the only private epilepsy center in Denmark. Data include the CPR number, date of admission and discharge diagnoses according to the International Classification of Diseases (ICD) version 8 (1977–1993) and ICD-10 (1994 until today) [14]. In Denmark, outpatient visits and hospital admissions are tax-funded and free of charge [15]. Outpatient visits to general practitioners and private practice are not in the register.The study received funding from Dagmar Marshalls Foundation, Helene og Viggo Bruuns Foundation, and Jascha Foundation.
Publisher Copyright:
© 2022 European Paediatric Neurology Society
ID: 367476981