A significant proportion of patients with depression do not respond to classic antidepressants addressing serotonergic or noradrenergic neurotransmission. Certain clinical features of depression seem to involve dopaminergic neurotransmission. Although medications with specific dopaminergic actions are used in the treatment of depression in other countries (e.g. the United States), these drugs are rarely mentioned in Danish treatment guidelines. This review aims at comprehending current dopaminergic treatment strategies and future directions in this field.