Predictors of mood and activity instability in participants with newly diagnosed bipolar disorder – Exploratory findings from a prospective cohort study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Predictors of mood and activity instability in participants with newly diagnosed bipolar disorder – Exploratory findings from a prospective cohort study. / von Hofacker, Anton Julius; Faurholt-Jepsen, Maria; Kjærstad, Hanne Lie; Coello, Klara; Vinberg, Maj; Stanislaus, Sharleny; Miskowiak, Kamilla; Kessing, Lars Vedel.
I: Journal of Affective Disorders Reports, Bind 15, 100708, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Predictors of mood and activity instability in participants with newly diagnosed bipolar disorder – Exploratory findings from a prospective cohort study
AU - von Hofacker, Anton Julius
AU - Faurholt-Jepsen, Maria
AU - Kjærstad, Hanne Lie
AU - Coello, Klara
AU - Vinberg, Maj
AU - Stanislaus, Sharleny
AU - Miskowiak, Kamilla
AU - Kessing, Lars Vedel
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2024
Y1 - 2024
N2 - Background: Daily variation in mood and activity between and within affective episodes in bipolar disorder has become a field of increasing interest. The present exploratory study aimed to identify predictors of mood and activity instability in participants with bipolar disorder (BD). Methods: A total of 258 participants with newly diagnosed BD type I and II were included as part of a longitudinal study (the Bipolar Illness Onset study (BIO)). The participants completed daily smartphone-based mood and activity ratings for a median [interquartile range] (IQR) of 109 days [40;240] and 106 days [40;243], respectively. Clinical evaluations and questionnaires were collected at the baseline visit. Backwards stepwise regression analysis was employed to identify predictors. Results: Predictors of increased mood instability included childhood trauma (e.g., B = 0.006, 95 % CI 0.001;0.011, p = 0.031), increasing number of depressive episodes, antipsychotic medication, functional impairment, and impaired sleep quality. Predictors of increased activity instability included longer Illness duration, lower age at onset, number of depressive episodes, functional impairment, and impaired sleep quality (e.g., B = 0.089, 95 %CI=0.033;0.145, p = 0.002). Limitations: Risk of type 1 error due to the large number of analyses. Conclusions: Increasing number of prior depressive episodes, functional impairment, and poor sleep quality were consistent predictors of subsequent increased mood and activity instability. Childhood trauma was a predictor of increased mood instability only, whereas age of onset was a predictor of increased activity instability only.
AB - Background: Daily variation in mood and activity between and within affective episodes in bipolar disorder has become a field of increasing interest. The present exploratory study aimed to identify predictors of mood and activity instability in participants with bipolar disorder (BD). Methods: A total of 258 participants with newly diagnosed BD type I and II were included as part of a longitudinal study (the Bipolar Illness Onset study (BIO)). The participants completed daily smartphone-based mood and activity ratings for a median [interquartile range] (IQR) of 109 days [40;240] and 106 days [40;243], respectively. Clinical evaluations and questionnaires were collected at the baseline visit. Backwards stepwise regression analysis was employed to identify predictors. Results: Predictors of increased mood instability included childhood trauma (e.g., B = 0.006, 95 % CI 0.001;0.011, p = 0.031), increasing number of depressive episodes, antipsychotic medication, functional impairment, and impaired sleep quality. Predictors of increased activity instability included longer Illness duration, lower age at onset, number of depressive episodes, functional impairment, and impaired sleep quality (e.g., B = 0.089, 95 %CI=0.033;0.145, p = 0.002). Limitations: Risk of type 1 error due to the large number of analyses. Conclusions: Increasing number of prior depressive episodes, functional impairment, and poor sleep quality were consistent predictors of subsequent increased mood and activity instability. Childhood trauma was a predictor of increased mood instability only, whereas age of onset was a predictor of increased activity instability only.
KW - Activity instability
KW - Bipolar disorder
KW - Mood instability
KW - Smartphone-based monitoring
U2 - 10.1016/j.jadr.2023.100708
DO - 10.1016/j.jadr.2023.100708
M3 - Journal article
AN - SCOPUS:85182915074
VL - 15
JO - Journal of Affective Disorders Reports
JF - Journal of Affective Disorders Reports
SN - 2666-9153
M1 - 100708
ER -
ID: 381724686