Struggling Can Also Show on the Inside: Current Knowledge of the Impact of Childhood Maltreatment on Biomarkers in Mood Disorderss
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Struggling Can Also Show on the Inside : Current Knowledge of the Impact of Childhood Maltreatment on Biomarkers in Mood Disorderss. / Vinberg, Maj; McIntyre, Roger S.; Giraldi, Annamaria; Coello, Klara.
I: Neuropsychiatric Disease and Treatment, Bind 20, 2024, s. 583-595.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Struggling Can Also Show on the Inside
T2 - Current Knowledge of the Impact of Childhood Maltreatment on Biomarkers in Mood Disorderss
AU - Vinberg, Maj
AU - McIntyre, Roger S.
AU - Giraldi, Annamaria
AU - Coello, Klara
N1 - Publisher Copyright: © 2024 Vinberg et al.
PY - 2024
Y1 - 2024
N2 - The link between childhood maltreatment and mood disorders is complex and involves multiple bio-psycho-social factors that affect multiple molecular pathways. The present narrative review aims to clarify the current understanding of the impact of childhood maltreatment on biomarkers in patients with mood disorders and their first-degree relatives. Neurotransmitters, such as serotonin, dopamine, norepinephrine, and hormones (eg the stress hormone cortisol), play a crucial role in regulating mood and emotion. Childhood maltreatment can alter and affect the levels and functioning of these neurotransmitters in the brain; further, childhood maltreatment can lead to structural and connectivity changes in the brain, hence contributing to the development of mood disorders and moderating illness presentation and modifying response to treatments. Childhood maltreatment information, therefore, appears mandatory in treatment planning and is a critical factor in therapeutic algorithms. Further research is needed to fully understand these pathways and develop new treatment modalities for individuals with mood disorders who have experienced childhood maltreatment and effective preventive interventions for individuals at risk of developing mood disorders.
AB - The link between childhood maltreatment and mood disorders is complex and involves multiple bio-psycho-social factors that affect multiple molecular pathways. The present narrative review aims to clarify the current understanding of the impact of childhood maltreatment on biomarkers in patients with mood disorders and their first-degree relatives. Neurotransmitters, such as serotonin, dopamine, norepinephrine, and hormones (eg the stress hormone cortisol), play a crucial role in regulating mood and emotion. Childhood maltreatment can alter and affect the levels and functioning of these neurotransmitters in the brain; further, childhood maltreatment can lead to structural and connectivity changes in the brain, hence contributing to the development of mood disorders and moderating illness presentation and modifying response to treatments. Childhood maltreatment information, therefore, appears mandatory in treatment planning and is a critical factor in therapeutic algorithms. Further research is needed to fully understand these pathways and develop new treatment modalities for individuals with mood disorders who have experienced childhood maltreatment and effective preventive interventions for individuals at risk of developing mood disorders.
KW - biomarkers
KW - biosignatures
KW - biotype
KW - childhood maltreatment
KW - mood disorders
U2 - 10.2147/NDT.S383322
DO - 10.2147/NDT.S383322
M3 - Review
AN - SCOPUS:85187669413
VL - 20
SP - 583
EP - 595
JO - Neuropsychiatric Disease and Treatment
JF - Neuropsychiatric Disease and Treatment
SN - 1176-6328
ER -
ID: 386413684