Aortic aneurysms cause major morbidities and mortalities. Operative intervention in ascending aneurysms and dissections is the treatment of choice although there is the risk of major complications because of technical difficulties, late diagnoses, affected hemodynamic and organ mal perfusion. Improved survival of heart transplant (HTx) recipients, acceptance of older donors with co morbidities and advances in HTx give rise to new pathological challenges in the cardiovascular field. Only a few articles have been reported about cardiac and aorta surgery in HTx recipients. Endovascular treatment for aortic pathology in zone 0 is an emerging treatment option. We report the first trans-apical endovascular ascending aorta repair (EVAR) in a 26-year-old HTx recipient, with the history of mediastinitis and lack of femoral access. She had an uneventful operative and post-operative EVAR course.